Effects of hypoxia on the alveolar epithelium

Proceedings of the American Thoracic Society

Volumn 2, Issue 3, 2005, Pages 202-205

  Jain, Manu ^a   Sznajder, Jacob Iasha ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alveolar barrier; ENaC; Hypoxia; Na,K ATPase; Oxygen

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1; SODIUM CHANNEL; SURFACTANT; VASCULOTROPIN;

ADAPTATION; ALVEOLOCAPILLARY BARRIER; AMILORIDE SENSITIVE SODIUM CHANNEL; APOPTOSIS; CELL FUNCTION; CLEARANCE; CONFERENCE PAPER; CYTOSKELETON; EDEMA; ENZYME ACTIVITY; GENE ACTIVATION; GLYCOLYSIS; HUMAN; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG FUNCTION; LUNG GAS EXCHANGE; NONHUMAN; OXYGEN CONCENTRATION; PERMEABILITY BARRIER; PROTEIN SYNTHESIS; VASCULAR ENDOTHELIUM;

ANIMALS; ANOXIA; CELL HYPOXIA; EPITHELIUM; HUMANS; PULMONARY ALVEOLI; PULMONARY EDEMA;

EID: 27144435897     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200501-006AC     Document Type: Conference Paper

References (45)

1. Ouiddir A, Planes C, Fernandes I, VanHesse A, Clerici C. Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells. Am J Respir Cell Mol Biol 1999;21:710-718.
2. Suzuki S, Noda M, Sugita M, Ono S, Koike K, Fujimura S. Impairment of transalveolar fluid transport and lung Na(+)-K(+)-ATPase function by hypoxia in rats. J Appl Physiol 1999;87:962-968.
3. Suzuki S, Sugita M, Noda M, Tsubochi H, Fujimura S. Effects of intraalveolar oxygen concentration on alveolar fluid absorption and metabolism in isolated rat lungs. Respir Physiol 1999;115:325-332.
4. Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999;15:551-578.
5. Heerlein K, Schulze A, Hotz L, Bartsch P, Mairbaurl H. Hypoxia decreases cellular ATP-demand and inhibits mitochondrial respiration of A549 cells. Am J Respir Cell Mol Biol 2005;32:44-51.
6. Simon LM, Robin ED, Raffin T, Theodore J, Douglas WH. Bioenergetic pattern of isolated type II pneumocytes in air and during hypoxia. J Clin Invest 1978;61:1232-1239.
7. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 2002;283: L1133-L1142.
8. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-4613.
9. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292:464-468.
10. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-472.
11. Schroedl C, McClintock DS, Budinger GR, Chandel NS. Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 2002;283:L922-L931.
12. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT, Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 1998;95:11715-11720.
13. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 2001;98:296-302.
14. Chandel NS, Budinger GR, Choe SH, Schumacker PT. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem 1997;272;18808-18816.
15. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990;142:1250-1257.
16. Karhausen J, Ibla JC, Colgan SP. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand) 2003;49:77-87.
17. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med 2001;193:1027-1034.
18. Wodopia R, Ko HS, Billian J, Wiesner R, Bartsch P, Mairbaurl H. Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol 2000;279:L1110-L1119.
19. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol 2001; 25:554-561.
20. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 1996;270:L487-L503.
21. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 1994;367:463-467.
22. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med 1994;150:305-310.
23. Brochiero E, Dagenais A, Prive A, Berthiaume Y, Grygorczyk R. Evidence of a functional CFTR Cl(-) channel in adult alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004;287:L382-L392.
24. McCann JD, Welsh MJ. Basolateral K+ channels in airway epithelia: II. Role in Cl- secretion and evidence for two types of K+ channel. Am J Physiol 1990;258:L343-L348.
