Ciglitazone inhibits the antigen-induced leukotrienes production independently of PPARγ in RBL-2H3 mast cells

European Journal of Pharmacology

Volumn 521, Issue 1-3, 2005, Pages 21-28

  Okuyama, Kaori ^a   Yamashita, Masamichi ^a   Kitabatake, Yuki ^a   Kawamura, Shunsuke ^a   Takayanagi, Motoaki ^a   Ohno, Isao ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ciglitazone; Cycteinyl leukotrienes; Independence; Mast cell; Peroxisome prolifelator activated receptor

Indexed keywords

ACYL COENZYME A; BINDING PROTEIN; CIGLITAZONE; CYSTEINE; IMMUNOGLOBULIN E RECEPTOR; LEUKOTRIENE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D2; TROGLITAZONE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GENE EXPRESSION REGULATION; INHIBITION KINETICS; MAST CELL; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENETICS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ACYL COENZYME A; ANIMALS; ANTIGENS; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CYSTEINE; EICOSANOIDS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LEUKOTRIENES; MAST CELLS; PPAR GAMMA; RECEPTORS, IGE; RNA, MESSENGER; THIAZOLIDINEDIONES;

EID: 26444497518     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.08.010     Document Type: Article

References (38)

1. D.G. Alleva, E.B. Johnson, F.M. Lio, S.A. Boehme, P.J. Conlon, and P.D. Crowe Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferator-activated receptor-γ: counter-regulatory activity by IFN-γ J. Leukoc. Biol. 71 2002 677 685
2. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am. J. Respir. Crit. Care Med. 161 2000 1720 1745
3. 2 in activated murine macrophages Mol. Cell. Biol. 20 2000 1692 1698
4. A. Chawla, Y. Barak, L. Nagy, D. Liao, P. Tontonoz, and R. Evans PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation Nat. Med. 7 2001 48 52
5. F. Chen, and L.E. Harrison Ciglitazone induces early cellular proliferation and NF-κB transcriptional activity in colon cancer cells through p65 phosphorylation Int. J. Biochem. Cell Biol. 37 2005 645 654
6. G. Chinetti, J.C. Fruchart, and B. Staels Peroxisome proliferator- activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation Inflamm. Res. 49 2000 497 505
7. M. Coffey, and M. Peters-Golden Extending the understanding of leukotrienes in asthma Curr. Opin. Allergy Clin. Immunol. 3 2003 57 63
8. P.R. Colville-Nash, S.S. Qureshi, D. Wills, and D.A. Willoughby Inhibition of inducible nitric oxide synthase by peroxisome proliferator- activated receptor agonists: correlation with induction of heme oxygenase 1 J. Immunol. 161 1998 978 984
9. B.L. Diaz, H. Fujishima, Y. Kanaoka, Y. Urade, and J.P. Arm Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids J. Immunol. 168 2002 1397 1404
10. 2 on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells Biochem. Pharmacol. 67 2004 1259 1267
11. Y. Fujimura, H. Tachibana, and K. Yamada Peroxisome proliferator- activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells Biochem. Biophys. Res. Commun. 297 2002 193 201
12. S.G. Harris, and R.P. Phipps The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPARγ agonists induce apoptosis Eur. J. Immunol. 31 2001 1098 1105
13. G. He, P. Thuillier, and S.M. Fischer Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARγ in normal mouse skin keratinocytes J. Invest. Dermatol. 123 2004 1110 1119
14. T. Helledie, L. Grontved, S.S. Jensen, P. Kiilerich, L. Rietveld, T. Albreksen, M.S. Boysen, J. Nohr, L.K. Larsen, J. Fleckner, H.G. Stunnenberg, K. Kristiansen, and S. Mandrup The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor γ through an intronic response element functionally conserved between humans and rodents J. Biol. Chem. 277 2002 26821 26830
15. K. Honda, P. Marquillies, M. Capron, and D. Dombrowicz Peroxisome proliferator-activated receptor γ is expressed in airways and inhibits features of airway remodeling in a mouse asthma model J. Allergy Clin. Immunol. 113 2004 882 888
