Synthesis and caspase-3 inhibitory activity of 8-sulfonyl-1,3-dioxo-2,3- dihydro-1H-pyrrolo[3,4-c]quinolines

Farmaco

Volumn 60, Issue 10, 2005, Pages 804-809

  Kravchenko, Dmitri V ^a   Kysil, Volodymyr M ^b   Tkachenko, Sergey E ^a,b   Maliarchouk, Sergey ^a,b   Okun, Ilya M ^a,b   Ivachtchenko, Alexandre V ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

8 Sulfonyl 1,3 dioxo 4 methyl 2,3 dihydro 1H pyrrolo 3; 4 c quinolines; Caspase 3; Heterocycles; Inhibitor; Libraries

Indexed keywords

3 [[1,3 DIOXO 4 PHENYL 2 (1,3,5 TRIMETHYL 1H PYRAZOL 4 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 8 YL]SULFONYL]PROPANOIC ACID; 8 [(3 MORPHOLIN 4 YL 3 OXOPROPYL)SULFONYL] 4 PHENYL 2 (1,3,5 TRIMETHYL 1H PYRAZOL 4 YL) 1H PYRROLO[3,4 C]QUINOLINE 1,3(2H) DIONE; ACRYLIC ACID; CASPASE 3 INHIBITOR; ISATIN 5 SULFONATE; METHACRYLIC ACID; METHYL 3 [1,3 DIOXO 4 PHENYL 2 (1,3,5 TRIMETHYL 1H PYRAZOL 4 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 8 YL]SULFONYLPROPANOATE; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE; SUCCINIMIDE DERIVATIVE; SULFINIC ACID DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

CASPASE 3; CASPASES; ENZYME INHIBITORS; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26944501576     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.08.001     Document Type: Article

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