Origin of PACAP-immunoreactive nerve fibers innervating the subarachnoidal blood vessels of the rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 6, 2004, Pages 628-635

  Martin, Florian ^a   Baeres, Moesgaard ^a   Moller, Morten ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fluorogold; Otic ganglion; Retrograde tracing; Sphenopalatine ganglion; Trigeminal ganglion

Indexed keywords

FLUOROGOLD; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; ISOPROPAMIDE IODIDE; MONOCLONAL ANTIBODY;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INNERVATION; BRAIN BLOOD VESSEL; CELL STRUCTURE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; NERVE CELL; NERVE FIBER; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; RAT; SUBARACHNOID SPACE; TRIGEMINUS GANGLION;

EID: 2642521386     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000121234.42748.F6     Document Type: Article

References (47)

1. Arbab MAR, Wiklund L, Svendgaard NA (1986) Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat. Neuroscience 19:695-708
2. Arimura A (1998) Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine and nervous systems. Jpn J Physiol 48:301-331
3. Berghorn KA, Bonnett JH, Hoffman GE (1994) cFos immunoreactivity is enhanced with biotin amplification. J Histochem Cytochem 42:1635-1642
4. Bleys RLAW, Groen GJ, Hommersom RF (1996) Neural connections in and around the cavernous sinus in rat, with special reference to cerebrovascular innervation. J Comp Neurol 369:277-291
5. Bleys RLAW, Thrasivoulou C, Cowen T (2001) Cavernous sinus ganglia are sources for parasympathetic innervation of cerebral arteries in rat. J Cereb Blood Flow Metab 21:149-156
6. Edvinsson L, Brodin E, Jansen I, Uddman R (1988) Neurokinin A in cerebral vessels: characterization, localization and effects in vitro. Regul Pept. 20:181-197
7. Edvinsson L, Hara H, Uddman R (1989) Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: colocalization with different peptides. J Cereb Blood Flow Metab 9:212-218
8. Edvinsson L, Elsås T, Suzuki N, Shimizu T, Lee TJ (2001) Origin and co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat. Microsc Res Tech 53:221-228
9. Elsas T, Uddman R, Sundler F (1996) Pituitary adenylate cyclase-activating polypeptide-immunoreactive nerve fibers in the cat eye. Lab Invests 234:573-580
10. 1R) in rat cerebral blood vessels: Relation to PACAP and VIP containing nerves. J Cereb Blood Flow Metab 20:1205-1214
11. Gulbenkian S, Uddman R, Edvinsson L (2001) Neuronal messengers in the human cerebral circulation. Peptides 22:995-1007
12. Handa Y, Caner H, Hayashi M, Tamamaki N, Nojyo Y (1990) The distribution pattern of the sympathetic nerve fibers to the cerebral arterial system in rat as revealed by anterograde labeling with WGA-HRP. Exp Brain Res 82:493-498
13. Hannibal J, Mikkelsen JD, Clausen H, Holst JJ, Wulf B, Fahrenkrug J (1995) Gene expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat hypothalamus. Regul Pept 55:113-148
14. Hara H, Weir B (1986) Pathway of acetylcholinesterase containing nerves to the major cerebral arteries in rats. J Comp Neurol 250:245-252
15. Hara H, Weir B (1988) Pathway of nerves with vasoactive intestinal-polypeptide-like immunoreactivity to the major cerebral arteries of the rat. Cell Tissue Res 251:275-280
16. Hara H, Jansen I, Ekman R, Hamel E, MacKenzie ET, Uddman R, Edvinsson L (1989) Acetycholine and vasoactive intestinal peptide in cerebral blood vessels: effect of extirpation of the sphenopalatine ganglion. J Cereb Blood Flow Metab 9:204-211
17. Hara H, Zhang Q, Kuroyanagi T, Kobayashi S (1993) Parasympathetic cerebro-vascular innervation: An anterograde tracing from the sphenopalatine ganglion in the rat. Neurosurgery 32:822-827
18. Hardebo JE, Sukzuki N, Owman C (1994) Dynorphin B is present in sensory and parasympathetic pial arteries. J Auton Nerv Syst 47:171-176
19. Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings R, Robberecht P, Said SI, Sreedharan SP, Wank SA, Waschek JA (1998) International Union of Pharmacology XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev 50:265-270
20. Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S (1993) Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 11:333-342
21. Huang M, Shirahase H, Porstad OP (1993) Comparative study of vascular relaxation and receptor binding by PACAP and VIP. Peptides 14:755-762
22. Kausz M, Arimura A, Koves K (1998) Distribution and somatotopical localization of pituitary adenylate cyclase activating polypeptide (PACAP) in the trigeminal ganglion of cats and rat. Ann N Y Acad Sci 865:529-532
23. Knutsson M, Edvinsson L (2002) Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia. Neuroreport 13:507-509
