Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: Analysis and mechanistic implications

Biochemistry

Volumn 43, Issue 22, 2004, Pages 7187-7196

  Poelarends, Gerrit J ^a   Serrano, Hector ^a   Johnson Jr , William H ^a   Whitman, Christian P ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; BACTERIA; CHEMICAL BONDS; CRYSTALLOGRAPHY; DEHALOGENATION; HYDROLYSIS; MASS SPECTROMETRY; OXYGEN; SUBSTITUTION REACTIONS;

NUCLEOPHILES; STEREOSPECIFIC ALKYLATION;

ENZYMES;

3 CHLOROACRYLIC ACID DEHALOGENASE; ACRYLIC ACID DERIVATIVE; ENZYME; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEHALOGENATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KINETICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY;

ACRYLATES; ALKYLATION; ARGININE; BINDING SITES; CARBOXYLIC ACIDS; CATALYSIS; ETHYLENE OXIDE; HYDROLASES; KINETICS; MALONATES; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; MUTATION; PSEUDOMONAS; STEREOISOMERISM;

BACTERIA (MICROORGANISMS);

EID: 2642526986     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049823h     Document Type: Article

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