25. Crandall ED, Matthay MA. Alveolar epithelial transport. Basic science to clinical medicine. Am J Respir Crit Care Med 2001;163:1021-1029.
26. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol 2000;525:771-779.
27. Hackett PH. Mountain sickness: prevention, recognition and treatment. New York: American Alpine Club; 1980.
28. Maggiorini M, Melot C, Pierre S, Pfeiffer F, Greve I, Sartori C, Lepori M, Hauser M, Scherrer U, Naeije R. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 2001; 103:2078-2083.
29. Scherrer U, Sartori C, Lepori M, Allemann Y, Duplain H, Trueb L, Nicod P. High-altitude pulmonary edema: from exaggerated pulmonary hypertension to a defect in transepithelial sodium transport. Adv Exp Med Biol 1999;474:93-107.
30. Gowen CW Jr, Lawson EE, Gingras J, Boucher RC, Gatzy JT, Knowles MR. Electrical potential difference and ion transport across nasal epithelium of term neonates: correlation with mode of delivery, transient tachypnea of the newborn, and respiratory rate. J Pediatr 1988; 113:121-127.
31. Sartori C, Duplain H, Lepori M, Egli M, Maggiorini M, Nicod P, Scherrer U. High altitude impairs nasal transepithelial sodium transport in HAPE-prone subjects. Eur Respir J 2004;23:916-920.
32. Sartori C, Allemann Y, Duplain H, Lepori M, Egli M, Lipp E, Hutter D, Turini P, Hugli O, Cook S, et al. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 2002;346:1631-1636.
33. Bertorello AM, Ridge KM, Chibalin AV, Katz AI, Sznajder JI. Isoproterenol increases Na+-K+-ATPase activity by membrane insertion of alpha-subunits in lung alveolar cells. Am J Physiol 1999;276:L20-L27.
34. Mairbaurl H, Wodopia R, Eckes S, Schulz S, Bartsch P. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol 1997;273:L797-L806.
35. Planes C, Escoubet B, Blot-Chabaud M, Friedlander G, Farman N, Clerici C. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 1997;17:508-518.
36. Carpenter TC, Schomberg S, Nichols C, Stenmark KR, Weil JV. Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression. Am J Physiol Lung Cell Mol Physiol 2003;284:L77-L83.
37. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 2003;111:1057-1064.
38. Comellas AP, Pesce LM, Dada LA, Lecuona E, Zacharaias A, Budinger GS, Chandel N, Ciechanove A, Sznajder JI. Mitochodrial ROS mediate hypoxia-induced degradation on Na,K-ATPase in alveolar epithelial cells. Am J Respir Crit Care Med 2003;167:A663.
39. Qayyum I, Zubrow AB, Ashraf QM, Kubin J, Delivoria-Papadopoulos M, Mishra OP. Nitration as a mechanism of Na+,K+-ATPase modification during hypoxia in the cerebral cortex of the guinea pig fetus. Neurochem Res 2001;26:1163-1169.
40. Brown KR, England KM, Goss KL, Snyder JM, Acarregui MJ. VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 2001;281:L1001-L1010.
41. Clauss M, Weich H, Breier G, Knies U, Rockl W, Waltenberger J, Risau W. The vascular endothelial growth factor receptor Flt-1 mediates biological activities: implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 1996;271:17629-17634.
42. Ridge K, Ni N. Hypoxia regulates the expression of keratin 8 and 18 in alveolar epithelial cells. Am J Respir Crit Care Med 2004;169:A213.
43. Strassberg S, Godi I, Pandya D, Dudhbhai A, Parton L. Proinflammatory mediators amplify the apoptotic response of human lung cells during hypoxia. Am J Respir Crit Care Med 2004;169:A797.
44. Krick S, Appel J, Haenze J, Schmidt S, Weissman NGH, Grimminger F, Schermuly R, Seeger W, Rose F. Hypoxia syngergistically enhances Ang II induced apoptosis in alveolar epithelial cells by the activation of HIF-1 alpha and Ang II receptor type 1 [abstract]. Am J Respir Crit Care Med 2003;167:A798.
45. Haddad JJ, Land SC. The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-kappaB (RelA)-selective targeting. Biochem Biophys Res Commun 2000;271: 257-267.