The vasorelaxant effect of pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in isolated rat basilar arteries is partially mediated by activation of nitrergic neurons

Regulatory Peptides

Volumn 107, Issue 1-3, 2002, Pages 115-123

  Seebeck, Jörg ^a   Löwe, Marcus ^a   Kruse, Marie Luise ^a   Schmidt, Wolfgang E ^b   Mehdorn, H Maximilian ^a   Ziegler, Albrecht ^a   Hempelmann, Ralf G ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b ST JOSEF HOSPITAL   (Germany)

Author keywords

Conotoxin; Cerebral arteries; Confocal microscopy; Pituitary adenylate cyclase activating polypetide; Vasoactive intestinal polypeptide; VPAC receptor

Indexed keywords

3 BROMO 7 NITROINDAZOLE; ATROPINE; CALCIUM CHANNEL N TYPE; CARBACHOL; FLUORESCENT DYE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 6-27; INDOMETACIN; N(G) NITROARGININE; OMEGA CONOTOXIN GVIA; SEROTONIN; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; ADCYAP1 PROTEIN, RAT; ENZYME INHIBITOR; NEURONAL NITRIC OXIDE SYNTHASE; NEUROPEPTIDE; NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; OMEGA CONOTOXIN;

ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BLOOD VESSEL TONE; CELL ACTIVATION; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; MALE; MYOGRAPHY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; RAT; VASODILATATION; ANIMAL; CONFOCAL MICROSCOPY; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMAL; BASILAR ARTERY; CALCIUM CHANNELS, N-TYPE; ENZYME INHIBITORS; FLUORESCENT DYES; IN VITRO; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; NEURONS; NEUROPEPTIDES; NITRIC-OXIDE SYNTHASE; OMEGA-CONOTOXINS; RATS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; VASOACTIVE INTESTINAL PEPTIDE; VASODILATION; ANIMALS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE;

EID: 0037098973     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(02)00072-1     Document Type: Article

References (29)

1. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
2. Pituitary adenylate cyclase-activating polypeptide and its receptors: From structure to functions
3. Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems
4. Vasoactive intestinal peptide (VIP) like peptides in the cerebral circulation of the cat
5. Immunohistochemical localization of the VIP1 receptor (VPAC1R) in rat cerebral blood vessels: Relation to PACAP and VIP containing nerves
6. Evidence that vasoactive intestinal polypeptide (VIP) mediates neurogenic vasodilation of feline cerebral arteries
7. Vasorelaxant effect of PACAP-27 on canine cerebral arteries and rat intracerebral arterioles
8. Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon
9. PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones
10. Pituitary adenylate cyclase-activating polypeptide expression and modulation of neuronal excitability in guinea pig cardiac ganglia
11. Vasoactive intestinal polypeptide induces neurogenic contraction of guinea-pig ileum. Involvement of acetylcholine and substance P
12. Selectivity of omega-conotoxin GVIA for n-type calcium channels in rat isolated small mesenteric arteries
13. Inhibition of central neurotransmitter release by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel
14. Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels
15. G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and Gbetagamma
16. K+ is an endothelium-derived hyperpolarizing factor in rat arteries
17. Regulation of the cerebral circulation: Role of endothelium and potassium channels
18. Mechanical properties of vascular smooth muscle cells in situ
19. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
20. Cholinergic-nitrergic transmitter mechanisms in the cerebral circulation
21. Mechanism of prejunctional muscarinic receptor-mediated inhibition of neurogenic vasodilation in cerebral arteries
22. Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21
23. Rapid tachyphylaxis to hemodynamic effects of PACAP-27 after inhibition of nitric oxide synthesis
24. Pituitary adenylate cyclase-activating polypeptide: A novel, long-lasting, endothelium-independent vasorelaxant
25. The induction of nitric oxide-mediated relaxation of human isolated pulmonary arteries by PACAP
26. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
27. Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block
28. 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase
29. Signal transduction and regulation in smooth muscle