Role of peripheral μ-opioid receptors in arthritis: Are they potential targets for therapy?

Arthritis and Rheumatism

Volumn 52, Issue 10, 2005, Pages 2955-2959

  Helyes, Zsuzsanna ^a,b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLIC AMP; DELTA OPIATE RECEPTOR; ENDOMORPHIN 1; FORMALDEHYDE; FREUND ADJUVANT; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE AGONIST; PROSTAGLANDIN;

ADJUVANT ARTHRITIS; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; CARTILAGE CELL; CHRONIC PAIN; DRUG TARGETING; EDITORIAL; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS; HUMANS; PAIN; RECEPTORS, OPIOID, MU;

EID: 26844470076     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21360     Document Type: Editorial

References (31)

1. International Association of the Study of Pain. Classification of chronic pain. Pain 1986;Suppl 3:S1-226.
2. Helyes Z, Pinter E, Nemeth J, Szolcsanyi J. Pharmacological targets for the inhibition of neurogenic inflammation. Curr Med Chem 2003;2:191-218.
3. Stein C, Yassouridis A. Peripheral morphine analgesia. Pain 1997;71:119-21.
4. Stein C, Machelska H, Binder W, Schafer M. Peripheral opioid analgesia. Curr Opin Pharmacol 2001;1:62-5.
5. Ferreira SH. Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists. Br J Clin Pharmacol 1980;10:237S-45S.
6. Stein C, Hassan AH, Przewlocki R, Gramsch C, Peter K, Herz A. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc Natl Acad Sci U S A 1990;87:5935-9.
7. Bartho L, Szolcsanyi J. Opiate agonists inhibit neurogenic plasma extravasation in the rat. Eur J Pharmacol 1981;73:101-4.
8. Rashid H, Inoue M, Toda K, Ueda H. Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain. J Pharmacol Exp Ther 2004;309:380-7.
9. Li Z, Proud D, Zhang C, Wiehler S, McDougall JJ. Chronic arthritis down-regulates peripheral μ-opioid receptor expression with concomitant loss of endomorphin 1 antinociception. Arthritis Rheum 2005;52:3210-9.
10. Nagakura Y, Okada M, Kohara A, Kiso K, Toya T, Iwai A, et al. Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics. J Pharmacol Exp Ther 2003;306:490-7.
11. Cain CK, Francis JM, Plone MA, Emerich DF, Lindner MD. Pain-related disability and effects of chronic morphine in the adjuvant-induced arthritis model of chronic pain. Physiol Behav 1997;62:199-205.
12. Helyes Z, Szabo A, Nemeth J, Jakab B, Pinter E, Banvolgyi A, et al. Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis Rheum 2004;50:1677-85.
13. Ballet S, Conrath M, Fischer J, Kaneko T, Hamon T, Cesselin F. Expression and G-protein coupling of μ-opioid receptors in the spinal cord and dorsal root ganglia of polyarthritic rats. Neuropeptides 2003;37:211-9.
14. Yu YC, Koo ST, Kim CH, Lyu Y, Grady JJ, Chung JM. Two variables that can be used as pain indices in experimental animal models of arthritis. J Neurosci Methods 2002;115:107-13.
15. Machelska H, Mousa SA, Brack A, Schopohl JK, Rittner HL, Schafer M, et al. Opioid control of inflammatory pain regulated by intracellular adhesion molecule-1. J Neurosci 2002;22:5588-96.
16. Przewlocki R, Przewlocka B. Opioids in chronic pain. Eur J Pharmacol 2001;429:79-91.
17. Zhang Q, Schafer M, Elde R, Stein C. Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia. Neuroscience 1998;85:281-91.
18. Pol O, Puig MM. Expression of opioid receptors during peripheral inflammation. Curr Top Med Chem 2004;4:51-61.
19. Zollner C, Shaqura MA, Bopaiah CP, Stein C, Schafer M. Painful inflammation-induced increase of μ-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 2003;64:202-10.
20. Mousa SA, Machelska H, Schafer M, Stein C. Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain. J Neuroimmunol 2002;126:5-15.
21. Puehler W, Zollner C, Brack A, Shaqura MA, Krause H, Schafer M, et al. Rapid upregulation of μ opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction. Neuroscience 2004;129:473-9.
22. Shaqura MA, Zollner C, Mousa SA, Stein C, Schafer M. Characterization of μ opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain. J Pharmacol Exp Ther 2004;308:712-8.
23. Elvenes J, Andjelkov N, Figenschau Y, Seternes T, Bjorkoy G, Johansen O. Expression of functional μ-opiod receptors in human osteoarthritic cartilage and chondrocytes. Biochem Biophys Res Commun 2003;311:202-7.
24. McDougall JJ, Barin AK, McDougall CM. Loss of vasomotor responsiveness to the μ-opioid receptor ligand endomorphin-1 in adjuvant monoarthritic rat knee joints. Am J Physiol Regul Integr Comp Physiol 2004;286:R634-41.
25. Pak Y, Kouvelas A, Scheideler MA, Rasmussen J, O'Dowd BF, George SR. Agonist-induced functional desensitization of the μ-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein. Mol Pharmacol 1996;50: 1214-22.
26. Ji RR, Zhang Q, Law PY, Low HH, Elde R, Hokfelt T. Expression of μ-, δ- and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. Neuroscience 1995;15:8156-66.
27. Zadina JE, Hackler L, Lin-Jun G, Kastin AJ. A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997;386:499-502.
28. McDougall JJ, Baker CL, Hermann PM. Attenuation of knee joint inflammation by peripherally administered endomorphin-1. J Mol Neurosci 2004;22:125-37.
29. Hammond DL. Persistent inflammatory nociception and hyperalgesia: implications for opioid actions in the brainstem and spinal cord. In: Brune K, Handwerker HO, editors. Hyperalgesia: molecular mechanisms and clinical implications, progress in pain research and management. Vol. 30. Seattle: IASP Press; 2004. p. 291-309.
30. Wrench IJ, Taylor P, Hobbs GJ. Lack of efficacy of intra-articular opioids for analgesia after day-case arthroscopy. Anaesthesia 1996;51:920-2.
31. Rosseland LA. No evidence for analgesic effect of intraarticular morphine after knee arthroscopy: a qualitative systematic review. Reg Anesth Pain Med 2005;30:83-98.