-
1
-
-
0035720354
-
Origins of cancer therapy
-
Papac Rj. Origins of cancer therapy. Yale J Biol Med. 2001;74:391-398.
-
(2001)
Yale J. Biol. Med.
, vol.74
, pp. 391-398
-
-
Papac, R.J.1
-
2
-
-
0001501849
-
The modifying influence of dichloroethyl sulfide on the induction of tumours in mice by tar
-
Berenblum, I. The modifying influence of dichloroethyl sulfide on the induction of tumours in mice by tar. J Pathol Bacteriol. 1929;32:425-434.
-
(1929)
J. Pathol. Bacteriol.
, vol.32
, pp. 425-434
-
-
Berenblum, I.1
-
3
-
-
0001005193
-
Experimental and clinical studies on the treatment of cancer by dichloroethylsulfide (mustard gas)
-
Adair FE, Bagg HJ. Experimental and clinical studies on the treatment of cancer by dichloroethylsulfide (mustard gas). Ann Surg. 1931;93:190-199.
-
(1931)
Ann. Surg.
, vol.93
, pp. 190-199
-
-
Adair, F.E.1
Bagg, H.J.2
-
4
-
-
78249277673
-
Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
-
Goodman LS, Wintrobe MM, Dameshek W, Goodman JJ, Gilman A. Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. JAMA. 1946;132:126-132.
-
(1946)
JAMA
, vol.132
, pp. 126-132
-
-
Goodman, L.S.1
Wintrobe, M.M.2
Dameshek, W.3
Goodman, J.J.4
Gilman, A.5
-
5
-
-
0001060019
-
The biological actions and therapeutic applications of beta-chloroethyl amines and sulfides
-
Gilman A, Philips FS. The biological actions and therapeutic applications of beta-chloroethyl amines and sulfides. Science. 1946; 103:409-415.
-
(1946)
Science
, vol.103
, pp. 409-415
-
-
Gilman, A.1
Philips, F.S.2
-
6
-
-
0000636701
-
The initial clinical trial of nitrogen mustard
-
Gilman A. The initial clinical trial of nitrogen mustard. Am J Surg. 1963;105:574-578.
-
(1963)
Am. J. Surg.
, vol.105
, pp. 574-578
-
-
Gilman, A.1
-
7
-
-
0023605277
-
Structural modifications of the vinca alkaloids
-
Johnson IS, Cullinan GJ, Boder GB, Grindey CB, Laguzza BC. Structural modifications of the vinca alkaloids. Cancer Treat Rev. 1987; 14:407-410.
-
(1987)
Cancer Treat. Rev.
, vol.14
, pp. 407-410
-
-
Johnson, I.S.1
Cullinan, G.J.2
Boder, G.B.3
Grindey, C.B.4
Laguzza, B.C.5
-
8
-
-
0030695955
-
Systems for identifying new drugs are often faulty
-
Gura T. Systems for identifying new drugs are often faulty. Science. 1997;278:1041-1042.
-
(1997)
Science
, vol.278
, pp. 1041-1042
-
-
Gura, T.1
-
9
-
-
0036549015
-
Conditional mouse models of sporadic cancer
-
Jonkers J, Berns A. Conditional mouse models of sporadic cancer. Nat Rev Cancer. 2002;2:251-265.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 251-265
-
-
Jonkers, J.1
Berns, A.2
-
10
-
-
0043069547
-
Opinion: Understanding "global" systems biology: Metabonomics and the continuum of metabolism
-
Nicholson JK, Wilson ID. Opinion: understanding "global" systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov. 2003;2:668-676.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 668-676
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
12
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004; 22:2954-2963.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
13
-
-
0035953550
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
-
Johnson L, Mercer K, Greenbaum D, et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 2001;410:1111-1116.
-
(2001)
Nature
, vol.410
, pp. 1111-1116
-
-
Johnson, L.1
Mercer, K.2
Greenbaum, D.3
-
14
-
-
0035709416
-
Functional genomics and target validation approaches using anti-sense oligonucleotide technology
-
Dean NM. Functional genomics and target validation approaches using anti-sense oligonucleotide technology. Curr Opin Biotechnol. 2001;12:622-625.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 622-625
-
-
Dean, N.M.1
-
15
-
-
0042530108
-
Antisense and RNAi: Powerful tools in drug target discovery and validation
-
Lavery KS, King TH. Antisense and RNAi: powerful tools in drug target discovery and validation. Curr Opin Drug Discov Devel. 2003;6:561-569.
