Inhibition of Ras attenuates the course of experimental autoimmune neuritis

Journal of Neuroimmunology

Volumn 168, Issue 1-2, 2005, Pages 46-55

  Kafri, Michal ^a   Kloog, Yoel ^a   Korczyn, Amos D ^a   Ferdman Aronovich, Ramona ^a   Drory, Vivian ^a   Katzav, Aviva ^a   Wirguin, Itzhak ^b   Chapman, Joab ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Experimental autoimmune neuritis; Farnesylthiosalicylate; Guillain Barr syndrome; Nerve conduction; Ras; Rat

Indexed keywords

MYELIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SODIUM CHLORIDE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CONTROLLED STUDY; DEMYELINATING DISEASE; EXPERIMENTAL AUTOIMMUNE NEURITIS; FEMALE; IMMUNIZATION; INFLAMMATION; MEASUREMENT; NERVE CONDUCTION; NEURITIS; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; ROTAROD TEST; SCORING SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; CELL PROLIFERATION; CELLS, CULTURED; CONCANAVALIN A; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG INTERACTIONS; ELECTROMYOGRAPHY; ENZYME INHIBITORS; FARNESOL; FEMALE; LYMPHOCYTES; MOTOR ACTIVITY; MYCOBACTERIUM TUBERCULOSIS; MYELIN PROTEINS; NEURAL CONDUCTION; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; RAS PROTEINS; RATS; RATS, INBRED LEW; ROTAROD PERFORMANCE TEST; SALICYLIC ACIDS; SEVERITY OF ILLNESS INDEX;

EID: 25844440047     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.07.008     Document Type: Article

References (60)

