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A solid containing building blocks with formal charges is a salt, and there is no need to describe it as an adduct, molecular adduct, proton-transfer solid, molecular salt, or variations hereof.
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25844518704
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CSD codes: OCAYUM, OCASAT, and POFPAB
-
CSD codes: OCAYUM, OCASAT, and POFPAB.
-
-
-
-
87
-
-
25844438433
-
-
CSD codes: GURVOE, GURVUK, LUDFUL, UNECAR, ZUPKUQ, and ZUPLAX
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CSD codes: GURVOE, GURVUK, LUDFUL, UNECAR, ZUPKUQ, and ZUPLAX.
-
-
-
-
88
-
-
25844468566
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-
CSD codes: BEQWAV, FIHYEA, FIJCIK, FIJCUW, HUPPOX, MUFNIK, NOPXIZ, OJENIA, PULWUO, RAPHAR, SUXVOW, UDUZIC, UDOZOI, UHELUO, XUNGIW, and XUNGOC
-
CSD codes: BEQWAV, FIHYEA, FIJCIK, FIJCUW, HUPPOX, MUFNIK, NOPXIZ, OJENIA, PULWUO, RAPHAR, SUXVOW, UDUZIC, UDOZOI, UHELUO, XUNGIW, and XUNGOC.
-
-
-
-
89
-
-
25844484783
-
-
CSD code: POFPEF
-
CSD code: POFPEF.
-
-
-
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90
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25844513672
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-
CSD codes: CUFSET, LUSWEB, PANYIM, PANZEJ, PAPDIT, PAPFOB, UNEBOE, WUKREZ, and WUKROJ
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CSD codes: CUFSET, LUSWEB, PANYIM, PANZEJ, PAPDIT, PAPFOB, UNEBOE, WUKREZ, and WUKROJ.
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-
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91
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25844502571
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CSD codes: AJAKEB, AJAKIF, ASAXOH, ASAXUN, BUDWEC, BUDZUV, BUFBIP, BUFQAU, LUNMEM, LUNMIC, LUNMOW, and VAKTOR
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CSD codes: AJAKEB, AJAKIF, ASAXOH, ASAXUN, BUDWEC, BUDZUV, BUFBIP, BUFQAU, LUNMEM, LUNMIC, LUNMOW, and VAKTOR.
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92
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16244411299
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95
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25844484143
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note
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There are, of course, other aspects that need to be considered e.g., solubility differences between drug and CA (if the co-crystals are to be prepared via solution-based methods) before embarking upon a series of co-crystallizations.
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97
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Taniguch, T.1
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0001736323
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0006944604
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0031780159
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If the acid is too strong, the proton will be transferred to the nitrogen atom resulting in an ionic compound and not a co-crystal. Some examples of crystal engineering of ionic systems include e.g.: J. A. Swift, A. M. Pivovar, A. M. Reynolds and M. D. Ward, J. Am. Chem. Soc., 1998, 120, 5887;
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Aakeröy, C.B.1
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25844482652
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note
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a = 4.72 ± 0.10 and 5.85 ± 0.18 for pyridyl and benzimidazol-1-yl moieties, respectively. The calculations were performed using Advanced Chemistry Development (ACD/Labs) Software Solaris V4.76 (© 1994-2005 ACD/Labs).
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128
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