메뉴 건너뛰기




Volumn 172, Issue 10, 2004, Pages 5994-6002

Thymic Expression of a Gastritogenic Epitope Results in Positive Selection of Self-Reactive Pathogenic T Cells

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; HYBRID PROTEIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 2442597075     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.5994     Document Type: Article
Times cited : (10)

References (46)
  • 1
    • 0033025703 scopus 로고    scopus 로고
    • Thymic selection by a single MHC/peptide ligand: Autoreactive T cells are low-affinity cells
    • Lee, D. S., C. Ahn, B. Ernst, J. Sprent, and C. D. Surh. 1999. Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. Immunity 10:83.
    • (1999) Immunity , vol.10 , pp. 83
    • Lee, D.S.1    Ahn, C.2    Ernst, B.3    Sprent, J.4    Surh, C.D.5
  • 2
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
    • Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13:829.
    • (2000) Immunity , vol.13 , pp. 829
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 3
    • 0033673148 scopus 로고    scopus 로고
    • "Promiscuous" expression of tissue antigens in the thymus: A key to T-cell tolerance and autoimmunity?
    • Klein, L., and B. Kyewski. 2000. "Promiscuous" expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity? J. Mol. Med. 78:483.
    • (2000) J. Mol. Med. , vol.78 , pp. 483
    • Klein, L.1    Kyewski, B.2
  • 5
    • 0035546124 scopus 로고    scopus 로고
    • The T-cell repertoire available for recognition of self-antigens
    • Kreuwel, H. T., and L. A. Sherman. 2001. The T-cell repertoire available for recognition of self-antigens. Curr. Opin. Immunol. 13:639.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 639
    • Kreuwel, H.T.1    Sherman, L.A.2
  • 6
    • 0036721847 scopus 로고    scopus 로고
    • Endogenous H/K ATPase β-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant
    • Laurie, K. L., I. R. van Driel, T. D. Zwar, S. P. Barrett, and P. A. Gleeson. 2002. Endogenous H/K ATPase β-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant. J. Immunol. 169:2361.
    • (2002) J. Immunol. , vol.169 , pp. 2361
    • Laurie, K.L.1    Van Driel, I.R.2    Zwar, T.D.3    Barrett, S.P.4    Gleeson, P.A.5
  • 7
    • 0032526853 scopus 로고    scopus 로고
    • Endogenous myelin basic protein inactivates the high avidity T cell repertoire
    • Targoni, O. S., and P. V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187:2055.
    • (1998) J. Exp. Med. , vol.187 , pp. 2055
    • Targoni, O.S.1    Lehmann, P.V.2
  • 8
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101:455.
    • (2000) Cell , vol.101 , pp. 455
    • Sakaguchi, S.1
  • 9
    • 0035059416 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cells, tolerance and immunity
    • Heath, W. R., and F. R. Carbone. 2001. Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19:47.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 47
    • Heath, W.R.1    Carbone, F.R.2
  • 10
    • 0036740151 scopus 로고    scopus 로고
    • Tolerance induction to self antigens by peripheral dendritic cells
    • Lambolez, F., K. Jooss, F. Vasseur, and A. Sarukhan. 2002. Tolerance induction to self antigens by peripheral dendritic cells. Eur. J. Immunol. 32:2588.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2588
    • Lambolez, F.1    Jooss, K.2    Vasseur, F.3    Sarukhan, A.4
  • 11
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389
    • Shevach, E.M.1
  • 12
    • 0029659052 scopus 로고    scopus 로고
    • Organ-specific autoimmunity induced by lymphopenia
    • Gleeson, P. A., B. H. Toh, and I. R. van Driel. 1996. Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149:97.
    • (1996) Immunol. Rev. , vol.149 , pp. 97
    • Gleeson, P.A.1    Toh, B.H.2    Van Driel, I.R.3
  • 14
    • 0033739250 scopus 로고    scopus 로고
    • Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers
    • Radu, C. G., S. M. Anderton, M. Firan, D. C. Wraith, and E. S. Ward. 2000. Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers. Int. Immunol. 12:1553.