-
(2003)
Curr. Opin. Drug Discov. Devel.
, vol.6
, pp. 561-569
-
-
Lavery, K.S.1
King, T.H.2
-
17
-
-
0037816160
-
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
-
Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A. 2003;100:8430-8435.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8430-8435
-
-
Siegel, P.M.1
Shu, W.2
Cardiff, R.D.3
Muller, W.J.4
Massague, J.5
-
18
-
-
2142659368
-
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice
-
Hiesberger T, Bai Y, Shao X, et al. Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest. 2004; 113:814-825.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 814-825
-
-
Hiesberger, T.1
Bai, Y.2
Shao, X.3
-
19
-
-
0033523233
-
Anticancer agents targeting signaling molecules and cancer cell environment: Challenges for drug development?
-
Gelmon KA, Eisenhauer EA, Harris AL, Ratain MJ, Workman P. Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst. 1999;91:1281-1287.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1281-1287
-
-
Gelmon, K.A.1
Eisenhauer, E.A.2
Harris, A.L.3
Ratain, M.J.4
Workman, P.5
-
20
-
-
0021352273
-
Clinical development of anticancer agents - A National Cancer Institute perspective
-
Marsom S, Wittes R. Clinical development of anticancer agents - a National Cancer Institute perspective. Cancer Treat Rep. 1984;68:77-85.
-
(1984)
Cancer Treat Rep.
, vol.68
, pp. 77-85
-
-
Marsom, S.1
Wittes, R.2
-
21
-
-
0036554730
-
Endpoints in cancer clinical trials and the drug approval process
-
Schilsky RL. Endpoints in cancer clinical trials and the drug approval process. Clin Cancer Res. 2002;8:935-938.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 935-938
-
-
Schilsky, R.L.1
-
22
-
-
0035154256
-
Clinical trial designs for cytostatic agents: Are new approaches needed?
-
Korn EL, Arbuck SG, Pluda JM, Simon R, Kaplan RS, Christian MC. Clinical trial designs for cytostatic agents: are new approaches needed? J Clin Oncol. 2001;19:265-272.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 265-272
-
-
Korn, E.L.1
Arbuck, S.G.2
Pluda, J.M.3
Simon, R.4
Kaplan, R.S.5
Christian, M.C.6
-
23
-
-
2342663709
-
Molecular imaging of tumor angiogenesis
-
Schirner M, Menrad A, Stephens A, Frenzel T, Hauff P, Licha K. Molecular imaging of tumor angiogenesis. Ann NY Acad Sci. 2004;1014:67-75.
-
(2004)
Ann. NY Acad. Sci.
, vol.1014
, pp. 67-75
-
-
Schirner, M.1
Menrad, A.2
Stephens, A.3
Frenzel, T.4
Hauff, P.5
Licha, K.6
-
24
-
-
0041323345
-
Strategy for the development of novel anticancer drugs
-
Saijo N, Tamura T, Nishio K. Strategy for the development of novel anticancer drugs. Cancer Chemotber Pharmacol. 2003;52 (Suppl 1):S97-101.
-
(2003)
Cancer Chemotber. Pharmacol
, vol.52
, Issue.SUPPL. 1
-
-
Saijo, N.1
Tamura, T.2
Nishio, K.3
-
25
-
-
0037112181
-
Randomized discontinuation design: Application to cytostatic antineoplastic agents
-
Rosner GL, Stadler W, Ratain MJ. Randomized discontinuation design: application to cytostatic antineoplastic agents. J Clin OncoL 2002;20:4478-4484.
-
(2002)
J. Clin. OncoL.
, vol.20
, pp. 4478-4484
-
-
Rosner, G.L.1
Stadler, W.2
Ratain, M.J.3
-
27
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003;290:2149-2158.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
28
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol. 2003;21:2237-2246.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
29
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch Tj, Bell DW, Sordella. R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
30
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
31
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101:13306-13311.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
32
-
-
4344598294
-
Pharmacogenomics. Cancer sharpshooters rely on DNA tests for a better aim
-
Couzin J. Pharmacogenomics. Cancer sharpshooters rely on DNA tests for a better aim. Science. 2004;305:1222-1223.
-
(2004)
Science
, vol.305
, pp. 1222-1223
-
-
Couzin, J.1
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