Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8

Neuropharmacology

Volumn 49, Issue 6, 2005, Pages 715-723

  Kniazeff, Julie ^a   Loland, Claus Juul ^a   Goldberg, Naomi ^b   Quick, Matthias ^b   Das, Shonit ^b   Sitte, Harald H ^a   Javitch, Jonathan A ^b   Gether, Ulrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Cl dependent transporters; Conformational changes; Cross linking; Dopamine transporter; Metal ion binding sites; Na+; Structure; Trytophan transporter

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CARRIER; AMINO ACID TRANSPORTER; CARRIER PROTEIN; CYSTEINE; DOPAMINE TRANSPORTER; MERCURY; METHIONINE; NEUROTRANSMITTER; PROTEIN SLC6; TRITIUM; TRYPTOPHAN; UNCLASSIFIED DRUG; ZINC ION;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM; BINDING SITE; CROSS LINKING; GENETIC CONSERVATION; MAMMAL; MOLECULAR EVOLUTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SYMBIOBACTERIUM THERMOPHILUM;

ANIMALS; CROSS-LINKING REAGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; EVOLUTION; EXTRACELLULAR SPACE; GENE EXPRESSION; MAMMALS; MEMBRANE TRANSPORT PROTEINS; MERCURY; MESYLATES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM; TRYPTOPHAN;

EID: 26944450526     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.07.003     Document Type: Article

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