Isolation and quantification of chitin-binding mistletoe lectin from mistletoe extracts and validation of this method

Arzneimittel-Forschung/Drug Research

Volumn 54, Issue 4, 2004, Pages 230-239

  Franz, Mirita ^a   Vollmer, Simone ^a   Wacker, Roland ^a   Jäger, Sebastian ^b   Scheer, Rainer ^b   Stoeva, Stanka ^a   Voelter, Wolfgang ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Carl Gustav Carus Institut   (Germany)

Author keywords

Mistletoe extracts; Mistletoe lectin, chitin binding, isolation and quantification

Indexed keywords

CHITIN BINDING MISTLETOE LECTIN; UNCLASSIFIED DRUG; VISCUM ALBUM LECTIN;

AFFINITY CHROMATOGRAPHY; ANALYTIC METHOD; ARTICLE; CALCULATION; DRUG IDENTIFICATION; DRUG ISOLATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

VISCUM ALBUM;

EID: 1942532012     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296964     Document Type: Article

References (27)

1. Gabius, H.-J., ISI Atlas SCI Biochem. 1, 210 (1988)
2. Beuth, J., Clinical relevance of immunoactive mistletoe lectin-I. Anticancer Drugs 8, 53 (1997)
3. Franz, H., Ziska, P., Kindt, A., Isolation and properties of three lectins from mistletoe (Viscum album L). Biochem. J. 195, 481 (1981)
4. Bantel, H., Engels, I. H., Voelter, W. et al., Mistletoe Lectin Activates Caspase-8/FLICE Independently of Death Receptor Signaling and Enhances Anticancer Drug-induced Apoptosis. Cancer Res. 59, 2083 (1999)
5. Baxevanis, C. N., Voutsas, I. F., Soler, M. H. et al., Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. Immunopharmacol. Immunotoxicol. 20, 355 (1998)
6. Alovskaya, A. A., Safronova, V. G., Kornilov, V. V. et al., Viscum Modulates the Neutrophil Respiratory Burst Induced by a Chemotactic Peptide Biophys. 45, 669 (2000)
7. Hajto, T., Hostanska, K., Fornalski, M. et al., Antitumor activity of beta-galactoside specific mistletoe lectin as immunomodulator applied by mistletoe extracts (Iscador). Dtsch. Zschr. Onkol. 23, 1 (1991)
8. Franz, H. (ed., Advances in Lectin Research, Vol. 4, p. 33, Springer Verlag, Berlin (1991)
9. Stoeva, S., Maier, T., Soler, M. H. et al., Carbohydrate Chains and Their Binding Sites in Mistletoe Lectin I. Polish J. Chem. 73, 125 (1999)
10. Voelter, W., Soler, M. H., Stoeva, S. et al., First three-dimensional model building study of the A chain of mistletoe lectin I. GIT Lab. J. 1, 32 (1997)
11. Eschenburg, S., Krauspenhaar, R., Mikhailov, A. et al., Primary Structure and Molecular Modeling of Mistletoe Lectin I from Viscum album. Biochem. Biophys. Res. Commun. 247, 367 (1998)
12. Soler, M. H., Stoeva, S., Schwamborn, C. et al., Complete Amino Acid Sequence of the A Chain of Mistletoe Lectin I. FEBS Lett. 399, 153 (1996)
13. Soler, M. H., Stoeva, S., Voelter, W., Complete Amino Acid Sequence of the B Chain of Mistletoe Lectin I. Biochem. Biophys. Res. Commun. 246, 596 (1998)
14. Krauspenhaar, R., Eschenburg, S., Perbandt, M. et al., Crystal Structure of Mistletoe Lectin I from Viscum album. Biochem. Biophys. Res. Commun. 257, 418 (1999)
15. Peumans, W. J., Verhaert, P., Pfüller, U. et al., Isolation and partial characterization of a small chitin-binding lectin from mistletoe (Viscum album). FEBS Lett. 396, 261 (1996)
16. Voelter, W., Wacker, R., Franz, M. et al., Complete Structural Characterization of a Chitin-Binding Lectin from Mistletoe Extracts. J. Prakt. Chem. 342, 812 (2000)
17. Stoeva, S., Franz, M., Wacker, R. et al., Primary structure, isoforms, and molecular modeling of a chitin-binding mistletoe lectin. Arch. Biochem. Biophys. 392, 23 (2001)
18. Andersen, N. H., Cao, B., Rodriguez-Romero, A. et al., Hevein: NMR assignment and assessment of solution-state folding for the agglutinin-toxin motif. Biochem. 32, 1407 (1993)
19. Peitsch, M. C., Bio/Technology 13, 658 (1995)
20. Koo, J. C., Lee, S. Y., Chun, H. J. et al., Two hevein homologs isolated from the seed of Pharbitis nil L. exhibit potent antifungal activity. Biochem. Biophys. Acta 1382, 80-90 (1998)
21. Stanford, A., Bevan, M., Northcote, D., Differential expression within a family of novel wound-induced genes in potato. Mol. Gen. Genet. 215, 200 (1989)
22. Beintema, J. J., Peumans, W. J., The primary structure of stinging nettle (Urtica dioica) agglutinin. A two-domain member of the hevein family. FEBS Lett. 299, 131 (1992)
23. Klein, R., Franz, M., Wacker, R. et al., Demonstration of antibodies to different epitopes of the chitin-binding mistletoe lectin (cbML) in tumor patients before and during therapy with an aqueous mistletoe extract (in preparation)
24. Eifler, R., Pfüller, K., Göckeritz, W. et al., Improved procedures for isolation of mistletoe lectins and their subunits: lectin pattern of the European mistletoe. In: J. Basu, M. Kundu, P. Chakrabarti (eds.), Lectins: Biology, Biochemistry, Clinical Biochemistry, Vol. 9, p. 144, Wiley Eastern Ltd., New York (1993)
25. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use: Q2A, Validation of Analytical Procedures (Definitions and Terminology)
26. ICH: International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use: Q2B, Validation of Analytical Procedures, Analytical Validation (Methodology)
27. Validat 2000 Onlinehandbuch, Headwork-Consulting GmbH, Bonner Talweg 55, D-53113 Bonn