Anti-inflammatory effect of Viscum album agglutinin-I (VAA-I): Induction of apoptosis in activated neutrophils and inhibition of lipopolysaccharide-induced neutrophilic inflammation in vivo

Clinical and Experimental Immunology

Volumn 137, Issue 2, 2004, Pages 272-278

  Lavastre, V ^a   Cavalli, H ^a   Ratthe, C ^a   Girard, D ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Apoptosis; Inflammation; Paxillin; Vimentin; Viscum album

Indexed keywords

ANTIINFLAMMATORY AGENT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PLANT LECTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VISCUM ALBUM AGGLUTININ 1; VISCUM ALBUM EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEUKOCYTE ACTIVATION; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VISCUM ALBUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CYTOKINES; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PLANT PREPARATIONS; PLANT PROTEINS; TOXINS, BIOLOGICAL;

EID: 3542996933     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02545.x     Document Type: Article

References (26)

1. Savill J. Haslett C. Granulocyte clearance by apoptosis in the resolution of inflammation. Semin Cell Biol 1995; 6:385-93.
2. Ward I, Dransfield I, Chilvers ER, Haslett I, Rossi AG. Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets. Trends Pharmacol Sci 1999; 20:503-9.
3. Savill J. Apoptosis in resolution of inflammation. J Leukoc Biol 1997; 61:375-80.
4. Ren Y, Savill J. Apoptosis: the importance of being eaten. Cell Death Diff 1998; 5:563-8.
5. Hostanska K, Hajto T, Weber K et al. A natural immunity-activating plant lectin, Viscum album agglutinin-I, induces apoptosis in human lymphocytes, monocytes, monocytic THP-1 cells and murine thymocytes. Nat Immun 1996-97; 15:295-311.
6. Savoie A, Lavastre V, Pelletier M, Hajto T, Hostanska K, Girard D. Activation of human neutrophils by the plant lectin Viscum album agglutinin-I. modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis. J Leukoc Biol 2000; 68:845-53.
7. Lavastre V, Pelletier M, Sailer R, Hostanska K, Girard D. Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases. J Immunol 2002; 168:1419-27.
8. Hostanska K, Hajto T, Spagnoli GC, Fischer J, Lentzen H, Herrmann R. A plant lectin derived from Viscum album induces cytokine gene expression and protein production in cultures of human peripheral blood mononuclear cells. Nat Immun 1995; 14:295-304.
9. Hajto T, Hostanska K, Frei K, Rordorf C, Gabius HJ. Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 1990; 50:3322-6.
10. Hajto T, Hostanska K, Weber K et al. Effect of a recombinant lectin, Viscum album agglutinin on the secretion of interleukin-12 in cultured human peripheral blood mononuclear cells and on NK-cell-mediated cytotoxicity of rat splenocytes in vitro and in vivo. Nat Immun 1998; 16:34-46.
11. Olsnes S, Stirpe F, Sandvig K, Pihl A. Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J Biol Chem 1982; 257:13263-70.
12. Hajto T, Hostanska K, Fischer J, Saller R. Immunomodulatory effects of Viscum album agglutinin-I on natural immunity. Anticancer Drugs 1997; 8:S43-6.
13. Kovacs E. Serum levels of IL-12 and the production of IFN-gamma, IL-2 and IL-4 by peripheral blood mononuclear cells (PBMC) in cancer patients treated with Viscum album extract. Biomed Pharmacother 2000; 54:305-10.
14. Gorter RW, van Wely M, Stoss M, Wollina U. Subcutaneous infiltrates induced by injection of mistletoe extracts (Iscador). Am J Ther 1998; 5:181-7.
15. Moulding DA, Hart CA, Edwards SW. Regulation of neutrophil FcgammaRIIIb (CD16) surface expression following delayed apoptosis in response to GM-CSF and sodium butyrate. J Leukoc Biol 1999; 65:875-82.
16. Ratthé C, Pelletier M, Roberge CJ, Girard D. Activation of human neutrophils by the pollutant sodium sulfite: effect on cytokine production, chemotaxis and cell surface expression of cell adhesion molecules. Clin Immunol 2002; 105:169-75.
17. Pelletier M, Roberge CJ, Gauthier M, Vandal K, Tessier PA, Girard D. Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo. J Leukoc Biol 2001; 70:367-73.
18. Klein JB, Buridi A, Coxon PY et al. Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis. Cell Signal 2001; 13:335-43.
19. Hachiya O, Takeda Y, Miyata H, Watanabe H, Yamashita T, Sendo F. Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-alpha-induced human neutrophil apoptosis in vitro. Microbiol Immunol 1995; 39:715-23.
20. Siegle I, Fritz P, McClellan M, Gutzeit S, Murdter TE. Combined cytotoxic action of Viscum album agglutinin-1 and anticancer agents against human A549 lung cancer cells. Anticancer Res 2001; 21:2687-91.
21. Pelletier M, Lavastre V, Savoie A et al. Modulation of interleukin-15-induced human neutrophil responses by the plant lectrin Viscum album agglutinin-I. Clin Immunol 2001; 101:229-36.
22. Ottonello L, Cutolo M, Frumento G et al. Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines. Rheumatology 2002; 41:1249-60.
23. Gorter RW, Joller P, Stoss M. Cytokine release of a keratinocyte model after incubation with two different Viscum album L. extracts. Am J Ther 2003; 10:40-7.
24. Ribereau-Gayon G, Dumont S, Muller C, Jung ML, Poindron P, Anton R. Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett 1996; 109:33-8.
25. Lloyd AR, Oppenheim JJ. Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today 1992; 13:169-72.
26. Cassatella MA. The production of cytokines by polymorphonuclear neutrophils. Immunol Today 1995; 16:21-6.