Synthesis of diastereoisomeric pairs of novel analogues of d4T having an isochroman glycon moiety; their enzymatic kinetic resolution, their enantiopure synthesis, molecular modeling and NMR structural study

Tetrahedron

Volumn 61, Issue 44, 2005, Pages 10583-10595

  Len, Christophe ^a,b   Pilard, Serge ^b   Lipka, Emmanuelle ^c   Vaccher, Claude ^c   Dubois, Marie Pierre ^d   Shrinska, Yana ^d   Tran, Vinh ^d   Rabiller, Claude ^d  

^a UNIVERSITÉ DE POITIERS   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c UNIV LILLE   (France)

^d UNIVERSITÉ DE NANTES   (France)

Author keywords

d4T Analogue synthesis; Enantiopure synthesis; Lipase resolution; Molecular modeling; NMR configuration attribution

Indexed keywords

1 (3 HYDROXYMETHYLISOCHROMAN 1 YL)THYMINE; 2 BROMOBENZALDEHYDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; AROMATIC COMPOUND; BENZALDEHYDE DERIVATIVE; ISOCHROMAN DERIVATIVE; MANNITOL; PYRIMIDINE NUCLEOSIDE DERIVATIVE; STAVUDINE; THYMINE DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; ENZYME KINETICS; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSESTERIFICATION;

EID: 25844525707     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.07.084     Document Type: Article

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