Carbon-11-labeled KF15372: A potential central nervous system adenosine A1 receptor ligand

Journal of Nuclear Medicine

Volumn 37, Issue 7, 1996, Pages 1203-1207

  Furuta, Riko ^b   Ishiwata, Kiichi ^a   Kiyosawa, Motohiro ^b   Ishii, Shin Ichi ^b   Saito, Noriko ^b   Shimada, Jun Ichi ^b   Endo, Kazutoyo ^b   Suzuki, Fumio ^b   Senda, Michio ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NONE

Author keywords

A1 receptor; adenosine; carbon 11 KF15372; PET; presynaptic neuron

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 DICYCLOPROPYLMETHYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; CARBON 11;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; ENUCLEATION; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RECEPTOR BINDING; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CARBON RADIOISOTOPES; EYE ENUCLEATION; MALE; MICE; MICE, INBRED STRAINS; NERVE DEGENERATION; PRESYNAPTIC TERMINALS; RADIOLIGAND ASSAY; RATS; RATS, INBRED STRAINS; RECEPTORS, PURINERGIC; TISSUE DISTRIBUTION; XANTHINES;

EID: 0029782663     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Olsson RA, Pearson JD. Cardiovascular purinoceptors. Physiol Rev 1990;70:761-854.
2. Collis MG, Hourani SMO. Adenosine receptor subtypes. Trends Pharmacol Sci 1993;14:360-366.
3. 1 antagonists; a new therapeutic approach to cognitive deficits and acute renal failure. Drug News Perspect 1992;5:587-591.
4. Goodman RR, Kuhar MJ, Hester L, Snyder SH. Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons. Science 1983;220: 967-969.
5. Silinski EM. On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve ending. J Physiol 1984;346:243-256.
6. Dunwiddie TV, Haas HL. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: evidence for a presynaptic site of action. J Physiol 1985;369:365-377.
7. Lupica CR, Proctor WR, Dunwiddie TV. Presynaptic inhibition of excitatory synaptic transmission by adenosine in rat hippocampus: analysis of unitary EPSP variance measured by whole-cell recording. J Neurosci 1992;12:3753-3764.
8. Prince DA, Stevens CF. Adenosine decreases neurotransmitter release at central synapses. Proc Natl Acad Sci USA 1992;89:8586-8590.
9. Scanziani M, Capogna M, Gahwiler BH, Thompson SM. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron 1992;9:919-927.
10. Scholz KP, Miller RJ. Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses. Neuron 1992;8:1139-1150.
11. 3H]adenosine. Eur J Pharmacol 1981;73:109-110.
12. 3H]cyclohexyladenosine. J Neurosci 1982;2:1230-1241.
13. 1 adenosine receptor regional density in the mouse brain: a quantitative autoradiographic study. Neuroscience 1993;56:711-716.
14. 1 receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neuroscience 1987;22:813-826.
15. 1 receptors in the human brain: a quantitative autoradiographic study. Neuroscience 1987;22:827-839.
16. Manzoni OJ, Manabe T, Nicoll RA. Release of adenosine by activation of NMDA receptors in the hippocampus. Science 1994;265:2098-2101.
17. Frost JJ. Imaging neuronal biochemistry by emission computed tomography: focus on neuroreceptors. Trends Pharmacol Sci 1986;7:490.
18. Mazière B, Mazière M. Where have we got to with neuroreceptor mapping of the human brain? Eur J Nucl Med 1990;16:817-835.
19. 1 antagonist. Appl Radiat Isot 1995;46:1009-1013.
20. 1 antagonist with renal protective and diuretic activities. J Med Chem 1991;34:466-469.
21. 1 antagonists. II. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. J Med Chem 1992;35:3066-3075.
22. 2 antagonists. J Med Chem 1992;35:2342-2345.
23. 3H]dopa in various regions of the brain. J Neurochem 1966;13:655-669.
24. Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW. 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci 1988;43:1671-1684.
25. Chalmers DT, McCulloch J. Selective alterations in glutamate receptor subtypes after unilateral orbital enucleation. Brain Res 1991;540:255-265.
26. Lund RD. Synaptic patterns of the superficial layers of the superior colliculus of rat. J Comp Neurol 1969;135:179-208.
27. Toga AW, Collins RC. Metabolic response of optic centers to visual stimuli in the albino rat: anatomical and physiological considerations. J Comp Neurol 1981;199: 443-464.
28. 1 receptor binding in the postischaemic rat brain. Neuroreport 1994;5:1453-1456.