Cardiology in the ageing heart: Models

Drug Discovery Today: Disease Models

Volumn 2, Issue 3, 2005, Pages 233-237

  Gray, Rosaire P ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL CULTURE; COMPUTER MODEL; CORONARY ARTERY DISEASE; ELDERLY CARE; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HIGH RISK PATIENT; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PATHOPHYSIOLOGY; RISK ASSESSMENT; RISK FACTOR; SENESCENCE;

EID: 26944476648     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2005.08.003     Document Type: Review

References (24)

1. E.G. Lakatta and S.J. Sollott Perspectives on mammalian cardiovascular aging: Humans to molecules Comp. Biochem. Physiol. Part A 132 2002 699-721
2. F.J. Sunderland et al. Mouse isolated perfused heart: Characteristics and cautions Clin. Exp. Pharmacol. Physiol. 30 2003 867-878
3. S.M. White et al. Cardiac physiology at the cellular level: Use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function Am. J. Physiol. Heart Circ. Physiol. 286 2004 H823-H829
4. R.D. Lipman et al. Pathologic characterisation of brown Norway, brown Norway × fisher 344 and Fisher 344 × brown Norway rats with relation to age J. Gerontol. A Biol. Sci. Med. Sci. 54 1996 B54-B59
5. T. Takeda Senescence-accelerated mouse (SAM): A biogerontological resource in ageing research Neurobiol. Aging 20 1999 105-110
6. Y. Nabeshima Klotho deficient mouse: An in vivo model for human ageing Drug Discov. Today: Dis. Models 1 2004 223-227
7. M. Kuro-o Disease model: Human aging Trends Mol. Med. 7 2001 179-181
8. K. Takeshita et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression Circulation 109 2004 1776-1782
9. B. Yang et al. Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships Am. J. Physiol. Heart Circ. Physiol. 46 1999 H1906-H1913
10. L. Monassier et al. Current mouse models for studying cardiac dysfunctions: Technical and imaging aspects Drug Discov. Today: Dis. Models 1 2004 235-241
11. F. Wiesmann et al. Developmental changes of cardiac function and mass with MRI in neonatal, juvenile and adult mice Am. J. Physiol. Heart Circ. Physiol. 278 2000 H652-H657
12. 2+-ATPase Circulation 101 2000 790-796
13. F. Huq et al. Gene transfer of Parvalbumin improves diastolic dysfunction in senescent myocytes Circulation 109 2004 2780-2785
14. C. Communal et al. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes Circulation 107 2003 1170-1175
15. P. Hunter et al. Integration from proteins to organs: The IUPS Physiome Project Mech. Ageing Dev. 126 2005 187-192
16. D. Noble Modelling the heart: From genes to cells to the whole organ Science 295 2002 1678-1682
17. E.G. Lakatta Arterial and cardiac ageing: Major shareholders in cardiovascular disease enterprises. III: Cellular and molecular clues to heart and arterial ageing Circulation 107 2003 490-497
18. I.R. Josephson et al. Alterations in properties of L-type Ca channels in ageing rat heart J. Mol. Cell. Cardiol. 24 2002 297-308
19. K. Wong et al. Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features Cardiovasc. Res. 37 1998 115-122
20. R.P. Xiao et al. Age-associated reductions in cardiac β1 and β2-adrenoreceptor responses without changes in inhibitory G proteins or receptor kinases J. Clin. Invest. 101 1998 1273-1282
21. 1-adrenergic and protein kinase-C dependent effects in senescent rats J. Gerontol. 59A 2004 1089-1098
22. R.P. Taylor and J.W. Starnes Age, cell signalling and cardioprotection Acta Physiol. Scand. 178 2003 107-116
23. M. Helenius et al. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-κB transcription factor in mouse cardiac muscle J. Mol. Cell. Cardiol. 28 1996 487-498
24. A. Leri et al. Telomerase activity in rat cardiac myocytes is age and gender dependent J. Mol. Cell. Cardiol. 32 2000 385-390