Morphine modulates lymph node-derived T lymphocyte function: Role of caspase-3, -8, and nitric oxide

Journal of Leukocyte Biology

Volumn 70, Issue 4, 2001, Pages 527-536

  Wang, J ^a   Charboneau, R ^a   Balasubramanian, S ^a   Barke, R A ^a   Loh, H H ^a   Roy, S ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

opioid receptor knock out; Apoptosis; Induced nitric oxide synthase; Wild type

Indexed keywords

CASPASE 3; CASPASE 8; GAMMA INTERFERON; INTERLEUKIN 2; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE DEFICIENCY; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOTOXICITY; INTERFERON PRODUCTION; LYMPH NODE CELL; MORPHINE ADDICTION; MOUSE; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MORPHINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, OPIOID, MU; RNA, MESSENGER; T-LYMPHOCYTES;

ANIMALIA;

EID: 0034793410     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Immunologic dysfunction in heroin addicts
2. Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes
3. Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: In vivo evidence for opiate receptor sites on T lymphocytes
4. Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model
5. Morphine and methadone impact on human phagocytic physiology
6. Lethality of morphine in mice infected with toxoplasma gondii
7. Morphine-induced immunomodulation is not related to serum morphine concentrations
8. Morphine-induced alterations of immune status: Dose dependency, compartment specificity and antagonism by naltrexone
9. Effects of certain abused drugs on hemolysin forming cells
10. Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids
11. Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes
12. Morphine modulates NF kappa B activation in macrophages
13. Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells
14. Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages
15. Morphine promotes apoptosis in Jurkat cells
16. Morphine-induced macrophage apoptosis: The role of transforming growth factor-beta
17. Immunoregulatory effects of morphine on human lymphocytes
18. Involvement of brain opiate receptors in the immune-suppressive effect of morphine
19. Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats
20. Immunomodulation mediated by microinjection of morphine into the periaqueductal gray matter of the mesencephalon
21. Immunosuppression by morphine is mediated by central pathways
22. Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages
23. Morphine binding sites on human T lymphocytes
24. Mu opioid receptor gene expression in immune cell
25. Human granulocytes contain an opiate alkaloid-selective receptor mediating inhibition of cytokine-induced activation and chemotaxis
26. Morphine up-regulates mu opioid receptors of human and monkey lymphocytes
27. Mu-opioid receptor-knockout mice: Role of μ-opioid receptor in morphine mediated immune functions
28. Characterization of [3H]morphine binding to interleukin-1-activated thymocytes
29. Morphine increases susceptibility to oral salmonella typhimurium infection
30. Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice
31. Morphine depresses macrophage numbers and function in mouse spleens
32. The effects of interaction between morphine and interleukin-1 on the immune response
33. Opiate binding sites on cells of the immune system
34. Opiate receptors on lymphocytes and platelets in man
35. Evidence for opioid receptors on cells involved in host defense and the immune system
36. Mu-opioid receptor-knockout mice: The role of mu-opioid receptor in gastrointestinal transit
37. Presence of nociceptin (orphanin FQ) receptors in rat retina: Comparison with receptors in striatum
38. Delta2 opioid receptor subtype on human vascular endothelium uncouples morphine stimulated nitric oxide release
39. Properties of mu 3 opiate alkaloid receptors in macrophages, astrocytes, and HL-60 human promyelocytic leukemia cells
40. The presence of the mu3 opiate receptor in invertebrate neural tissues
41. The morphine-binding site on human activated T-cells is not related to the mu-opioid receptor
42. Fas-mediated cell death promoted by opioids
43. Functional characterization of Jurkat T cells rescued from CD95/Fas-induced apoptosis through the inhibition of caspases
44. Caspase activation is required for T cell proliferation
45. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
46. Caspases: Multifunctional proteases
47. A caspase-activited DNase that degrades DNA during apoptosis, and its inhibitor ICAD
48. Conversion of Bcl-2 to a Bax-like death effector by caspases
49. Caspase-2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis
50. Mechanisms whereby macrophage-derived nitric oxide is involved in morphine-induced suppression of splenic lymphocyte proliferation
51. Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo
52. Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes
53. Morphine enhances macrophage apoptosis
54. Dopamine and morphine stimulate nitric oxide release in human endometrial glandular epithelial cells
55. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu (3) opiate receptor-dependent mechanism
56. Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism
57. Rebound from nitric oxide inhibition triggers enhanced monocyte activation and chemotaxis
58. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
59. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/ATAT5 signaling
60. Nitric oxide suppresses human T lymphocyte proliferation through IFN-γ-dependent and IFN-γ-independent induction of apoptosis