    • (2000) Int. Immunol. , vol.12 , pp. 1553
    • Radu, C.G.1    Anderton, S.M.2    Firan, M.3    Wraith, D.C.4    Ward, E.S.5
  • 18
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, I., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032
    • Derbinski, I.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 22
    • 0027220205 scopus 로고
    • An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus
    • Alderuccio, F., B. H. Toh, S. S. Tan, P. A. Gleeson, and I. R. van Driel. 1993. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. J. Exp. Med. 178:419.
    • (1993) J. Exp. Med. , vol.178 , pp. 419
    • Alderuccio, F.1    Toh, B.H.2    Tan, S.S.3    Gleeson, P.A.4    Van Driel, I.R.5
  • 24
    • 0035145221 scopus 로고    scopus 로고
    • Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K Atpase β-subunit
    • De Silva, H. D., F. Alderuccio, B. Hock Toh, I. R. van Driel, and P. A. Gleeson. 2001. Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K Atpase β-subunit. Autoimmunity 33:1.
    • (2001) Autoimmunity , vol.33 , pp. 1
    • De Silva, H.D.1    Alderuccio, F.2    Hock Toh, B.3    Van Driel, I.R.4    Gleeson, P.A.5
  • 25
  • 26
    • 0032728423 scopus 로고    scopus 로고
    • C-terminal extension of the MHC class II-associated invariant chain by an antigenic sequence triggers activation of naive T cells
    • Sponaas, A., C. Carstens, and N. Koch. 1999. C-terminal extension of the MHC class II-associated invariant chain by an antigenic sequence triggers activation of naive T cells. Gene Ther 6:1826.
    • (1999) Gene Ther , vol.6 , pp. 1826
    • Sponaas, A.1    Carstens, C.2    Koch, N.3
  • 27
    • 0019955568 scopus 로고
    • Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody
    • Koch, N., S. Koch, and G. J. Hammerling. 1982. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody. Nature 299:644.
    • (1982) Nature , vol.299 , pp. 644
    • Koch, N.1    Koch, S.2    Hammerling, G.J.3
  • 28
    • 0026537077 scopus 로고
    • The mouse gastric H,K-ATPase β subunit: Gene structure and co-ordinate expression with the a subunit during ontogeny
    • Morley, G. P., J. M. Callaghan, J. B. Rose, B. H. Toh, P. A. Gleeson, and I. R. van Driel. 1992. The mouse gastric H,K-ATPase β subunit: gene structure and co-ordinate expression with the a subunit during ontogeny. J. Biol. Chem. 267:1165.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1165
    • Morley, G.P.1    Callaghan, J.M.2    Rose, J.B.3    Toh, B.H.4    Gleeson, P.A.5    Van Driel, I.R.6
  • 29
    • 0027489002 scopus 로고
    • The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides
    • Freisewinkel, I. M., K. Schenck, and N. Koch. 1993. The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc. Natl. Acad. Sci. USA 90:9703.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9703
    • Freisewinkel, I.M.1    Schenck, K.2    Koch, N.3
  • 30
    • 0029084806 scopus 로고
    • Expression of a gastric autoantigen in pancreatic islets results in non-destructive insulitis after neonatal thymectomy
    • Barrett, S. P., I. R. van Driel, S. S. Tan, F. Alderuccio, B. H. Toh, and P. A. Gleeson. 1995. Expression of a gastric autoantigen in pancreatic islets results in non-destructive insulitis after neonatal thymectomy. Eur. J. Immunol. 25:2686.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2686
    • Barrett, S.P.1    Van Driel, I.R.2    Tan, S.S.3    Alderuccio, F.4    Toh, B.H.5    Gleeson, P.A.6
  • 31
    • 0037423287 scopus 로고    scopus 로고
    • GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network
    • Luke, M. R., L. Kjer-Nielsen, D. L. Brown, J. L. Stow, and P. A. Gleeson. 2003. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. J. Biol. Chem. 278:4216.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4216
    • Luke, M.R.1    Kjer-Nielsen, L.2    Brown, D.L.3    Stow, J.L.4    Gleeson, P.A.5
  • 32
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
    • (1992) J. Exp. Med. , vol.176 , pp. 1693
    • Inaba, K.1    Inaba, M.2    Romani, N.3    Aya, H.4    Deguchi, M.5    Ikehara, S.6    Muramatsu, S.7    Steinman, R.M.8
  • 34
    • 0031727316 scopus 로고    scopus 로고
    • Thymocyte selection: Not by TCR alone
    • Amsen, D., and A. M. Kruisbeek. 1998. Thymocyte selection: not by TCR alone. Immunol. Rev. 165:209.
