Role of desensitization and subunit expression for kainate receptor- mediated neurotoxicity in murine neocortical cultures

Journal of Neuroscience Research

Volumn 55, Issue 2, 1999, Pages 208-217

  Jensen, Jette B ^a   Schousboe, Arne ^a   Pickering, Darryl S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Concanavalin A; Domoate; GluR6 7; GYKI 53655; KA2

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CONCANAVALIN A; DIZOCILPINE; DOMOIC ACID; GLUTAMIC ACID; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; MOUSE; NEOCORTEX; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; BENZODIAZEPINES; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; KAINIC ACID; MICE; NEOCORTEX; NEUROMUSCULAR DEPOLARIZING AGENTS; NEUROTOXINS; QUINOXALINES; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033556377     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990115)55:2<208::AID-JNR8>3.0.CO;2-P     Document Type: Article

References (47)

1. Bahn S, Volk B, Wisden W. 1994. Kainate receptor gene expression in the developing rat brain. J Neurosci 14:5525-5547.
2. + and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA. Neuroscience 54:1019-1034.
3. Berman FW, Murray TF. 1997. Domoic acid neurotoxicity in cultured cerebellar granule neurons is mediated predominantly by NMDA receptors that are activated as a consequence of excitatory amino acid release. J Neurochem 69:693-703.
4. Bettler B, Boulter J, Hermans-Borgmeyer I, O'Shea-Greenfield A, Deneris ES, Moll C, Borgmeyer U, Hollmann M, Heinemann S. 1990. Cloning of a novel glutamate receptor subunit GluR5: expression in the nervous system during development. Neuron 5:583-595.
5. Bleakman D, Ballyk BA, Schoepp DD, Palmer AJ, Bath CP, Sharpe EF, Woolley M., Bufton HR, Kamboj RK, Tarnawa I, Lodge D. 1996. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 35:1689-1702.
6. Choi DW. 1992. Excitotoxic cell death. J Neurobiol 23:1261-1276.
7. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proc Natl Acad Sci USA 90:755-759.
8. Egebjerg J, Bettler B, Hermans-Borgmeyer I, Heinemann S. 1991. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351:745-748.
9. Frandsen A, Schousboe A. 1990. Development of excitatory amino acid induced cytotoxicity in cultured neurons. Int J Devl Neurosci 8:209-216.
10. Hampson DR, Huang X-P, Wells JW, Walter JA, Wright JLC. 1992. Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain. Eur J Pharmacol 218:1-8.
11. Henley JM, Barnard EA. 1991. Comparison of solubilised kainate and (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate binding sites in chick cerebellum. J Neurochem 56:702-705.
12. Herb A, Burnashev N, Werner P, Sakmann B, Wisden W, Seeburg PH. 1992. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8:775-785.
13. Hollmann M, Heinemann S. 1994. Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
14. Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S. 1989. Cloning by functional expression of a member of the glutamate receptor family. Nature 342:643-648.
15. Huettner JE. 1990. Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by con A. Neuron 5:255-266.
16. Jensen JB, Schousboe A, Pickering DS. 1998a. AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization. Neurochem Int 32:505-513.
17. Jensen JB, Schousboe A, Pickering DS. 1998b. Development of calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured neocortical neurons visualized by cobalt staining. J Neurosci Res 54:273-281.
18. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. Larm JA, Beart PM, Cheung NS. 1997. Neurotoxin domoic acid produces cytotoxicity via kainate-and AMPA-sensitive receptors in cultured cortical neurons. Neurochem Int 31:677-682.
20. Larsson OM, Drejer J, Kvamme E, Svenneby G, Hertz L, Schousboe A. 1985. Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo. Int J Dev Neurosci 3:177-185.
21. Lerma J. 1997. Kainate reveals its targets. Neuron 19:1155-1158.
22. Lerma J, Paternain AV, Naranjo JR, Mellström B. 1993. Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Proc Natl Acad Sci USA 90:11688-11692.
23. Lomeli H, Wisden W, Köhler M, Keinänen K, Sommer B, Seeburg PH. 1992. High-affinity kainate and domoate receptors in rat brain. FEBS Lett 307:139-143.
24. Meldrum BS. 1992. Excitatory amino acid receptors and disease. Curr Opin Neurol Neurosurg 5:508-513.
25. Monaghan DT, Bridges RJ, Cotman CW. 1989. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 29:365-402.
26. Mossman T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immun Meth 65:55-63.
27. Ohno K, Okada M, Tsutsumi R, Kohara A, Yamaguchi T. 1997. Kainate excitotoxicity is mediated by AMPA-but not kainate-preferring receptors in embryonic rat hippocampal cultures. Neurochem Int 31:715-722.
28. Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A. 1993. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082.
29. Paschen W, Schmitt J, Gissel C, Dux E. 1997. Developmental changes of RNA editing of glutamate receptor subunits GluR5 and GluR6: in vivo versus in vitro. Dev Brain Res 98:271-280.
30. Paternain AV, Vicente A, Nielsen EØ, Lerma J. 1996. Comparative antagonism of kainate-activated kainate and AMPA receptors in hippocampal neurons. Eur J Neurosci 8:2129-2136.
31. Paternain AV, Morales M, Lerma J. 1995. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
32. Patneau DK, Wright PW, Winters C, Mayer ML, Gallo V. 1994. Glial cells of the oligodendrocyte lineage express both kainate-and AMPA-preferring subtypes of glutamate receptor. Neuron 12: 357-371.
33. Patneau DK, Vyklicky L, Mayer ML. 1993. Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J Neurosci 13:3496-3509.
34. Petralia RS, Wang Y-X, Wenthold RJ. 1994. Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7. In the rat nervous system using selective antipeptide antibodies. J Comp Neurol 349:85-110.
35. Rodriguez-Moreno A, Herreras O, Lerma J. 1997. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19:893-901.
36. Sahara Y, Noro N, Iida Y, Soma K, Nakamura Y. 1997. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. J Neurosci 17:6611-6620.
37. Sakimura K, Morita T, Kushiya E, Mishina M. 1992. Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate. Neuron 8:267-274.
38. Savidge JR, Bleckman D, Bristow DR. 1997. Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells. J Neurochem 69:1763-1766.
39. Schiffer HH, Swanson GT, Heinemann SF. 1997. Rat GluR7 and a carboxy-terminal splice variant. GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron 19:1141-1146.
40. Sheardown MJ, Nielsen EO, Hansen AJ, Jacobsen P, Honore T. 1990. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-574.
41. Sommer B, Burnashev N, Verdoorn TA, Keinänen K, Sakmann B, Seeburg PH. 1992. A glutamate receptor channel with high affinity for domoate and kainate. EMBO J 11:1651-1656.
42. Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
43. Vizi ES, Mike A, Tarnawa I. 1996. 2,3-Benzodiazepines (GYKI 52466 and analogs): Negative allosteric modulators of AMPA receptors. CNS Drug Rev 2:91-126.
44. Wilding TJ, Huettner JE. 1995. Differential antagonism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol Pharmacol 47:582-587.
45. Wisden W, Seeburg PH. 1993. A complex mosaic of high-affinity kainate receptors in rat brain. J Neurosci 13:3582-3598.
46. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL. 1986. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104-7108.
47. Zhou L-M, Gu Z-Q, Costa AM, Yamada KA, Mannson PE, Giordano T, Skolnick P, Jones KA. 1997. (2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors. J Pharmacol Exp Therap 280:422-427.