1. Z. Aharonson, M. Gana-Weisz, T. Varsano, R. Haklai, D. Marciano, and Y. Kloog Stringent structural requirements for anti-Ras activity of S-prenyl analogues Biochim. Biophys. Acta 1406 1998 40 50
2. J. Archelos, M. Maurer, S. Jung, K. Toyka, and H. Hartung Suppression of experimental allergic neuritis by an antibody to the intercellular adhesion molecule ICAM-1 Brain 116 1993 1043 1058
3. X. Bai, J. Zhu, G. Zhang, G. Kaponides, B. Hojeberg, P.V.D. Meide, and H. Link IL-10 suppresses experimental autoimmune neuritis and down regulates TH1-type immune responses Clin. Immunol. Immunopathol. 83 1997 117 126
4. C. Bolton, J. On, S. Allen, and D. Baker Regulation of chronic relapsing experimental allergic encephalomyelitis by endogenous and exogenous glucocorticoids Int. Arch. Allergy Immunol. 114 1997 74 80
5. D. Buscher, R. Hipskind, S. Krautwald, T. Reimann, and M. Baccarini Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages Mol. Cell. Biol. 15 1995 466 475
6. A. Cox, M. Hisaka, J. Buss, and C. Der Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein Mol. Cell. Biol. 12 1992 2606 2615
7. B.G. Cragg, and P.K. Thomas Changes in nerve conduction in experimental allergic neuritis J. Neurol. Neurosurg. Psychiatry 27 1964 106 115
8. J. Downward Ras signaling and apoptosis Curr. Opin. Genet. Dev. 8 1998 49 54
9. J. Downward, J.D. Graves, P.H. Warne, S. Rayter, and D.A. Cantrell Stimulation of p21ras upon T-cell activation Nature 346 1990 719 723
10. Y. Egozi, B. Weisz, M. Gana-Weisz, G. Ben-Baruch, and Y. Kloog Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist Int. J. Cancer 80 1999 911 918
11. U. Enders, K. Toyka, H. Hartung, and R. Gold Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) in Lewis rat J. Neuroimmunol. 76 1997 112 116
12. C. Gabriel, N. Gregson, E. Redford, M. Davies, K. Smith, and R. Huges Human immunoglobulin ameliorates rat experimental autoimmune neuritis Brain 120 1997 1533 1540
13. M. Gana-Weisz, R. Haklai, D. Marciano, Y. Egozi, G. Ben-Baruch, and Y. Kloog The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation Biochem. Biophys. Res. Commun. 239 1997 900 904
14. J. Gomez, C. Martinez, B. Fernandez, A. Garcia, and A. Rebollo Ras activation leads to cell proliferation or apoptotic cell death upon interlukin-2 stimulation or lymphokine deprivation, respectively Eur. J. Immunol. 27 1997 1610 1618
15. T.G.-B.S.S. Group Plasmapheresis and acute Guillain-Barré syndrome Neurology 35 1985 1096 1104
16. A.F. Hahn Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies Rev. Neurol. Paris 152 1996 328 332
17. R. Haklai, M.G. Weisz, G. Elad, A. Paz, D. Marciano, Y. Egozi, G. Ben-Baruch, and Y. Kloog Dislodgment and accelerated degradation of Ras Biochemistry 37 1998 1306 1314
18. M.C. Harrisingh, and A.C. Lloyd Ras/Raf/ERK signalling and NF1 Cell Cycle 10 2004 1255 1258
19. H. Hartung, and K. Toyka T-cell and macrophage activation in experimental autoimmune neuritis and Guillain-Barré syndrome Ann. Neurol. 27 1990 S57 S63 (Suppl)
20. H. Hartung, B. Schafer, W. Fierz, K. Heininger, and K. Toyka Cyclosporin A prevents P2 T cell line-mediated experimental autoimmune neuritis (AT-EAN) in rat Neurosci. Lett. 83 1987 195 200
21. S.W. Henning, and D.A. Cantrell GTPases in antigen receptor signalling Curr. Opin. Immunol. 10 1998 322 329
22. P.M. Hoffman, J.M. Powers, M.J. Weise, and S.W. Brotstoff Experimental allergic neuritis: I. Rat strain differences in the response to bovine myelin antigen Brain Res. 195 1980 355 362
23. R. Hughes, M. Kadlubowski, and A. Hufschmidt Treatment of acute inflammatory polyneuropathy Ann. Neurol. 9 1981 125 131 (Suppl)
24. T. Joneson, and D. Bar-Sagi Ras effectors and their role in mitogenesis and oncogenesis J. Mol. Med. 75 1997 587 593
25. C.H. June Signal transduction in T cells Curr. Opin. Immunol. 3 1991 287 293
26. S. Jung, S. Kramer, H. Schluesener, T. Hunig, K. Toyka, and H. Hartung Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta J. Immunol. 148 1992 3768 3775
27. S. Jung, K. Toyka, and H. Hartung Tcell directed immunotherapy of inflammatory demyelination in the peripheral nervous system. Potent suppression of the effector phase of experimental autoimmune neuritis by anti-CD2 antibodies Brain 119 1996 1079 1090
28. M. Kadlubowski, and R. Hughes Identification of the neuritogen for experimental allergic neuritis Nature 277 1979 140 141
29. M. Kadlubowski, R. Hughes, and N. Gregson Experimental allergic neuritis in the Lewis rat: characterization of the activity of peripheral myelin and its major basic protein P2 Brain Res. 184 1980 439 454
30. M. Kafri, V. Drory, N. Wang, R. Rabinowitz, A. Korczyn, and J. Chapman Assessment of experimental autoimmune neuritis in the rat by electrophysiology of the tail nerve Muscle Nerve 25 2002 51 57
31. B. Kallen, M. Dohlsten, and H. Klementsoon Effect of cyclophosphamide pretreatment on autoimmune encephalomyelitis in rats Acta Neurol. Scand. 73 1986 338 344
