A comparison of cyclohexanone and tetrahydro-4H-thiopyran-4-one 1,1-dioxide as pharmacophores for the design of peptide-based inhibitors of the serine protease plasmin

Journal of Organic Chemistry

Volumn 70, Issue 21, 2005, Pages 8309-8321

  Xue, Fengtian ^a   Seto, Christopher T ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; SYNTHESIS (CHEMICAL); TUMORS;

ANGIOGENESIS; METASTASIS; PLASMINOGEN SYSTEMS; PROTEOLYTIC CASCADES;

ORGANIC COMPOUNDS;

CYCLOHEXANONE; PLASMIN INHIBITOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SULFONE; TETRAHYDRO 4H THIOPYRAN 4 ONE 1,1 DIOXIDE; THIOPYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; CANCER INHIBITION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVATION; IC 50; METASTASIS; PHARMACOPHORE; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANTIFIBRINOLYTIC AGENTS; CYCLIC S-OXIDES; CYCLOHEXANONES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MOLECULAR STRUCTURE; PEPTIDES; PLASMIN;

EID: 26844449317     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0508954     Document Type: Article

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