Regulation of sodium citrate on metabolic flux distribution of inosine fermentation process

Huagong Xuebao/Journal of Chemical Industry and Engineering (China)

Volumn 56, Issue 9, 2005, Pages 1731-1737

  Chen, Shuangxi ^a,b   Huang, Mingzhi ^a   Chu, Ju ^a   Zhuang, Yingping ^a   Zhang, Siliang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

Bacillus subtilis; Carbon overflow; Flux regulation; Inosine

Indexed keywords

CELL CULTURE; FERMENTATION; METABOLISM;

BACILLUS SUBTILIS; FLUX REGULATION; INOSINE'CARBON OVERFLOW;

MICROBIOLOGY;

EID: 26944497188     PISSN: 04381157     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Edwards J S, Palsson B O. How will bioinformatic-influence metabolic engineering. Biotechnol. Biaeng. 1998, 58 (2-3): 162-169
2. Goel A, Ferrance J, Jeong J, Ataai M M. Analysis of metabolic fluxes in batch and continuous cultures of Bacillu subtilis. Biotechnol. Bioeng., 1993, 42 (6): 686-696
3. Nielsen J. Metabolic engineering: techniques for analysis targets for genetic manipulation. Biotechnol. Bioeng. 1998, 58 (2-3): 125-132
4. Park S M, Sinskey A J, Stephanopoulos G. Metabolic and physiological studies of Corynebacterium glutamicun mutants. BiotechnoL Bioeng., 1997, 55 (6): 864-879
5. Liu Xinxing. Metabolic regulation and process optimization of inosine fermentation: [thesis]. Shanghai: East China University of Science and Technology, 2004
6. Chen Shuangxi, Cai Xianpeng, Wang Zhongshi, Chu Ju, Zhuang Yingping, Zhang Siliang. Study on optimization of guanosine fermentation. Microbiology, 2002, 29 (5): 65-69
7. + accumulation increases guanosine production by 70%. Chinese Journal of Biotechnology. 2003, 19 (2): 200-205
8. Sauer U, Cameron D C, Bailey J E. Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid. Biotechnol. Bioeng., 1998, 59 (2): 227-238
9. Goel A, Lee J, Domach M M, Ataai M M. Metabolic fluxes, pool and enzyme measurements suggest a tighter coupling of energetics and biosynthetic reactions associated with reduced pyruvate kinase flux. Biotechnol. Bioeng., 1999, 64 (2): 129-134
10. Majewski R A, Domach M M. Simple constrained-optimization view of acetate overflow in E. coli. Biotechnol. Bioeng., 1990, 35 (7): 732-738