Can an allograft become harmonious with its recipient by analogous mechanisms to the long-term survival of a parasite in its host? Transplantation is similar to parasitism and chronic parasite infection can prolong allograft survival

Medical Hypotheses

Volumn 65, Issue 6, 2005, Pages 1047-1050

  Zhigui, Zeng ^a   Ming, Changsheng ^a   Zhongguang, Zhen ^a   Renhu, Sun ^a   Wenwei, Chen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATIN; CYTOKINE; ICOSANOID;

ALLOGRAFT; ANTIGEN PRESENTATION; ARTICLE; BYSTANDER EFFECT; CLINICAL RESEARCH; CYTOKINE PRODUCTION; DENDRITIC CELL; GRAFT SURVIVAL; HOST PARASITE INTERACTION; ICOSANOID METABOLISM; IMMUNE RESPONSE; LONG TERM EXPOSURE; NONHUMAN; ORGAN TRANSPLANTATION; PARASITE TRANSMISSION; PARASITE VIRULENCE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

CHRONIC DISEASE; GRAFT REJECTION; GRAFT SURVIVAL; HOST-PARASITE RELATIONS; INFECTION; MODELS, IMMUNOLOGICAL; PARASITIC DISEASES; SURVIVAL RATE; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

ANIMALIA;

EID: 26444475366     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.06.027     Document Type: Article

References (33)

1. C.G. Groth, and J.R. Chapman The global alliance for transplantation Transplantation 79 9 2005 994 996
2. N.L. Tilney, W.D. Whitley, J.R. Diamond, J.W. Kupiec-Weglinski, and D.H. Adams Chronic rejection - an undefined conundrum Transplantation 52 1991 389 398
3. B. Dussol, M. Reynaud-Gaubert, Y. Saingra, L. Daniel, and Y. Berland Acute tubular necrosis induced by high level of cyclosporine a in a lung transplant Transplantation 70 8 2000 1234 1236
4. M. Woo, D. Przepiorka, and C. Ippoliti Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation Bone Marrow Transplant 20 12 1997 1095 1098
5. R. Muller In worms and human disease 2002 CABI Publishing Wallingford (UK) p. 1-161
6. R.M. Maizels, and M. Yazdanbakhsh Immune regulation by helminth parasites: cellular and molecular mechanisms Nat Rev Immunol 3 9 2003 733 744
7. D. Jankovic, M.C. Kullberg, P. Caspar, and A. Sher Parasite-induced Th2 polarization is associated with downregulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling J Immunol 173 4 2004 2419 2427
8. D.L. Ledingham, V.C. McAlister, H.N. Ehigiator, C. Giacomantonio, M. Theal, and T.D.G. Lee Prolongation of rat kidney allograft survival by nematodes Transplantation 61 2 1996 184 188
9. R. Liwski, J. Zhou, V. McAlister, and Timothy D.G. Lee Prolongation of allograft survival by nippostrongy lusbrasiliensis is associated with decreased allospecific cytotoxic T lymphocyte activity and development of T cytotoxic cell type 2 cells Transplantation 69 9 2000 1912 1922
10. A. Arakelov, and F.G. Lakkis The alloimmune response and effector mechanisms of allograft rejection Semin Nephrol 20 2000 95 102
11. A. Le Moine, M. Goldman, and D. Abramowicz Multiple pathways to allograft rejection Transplantation 73 9 2002 1373 1381
12. S. Hadidi, and R.M. Gorczynski MD-1 expression regulates direct and indirect allorecognition Tissue Antigens 63 2 2004 132 141
13. M.H. Sayegh, and L.A. Turka The role of T-cell co-stimulatory activation pathways in transplant rejection New Eng J Med 338 25 1998 1813 1821
14. L.J. McHeyzer-Williams, and M.G. McHeyzer-Williams Antigen-specific memory B cell development Annu Rev Immunol 23 2005 487 513
15. M. Sadeghi, V. Daniel, R. Weimer, M. Wiesel, O. Hergesell, and G. Opelz Pre-transplant Th1 and post-transplant Th2 cytokine patterns are associated with early acute rejection in renal transplant recipients Clin Transplant 17 2 2003 151 157
16. S.S. Metkar, B. Wang, and M. Aguilar-Santelises Cytotoxic cell granulemediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation Immunity 16 2002 417 428
17. J.H. Russell, and T.J. Ley Lymphocyte-mediated cytotoxicity Annu Rev Immunol 20 2002 323 370
18. J. Alexander, and K. Bryson T helper (h)1/Th2 and Leishmania: paradox rather than paradigm Immunol Lett 99 1 2005 17 23
19. B. Manoury, W.F. Gregory, R.M. Maizels, and C. Watts Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing Curr Biol 11 2001 447 451
20. A. Schönemeyer, R. Lucius, and B. Sonnenburg Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus J Immunol 167 2001 3207 3215
21. T. Dainichi, Y. Maekawa, and K. Ishii Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response Infect Immun 69 2001 7380 7386
22. P. Pierre, and I. Mellman Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells Cell 93 1998 1135 1145
23. S. Hartmann, B. Kyewski, B. Sonnenburg, and R. Lucius A filarial cysteine protease inhibitor downregulates T cell proliferation and enhances interleukin-10 production Eur J Immunol 27 1997 2253 2260
24. H. von Boehmer Mechanisms of suppression by suppressor T cells Nat Immunol 6 2005 338 344
25. M. Hesse, Ciriaco A. Picccirillo, and Y. Belkaid The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate factor and regulatory T cells J Immunol 172 2004 3157 3166
26. Y. Belkaid, and Barry T. Rouse Natural regulatory T cells in infectious disease Nat Immunol 6 2005 353 360
27. A. Doetze, J. Satoguina, and G. Burchard Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by TH3/TR1-type cytokines IL-10 and transforming growth factor-β but not by a TH1 to TH2 shift Int Immunol 12 2000 623 630
28. J. Satoguina, M. Mempel, and J. Larbi Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis) Microbes Infect 4 2002 1291 1300
29. Gerard L. Bannenberg, J. Aliberti, S. Hong, A. Sher, and C. Serhan Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis JEM 199 4 2004 515 523
30. Charles N. Serhan, M. Hamberg, and B. Samuelsson Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc Natl Acad Sci USA 81 17 1984 5335 5339
31. T. Lawrence, D.A. Willoughby, and D.W. Gilroy Anti-inflammatory lipid mediators and insights into the resolution of inflammation Nat Rev Immunol 2 10 2002 787 795
32. J. Aliberti, S. Hieny, R. e Sousa, C.N. Serhan, and A. Sher Lipoxin-mediated inhibaition of Il-12 production by DCs a mechanism for regulation of microbial immunity Nat Immunol 3 1 2002 76 82
33. Zhen Z-HG, Ming C-HS-H, Zeng Z-HG, et al. Chin J Organ Transplant [in press].