16. J.T. Huang, J.S. Welch, M. Ricote, C.J. Binder, T.M. Willson, C. Kelly, J.L. Witztum, C.D. Funk, D. Conrad, and C.K. Glass Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase Nature 400 1999 378 382
17. C. Jiang, A.T. Ting, and B. Seed PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines Nature 391 1998 82 86
18. 2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats J. Clin. Invest. 106 2000 189 197
19. Y. Kitabatake, S. Kawamura, M. Yamashita, K. Okuyama, M. Takayanagi, and I. Ohno The expression of mRNA for calcitonin gene-related peptide receptors in a mucosal type mast cell line, RBL-2H3 Biol. Pharm. Bull. 27 2004 896 898
20. B.B. Kragelund, J. Knudsen, and F.M. Poulsen Acyl-coenzyme A binding protein (ACBP) Biochim. Biophys. Acta 1441 1999 150 161
21. 4 synthase Prostaglandins Leukot. Essent. Fat. Acids 69 2003 111 116
22. B.E.A. Lams, and T.H. Lee The role of cysteinyl leukotrienes in asthma: from the molecule to the bedside Allergol. Intern. 45 1996 163 169
23. L.M. Leesnitzer, D.J. Parks, R.K. Bledoe, J.E. Cobb, J.L. Collins, T.G. Consler, R.G. Davis, E.A. Hull-Ryde, J.M. Lenhard, L. Patel, K.D. Plunket, J.L. Shenk, J.B. Stimmel, C. Therapontos, T.M. Willson, and S.G. Blanchard Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662 Biochemistry 41 2002 6640 6650
24. K. Maeda, H. Taniguchi, I. Ohno, H. Ohtsu, K. Yamauchi, E. Sakurai, Y. Tanno, J.H. Butterfield, T. Watanabe, and K. Shirato Induction of l-histidine decarboxylase in a human mast cell line, HMC-1 Exp. Hematol. 26 1998 325 331
25. G. Marone, M. Triggiani, and A. de Paulis Mast cells and basophils: friends as well as foes in bronchial asthma? Trends Immunol. 26 2005 25 31
26. I.G. Reischl, W.R. Coward, and M.K. Church Molecular consequences of human mast cell activation following immunoglobulin E-high-affinity immunoglobulin E receptor (IgE-FcepsilonRI) interaction Biochem. Pharmacol. 58 1999 1841 1850
27. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature 391 1998 79 82
28. A. Shibuya, K. Wada, A. Nakajima, M. Saeki, K. Katayama, T. Mayumi, T. Kadowaki, H. Niwa, and Y. Kamisaki Nitration of PPARγ inhibits ligand-dependent translocation into the nucleus in a macrphage-like cell line, RAW 264 FEBS Lett. 525 2002 43 47
29. 2 inhibits multiple steps in the NF-κB signaling pathway Proc. Natl. Acad. U. S. A. 97 2000 4844 4849
30. K. Subbaramaiah, D.T. Lin, J.C. Hart, and A.J. Dannenberg Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300 J. Biol. Chem. 276 2001 12440 12448
31. H. Sugiyama, T. Nonaka, T. Kishimoto, K. Komoriya, K. Tsuji, and T. Nakahata Peroxisome proliferator-activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation Eur. J. Immunol. 30 2000 3363 3370
32. H. Sugiyama, T. Nonaka, T. Kishimoto, K. Komoriya, K. Tsuji, and T. Nakahata Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells FEBS Lett. 467 2000 259 262
33. A. Trifilieff, A. Bench, M. Hanley, D. Bayley, E. Campbell, and P. Whittaker PPAR-α and-γ but not-δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-κB-independent effect Br. J. Pharmacol. 139 2003 163 171
34. S. Ueki, T. Adachi, J. Bourdeaux, H. Oyamada, Y. Yamada, K. Hamada, A. Kanda, H. Kayaba, and J. Chihara Expression of PPARγ in eosinophils and its functional role in survival and chemotaxis Immunol. Lett. 86 2003 183 189
35. O. Werz 5-lipoxygenase: cellular biology and molecular pharmacology Curr. Drug Targets Inflamm. Allergy 1 2002 23 44
36. G. Woerly, K. Honda, M. Loyens, J.P. Papin, J. Auwerx, B. Staels, M. Capron, and D. Dombrowicz Peroxisome proliferator-activated receptors α and γ down-regulate allergic inflammation and eosinophil activation J. Exp. Med. 198 2003 411 421
37. M. Yamashita, M. Kushihara, N. Hirasawa, W. Takasaki, H. Takahagi, M. Takayanagi, and K. Ohuchi Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells Br. J. Pharmacol. 129 2000 367 373
38. 4 metabolism J. Lipid Mediators Cell Signal. 12 1995 321 332