24. Kobayashi H, Uezono Y, Ueno S, Izumi F (1994) Pituitary adenylate cyclase-activating polypeptides (PACAPs) increase cAMP in rat cerebral microvessels. Brain Res 647:145-147
25. Lazarov NE (2002) Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus. Prog Neurobiol 66:19-59
26. Liu W, Møller M (2000) Innervation of the rat pineal gland by PACAP-immunoreactive nerve fibers originating in the trigeminal ganglion: a degeneration study. Cell Tissue Res 301:369-373
27. McCulloch J, Uddman R, Kingman TA, Edvinsson L (1986) Calcitonin gene-related peptide: functional role in cerebrovascular regulation. Proc Natl Acad Sci U S A 83:5731-5735
28. Mulder H, Uddman R, Moller K, Zhang Y-Z, Ekblad E, Alumets J, Sundler F (1994) Pituitary adenylate cyclase activating polypeptide expression in sensory neurons. Neuroscience 63:307-312
29. Mulder H, Uddman R, Moller K, Elsas T, Ekblad E, Alumets J, Sundler F (1995) Pituitary adenylate cyclase activating polypeptide is expressed in autonomic neurons. Regul Pept 59:121-128
30. Møller M, Baeres FM (2003) PACAP-containing intrapineal nerve fibers originate predominantly in the trigeminal ganglion: a combined retrograde tracing- and immunohistochemical study of the rat. Brain Res 984:160-169
31. Møller M, Fahrenkrug J, Hannibal J (1999) Innervation of the rat pineal gland by pituitary adenylate-cyclase activating polypeptide (PACAP)-immunoreacfive nerve fibres. Cell Tissue Res 296:247-257
32. Nielsen HS, Hannibal J, Fahrenkrug J (1998) Embryonic expression of pituitary adenylate cyclase-activating polypeptide in sensory and autonomic ganglia and in spinal cord of the rat. J Comp Neurol 394:403-415
33. Seebeck J, Lowe M, Kruse ML, Schmidt WE, Mehdom HM, Ziegler A, Hempelmann RG (2002) The vasorelaxant effect of pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in isolated rat basilar arteries is partially mediated by activation of nitrergic neurons. Regul Pept 107:115-123
34. Seki Y, Suzuki Y, Baskaya MK, Kano T, Saito K, Takayasu M, Shibuya M, Sugita K (1995) The effects of pituitary adenylate cyclase-activating polypeptide on cerebral arteries and vertebral artery flow in anesthetized dogs. Eur J Pharmacol 275:259-266
35. Spengler D, Waeber C, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, Journot L (1993) Differential signal transduction by five splice variants of the PACAP receptor. Nature 365:170-175
36. Sundler F, Ekblad E, Hannibal J, Moller K, Zhang Y-Z, Mulder H, Elsas T, Grunditz T, Danielsen N, Fahrenkrug J, Uddman R (1996) Pituitary adenylate cyclase-activating peptide in sensory and autonomic ganglia: Localization and regulation. Ann N Y Acad Science 805:410-426
37. Shimizu T (1994) Distribution and pathway of the cerebrovascular nerve fibers from the otic ganglion in the rat: anterograde tracing study. J Auton Nerv Syst 49:47-54
38. Suzuki N, Hardebo JE, Owman C (1988) Origins and pathways of cerebrovascular vasoactive intestinal polypeptide-positive nerves in rat. J Cereb Blood Flow Metab 8:697-712
39. Suzuki N, Hardebo JE, Owman C (1989) Origins and pathways of the cerebrovasular nerves storing substance P and calcitonin gene-related peptide in the rat. Neuroscience 21:427-438
40. Suzuki N, Hardebo JE, Owman C (1990) Origins and pathways of the choline acetyltransferase-positive parasympathetic nerve fibers to cerebral vessels in rat. J Cerebr Blood Flow Metab 10:399-408.
41. Tajti J, Uddman R, Möller S, Sundler F, Edvinsson L (1999) Messenger molecules and receptor mRNA in the human trigeminal ganglion. J Auton Nerv Syst 76:176-183
42. Uddman R, Edvinsson L, Ekman R, Kingman T, McCulloch J (1985) Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin-gene related peptide: trigeminal origin and coexistence with substance P. Neurosci Lett 62:131-136
43. Uddman R, Hara H, Edvinsson L (1989) Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunocytochemistry. J Auton Nerv Syst 26:69-75
44. Uddman R, Goadsby PJ, Jansen I, Edvinsson L (1993) PACAP, a VIP-like peptide: Immunohistochemical localization and effect upon cat pial arteries and cerebral blood flow. J Cereb Blood Flow Metab 13:291-297
45. Uddman R, Grunditz T, Kato J, Sundler F (1998) Distribution and origin of nerve fibers in the rat temporomandibular joint capsule. Anat Embryol (Berl) 197:273-282
46. Uddman R, Tajti J, Moller S, Sundler F, Edvinsson L (1999) Neuronal messengers and peptide receptors in the human sphenopalatine and otic ganglia. Brain Res 826:193-199
47. Zhang E, Mikkelsen JD, Moller M (1991) Tyrosine hydroxylase-and neuropeptide Y-immunoreactive nerve fibers in the pineal complex of untreated rats and rats following removal of the superior cervical ganglia. Cell Tissue Res 265:63-71