Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol

In Vitro Cellular and Developmental Biology - Animal

Volumn 41, Issue 7, 2005, Pages 239-244

  Yamasaki, Masao ^a   Nishida, Eri ^a   Nou, Shinsuke ^b,c   Tachibana, Hirofumi ^a   Yamada, Koji ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c R and D Division   (Japan)

Author keywords

tocopherol; tocotrienol; Conjugated linoleic acid; Hepatoma; Oleic acid; Palmitoleic acid

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; CONJUGATED LINOLEIC ACID; ERAIDIC ACID; FATTY ACID DERIVATIVE; PALMITOLEIC ACID; POLYUNSATURATED FATTY ACID; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CIS TRANS ISOMERISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; ISOMERISM; LINOLEIC ACIDS, CONJUGATED; LIVER NEOPLASMS, EXPERIMENTAL; RATS; TOCOPHEROLS; TOCOTRIENOLS;

ANIMALIA;

EID: 27144453771     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1290/0402008.1     Document Type: Article

References (32)

1. Azzi, A.; Boscoboinik, D.; Marilley, D.; Ozer, N. K.; Stauble, B.; Tasinato, A. Vitamin E: a sensor and an information transducer of the cell oxidation state. Am. J. Clin. Nutr. 62:1337S-1346S; 1995.
2. Basu, S.; Smedman, A.; Vessby, B. Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett. 468:33-36; 2000.
3. Belury, M. A.; Nickel, K. P.; Bird, C. E.; Wu, Y. M. Dietary conjugated linoleic acid modulalion of phorbol ester skin tumor promotion. Nutr. Cancer 26:149-157; 1996.
4. Boscoboinik, D. O.; Chatelain, E.; Bartoli, G. M.; Stauble, B.; Azzi, A. Inhibition of protein kinase C activity and vascular smooth muscle cell growth by d-alpha-tocopherol. Biochim. Biophys. Acta 1224:418-426; 1994.
5. Choi, Y.; Kim, Y. C.; Han, Y. B.; Park, Y.; Pariza, M. W.; Ntambi, J. M. The trans-10,cis-12 isomer of conjugated linoleic acid downregulales stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130:1920-1924; 2000.
6. Chujo, H.; Yamasaki, M.; Nou, S.; Koyanagi, N.; Tachibana, H.; Yamada, K. Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells. Cancer Lett. 202:81-87; 2003.
7. Desbordes, C.; Lea, M. A. Effects of C18 fatty acids on DNA synthesis in hepatoma and breast cancer cells. Anticancer Res. 15:2017-2021; 1995.
8. Igarashi, M.; Miyazawa, T. The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. Biochim. Biophys. Acta 1530:162-171; 2001.
9. Ip, C.; Chin, S. F.; Scimeca, J. A.; Pariza, M. W. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res. 51:6118-6124; 1991.
10. Ip, C.; Singh, M.; Thompson, H. J.; Scimeca, J. A. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rats. Cancer Res. 54:1212-1215; 1994.
11. Kamp, F.; Zakim, D.; Zhang, F.; Noy, N.; Hamilton, J. A. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry 34:11928-11937; 1995.
12. Khanna, S.; Roy, S.; Ryu, H.; Bahadduri, P.; Swaan, P. W.; Ratan, R. R.; Sen, C. K. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem. 278:43508-43515; 2003.
13. Kleinfeld, A. M.; Storms, S.; Watts, M. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. Biochemistry 37:8011-8019; 1998.
14. Listenberger, L. L; Han, X.; Lewis, S. E.; Cases, S.; Farese, H. V., Jr.; Ory, D. S.; Schaffer, J. E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA 100:3077-3082; 2003.
15. Ntambi, J. M.; Miyazaki, M. Recent insights into stearoly-CoA desaturase. Curr. Opin. Lipidol. 14:255-261; 2003.
16. O'Shea, M.; Stanton, C.; Devery, R. C. Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. Anticancer Res. 19:1953-1959; 1999.
17. Palacios, A.; Piergiacomi, V.; Catala, A. Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria. Mol. Cell. Biochem. 250:107-113; 2003.
18. Park, Y.; Storkson, J. M.; Ntambi, J. M.; Cook, M. E.; Sih, C. J.; Pariza, M. W. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486:285-292; 2000.
19. Riserus, U.; Basu, S.; Jovinge, S.; Fredrikson, G. N.; Arnlov, J.; Vessby, B. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106:1925-1929; 2002.
20. Schonberg, S.; Krokan, H. E. The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. Anticancer Res. 15:1241-1246; 1995.
21. Sen, C. K.; Khanna, S.; Roy, S.; Packer, L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J. Biol. Chem. 275:13049-13055; 2000.
22. Shulz, T. D.; Chew, B. P.; Seaman, W. R.; Luedecke, L. O. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett. 63:125-133; 1992.
23. Suzuki, Y. J.; Tsuchiya, M.; Wassall, S. R.; Choo, Y. M.; Govil, G.; Kagan, V. E.; Packer, L. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32:10692-10699; 1993.
24. Tan, J.; Hallahan, D. E. Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res. 63:7663-7667; 2003.
25. Yamasaki, M.; Chujo, H.; Koga, Y.; Rikimaru, T.; Shimada, M.; Sugimachi, K.; Tachibana, H.; Yamada, K. Potent cytotoxic effect of trans-10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells. Cancer Lett. 188:171-180; 2002a.
26. Yamasaki, M.; Chujo, H.; Nou, S.; Tachibana, H.; Yamada, K. Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid. Cancer Lett. 196:187-196; 2003.
27. Yamasaki, M.; Ikeda, A.; Hirao, A.; et al. Effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84. Nutr. Cancer. 40:140-148; 2001.
28. Yamasaki, M.; Ikeda, A.; Hirao, A.; et al. Dose dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo. J. Nutr. Sci. Vitaminol. 48:505-511; 2002b.
29. Yamasaki, M.; Kishihara, K.; Mansho, K.; Ogino, Y.; Kasai, M.; Sugano, M.; Tachibana, H.; Yamada, K. Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. Biosci. Biotechnol. Biochem. 64:2159-2164; 2000.
30. Yoon, C. S.; Ha, T. Y.; Rho, J. H.; Sung, K. S.; Cho, I. J. Inhibitory effect of conjugated linoleic acid in vitro growth of human hepatoma. FASEB J. 11:A578; 1997.
31. Yu, L.; Adams, D.; Gabel, M. Conjugated linoleic acid isomers differ in their free radical scavenging properties. J. Agric. Food Chem. 50:4135-4140; 2001.
32. Zhong, M.; Lu, Z.; Foster, D. A. Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 21:1071-1078; 2002.