    • (1998) Immunol. Rev. , vol.165 , pp. 209
    • Amsen, D.1    Kruisbeek, A.M.2
  • 35
    • 0030844377 scopus 로고    scopus 로고
    • Recent thymic emigrants are distinct from most medullary thymocytes
    • Gabor, M. J., D. I. Godfrey, and R. Scollay. 1997. Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 27:2010.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2010
    • Gabor, M.J.1    Godfrey, D.I.2    Scollay, R.3
  • 36
    • 18744435046 scopus 로고    scopus 로고
    • Restoration of T-cell homeostasis after T-cell depletion
    • Mackall, C. L., F. P. T. Hakim, and R. E. Gress. 1997. Restoration of T-cell homeostasis after T-cell depletion. Semin. Immunol. 9:339.
    • (1997) Semin. Immunol. , vol.9 , pp. 339
    • Mackall, C.L.1    Hakim, F.P.T.2    Gress, R.E.3
  • 37
    • 0035801476 scopus 로고    scopus 로고
    • T cell homeostasis: Thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors
    • Almeida, A. R., J. A. Borghans, and A. A. Freitas. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med 194:591.
    • (2001) J. Exp. Med , vol.194 , pp. 591
    • Almeida, A.R.1    Borghans, J.A.2    Freitas, A.A.3
  • 38
    • 0034284220 scopus 로고    scopus 로고
    • + T cells in the absence of self peptide:MHC complexes
    • + T cells in the absence of self peptide:MHC complexes. J. Immunol. 165:2458.
    • (2000) J. Immunol. , vol.165 , pp. 2458
    • Clarke, S.R.1    Rudensky, A.Y.2
  • 39
    • 0032811981 scopus 로고    scopus 로고
    • Autoimmune gastritis results in disruption of gastric epithelial cell development
    • Judd, L. M., P. A. Gleeson, B. H. Toh, and I. R. van Driel. 1999. Autoimmune gastritis results in disruption of gastric epithelial cell development. Am. J. Physiol. 277:G209.
    • (1999) Am. J. Physiol. , vol.277
    • Judd, L.M.1    Gleeson, P.A.2    Toh, B.H.3    Van Driel, I.R.4
  • 40
    • 0035477792 scopus 로고    scopus 로고
    • A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor
    • Sasada, T., Y. Ghendler, J. M. Neveu, W. S. Lane, and E. L. Reinherz. 2001. A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor. J. Exp. Med. 194:883.
    • (2001) J. Exp. Med. , vol.194 , pp. 883
    • Sasada, T.1    Ghendler, Y.2    Neveu, J.M.3    Lane, W.S.4    Reinherz, E.L.5
  • 45
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
    • (1998) J. Exp. Med. , vol.188 , pp. 287
    • Thornton, A.M.1    Shevach, E.M.2
  • 46
    • 0034933018 scopus 로고    scopus 로고
    • A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity
    • McHugh, R. S., E. M. Shevach, D. H. Margulies, and K. Natarajan. 2001. A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity. Eur. J. Immunol. 31:2094.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2094
    • McHugh, R.S.1    Shevach, E.M.2    Margulies, D.H.3    Natarajan, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.