32. D.M. Karussis, O. Abramsky, N. Grigoriadis, J. Chapman, R. Mizrachi-Koll, H. Niv, and Y. Kloog The Ras-pathway inhibitor, s-trans-trans- farnesylthiosalicylic acid (FTS), suppress experimental autoimmune encephalomyelitis J. Neuroimmunol. 120 2001 1 9
33. K. Kato, A.D. Cox, M.M. Hisaka, S.M. Graham, J.E. Buss, and C.J. Der Isoprenoid addition to Ras is the critical modification for its membrane association and transforming activity Proc. Natl. Acad. Sci. U. S. A. 89 1992 6403 6407
34. A. Katzav, Y. Kloog, A.D. Korczyn, H. Niv, D.M. Karussis, N. Wang, R. Rabinowitz, M. Blank, Y. Shoenfeld, and J. Chapman Treatment the MRL/lpr mice, a genetic autoimmune model, with the ras inhibitor, with the Ras inhibitor, farnesylthiosalicylic acid (FTS) Clin. Exp. Immunol. 126 2001 570 577
35. B. Kieseier, K. Krivacic, S. Jung, H. Pischel, K. Toyka, R.M. Ransohoff, and H. Hartung Sequential expression of chemokines in experimental autoimmune neuritis J. Neuroimmunol. 110 2000 121 129
36. Y. Kloog, A.D. Cox, and M. Sinensky Concepts in Ras-directed therapy Expert Opin. Investig. Drugs 8 1999 1 20
37. A. Korczyn, and P. Nisipeanu Plasmapheresis in Guillain-Barré syndrome Eur. J. Neurol. 3 1996 417 423
38. B. Li, M. Wang, H. Kung, C. Ronsin, R. Breathnach, E. Leonard, and T. Kamata Macrophage stimulating protein activates Ras by both activation and translocation of Sos nucleotide exchange factor Biochem. Biophys. Res. Commun. 216 1995 110 118
39. C. Linington, S. Izumo, M. Suzuki, K. Uyemura, R. Meyermann, and H. Wekerle A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo J. Immunol. 133 1984 1946 1950
40. D.R. Lowy Function and regulation of Ras Annu. Rev. Biochem. 62 1993 851 891
41. D. Marciano, G. Ben-Baruch, M. Marom, Y. Egozi, R. Haklai, and Y. Kloog Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth J. Med. Chem. 38 1995 1267 1272
42. R.D. Marco, M. Khademi, E. Wallstrom, S. Muhallab, F. Nicoletti, and T. Olsson Amelioration of experimental allergic neuritis by sodium fusidate (fusidin): suppression of IFN gamma and TNF alpha and enhancement of IL-10 J. Autoimmun. 13 1999 187 195
43. M. Marom, R. Haklai, G. Ben-Baruch, D. Marciano, Y. Egozi, and Y. Kloog Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid J. Biol. Chem. 270 1995 22263 22270
44. F. Miyagi, H. Horiuchi, I. Nagata, S. Kitahara, M. Kiyoki, K. Komoriya, and N. Yuki Fc portion of intravenous immunoglobulin suppresses the induction of experimental allergic neuritis J. Neuroimmunol. 78 1997 127 131
45. H. Niv, O. Gutman, Y.I. Henis, and Y. Kloog Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies J. Biol. Chem. 274 1999 1606 1613
46. L. Notterpek, and R. Tolwani Experimental models of peripheral neuropathies Lab. Anim. Sci. 49 1999 588 599
47. G.J. Parry Guillain-Barré Syndrome 1993 Thieme Medical Publishers New York
48. M.I. Pastor, K. Reif, and D. Cantrell The regulation and function of p21ras during T-cell activation and growth Immunol. Today 16 1995 159 164
49. A. Rostami, M.J. Brown, R.P. Lisak, A.J. Sumner, B. Zweiman, and D.E. Pleasure The role of myelin P2 protein in the production of experimental allergic neuritis Ann. Neurol. 16 1984 680 685
50. H. Shin, E. McFarlane, J. Pollard, and E. Watson Induction of experimental allergic neuritis with synthetic peptides from myelin P2 protein Neurosci. Lett. 102 1989 309 312
51. D. Soffer, S. Feldman, and M. Alter Epidemiology of Guillain-Barré syndrome Neurology 28 1978 686 690
52. Y. Tanka Integrin activation by chemokines: relevance to inflammatory adhesion cascade during T cell migration Histol. Histopathol. 15 2000 1169 1176
53. F.G. van der Meche, and P.I. Shmitz A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain-Barré syndrome. Dutch Guillain-Barré Study Group N. Engl. J. Med. 326 1992 1123 1129
54. N. Waksman, and R. Adams Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvant J. Exp. Med. 102 1955 213 225
55. H. Wietholter, P. Hulser, C. Linington, D. Meier, and K. Wessel Electrophysiological follow up of experimental allergic neuritis mediated by permanent T cell line in rats J. Neurol. Sci. 83 1988 1 14
56. M. Woodrow, S. Rayter, J. Downward, and D. Cantrell p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells J. Immunol. 150 1993 3853 3861
57. J. Zhu, E. Mix, and H. Link Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barré syndrome J. Neuroimmunol. 84 1998 40 52
58. J. Zhu, X. Bai, G. Hedlund, J. Bjork, M. Bakhiet, P.V.D. Meide, and H. Link Linomide suppresses experimental autoimmune neuritis in Lewis rats by inhibiting myelin antigen-reactive T and B cell responses Clin. Exp. Immunol. 115 1999 56 63
59. L. Zou, J. Zhu, G. Deng, M. Levi, B. Wahren, A. Diab, J. Hillert, and H. Link Treatment with P2 protein peptide 57-81 by nasal route is effective in Lewis rat experimental autoimmune neuritis J. Neuroimmunol. 85 1998 137 145
60. L. Zou, D. Ma, L. Wei, P.V.D. Meide, E. Mix, and J. Zhu IFN beta suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue J. Neurosci. Res. 56 1999 123 130