IFN-β suppresses experimental autoimmune neuritis in Lewis rats by inhibiting the migration of inflammatory cells into peripheral nervous tissue

Journal of Neuroscience Research

Volumn 56, Issue 2, 1999, Pages 123-130

  Zou, Li Ping ^a   Ma, Di Hui ^a   Wei, Lei ^a   Van Der Meide, Peter H ^b   Mix, Eilhard ^c   Zhu, Jie ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Experimental autoimmune neuritis; IFN ; Immunotherapy; Migration

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; RECOMBINANT BETA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GUILLAIN BARRE SYNDROME; IMMUNIZATION; INFLAMMATORY CELL; NEURITIS; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL MIGRATION INHIBITION; CHEMOKINE CCL2; FEMALE; INTERFERON TYPE II; INTERFERON-BETA; MACROPHAGES; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; RATS; RATS, INBRED LEW; SCIATIC NERVE; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033135271     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990415)56:2<123::AID-JNR2>3.0.CO;2-G     Document Type: Article

References (31)

1. Andersson M, Khademi M, Wallström E, Olsson T. 1997. Cytokine profile in interferon-β treated multiple sclerosis patients: reduction of interleukin-10 mRNA expressing cells in peripheral blood. Eur J Neurol 4:567-7571.
2. Arnason BG, Toscas A, Dayal A, Qu Z, Noronha A. 1997. Role of interferons in demyelinating. J Neural Transm Suppl 49:117-123.
3. Calabresi PA, Tranquill LR, McFarland HF, Cowan EP. 1998. Cytokine gene expression in cells derived from CSF of multiple sclerosis patients. J Neuroimmunol 89:198-205.
4. Creange A, Lerat H, Meyrignac C, Degos JD, Gherardi RK, Cesaro P. 1998. Treatment of Guillain-Barré syndrome with interferon-β. Lancet 352:368-368.
5. De Luca G, Lugaresi A, Iarlori C, Marzoli F, Uncini A, Gambi D. 1998. Interferon beta normalizes suppressor cell function in dysimmune neuropathies. J Neuroimmunol 82:1-4.
6. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. 1985. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316:701-705.
7. Dijkema R, van der Meide PH, Dubbleld M, Caspers M, Wubben J, Schellekens H. 1986. Cloning, expression and purification of rat IFN-γ Methods Enzymol 119:453-464.
8. Hartung HP, Schäfer B, van der Meide PH, Fierz W, Heininger K, Toyka KV. 1990. The role of interferon-gamma in the pathogenesis of experimental autoimmune disease of the peripheral nervous system. Ann Neurol 27:247-256.
9. Hartung HP. 1995. Pathogenesis of inflammatory demyelination: implications for therapy. Curr Opin Neurol 8:191-199.
10. Jung S, Schluesener HJ, Schmidt B, Fontana A, Toyka KV, Hartung HP. 1994. Therapeutic effect of transforming growth factor-β2 on actively induced EAN but not adoptive transfer EAN. Immunology 83:545-551.
11. Kadlubowski M, Hughes RA. 1979. Identification of the neuritogen for experimental allergic neuritis. Nature 277:140-141.
12. Karpus WJ, Kennedy KJ. 1997. MIP-1 alpha and MCP-I differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J Leukoc Biol 62:681-689.
13. McDonald WI, Miller DH, Thompson AJ. 1994. Are magnetic resonance findings predictive of clinical outcome in therapeutic trials in multiple sclerosis? The dilemma of interferon-beta. Ann Neurol 36:62-67.
14. Milner P, Lovelidge CA, Taylor WA, Hughes RA. 1987. PO myelin protein produces experimental allergic neuritis in Lewis rats. J Neurol Sci 79:275-285.
15. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248:1230-1234.
16. Noronha A, Toscas A, Jensen MA. 1993. Interferon beta decreases T cell activation and interferon gamma production in multiple sclerosis. J Neuroimmunol 46:145-154.
17. Norton WI, Poduslo SE. 1973. Myelination in rat nerve: method of myelin isolation. J Neurochem 21:749-757.
18. Olsson T, Kelic S, Edlund C, Bakhiet M, Höjeberg B, Van der Meide PH, Ljungdahl Å, Kristensson K. 1994. Neuronal interferon-γ immunoreactive molecule: Bioactivities and purification. Eur J Immunol 24:308-314.
19. Panitch HS. 1992. Interferons in multiple sclerosis. A review of the evidence. Drugs 44:946-62.
20. Rep MH, Hintzen RQ, Polman CH, van Lier RA. 1996. Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. J Neuroimmunol 67:111-118.
21. Rudick RA, Ransohoff RM, Peppler R, VanderBrug Medendorp S, Lehmann P, Alam J. 1996. Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann Neurol 40:618-627.
22. Ruuls SR, de Labie MCDC, Weber KS, Botman CAD, Groenestein RJ, Dijkstra CD, Olsson T, van der Meide PH. 1996. The length of treatment determines whether IFN-β prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats. J Immunol 157:5721-31.
23. Shirai T, Shimizu N, Horiguchi S, Ito H. 1989. Rat TNF alpha. Agric Biol Chem 53:1733-1736.
24. Stuve O, Dooley NP, Uhm JH, Antel JP, Francis GS, Williams G, Yong WV. 1996. Interferon β-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9. Ann Neurol 40:853-863.
25. Stuve O, Chabot S, Jung SS, Williams G, Yong VW. 1997. Chemokine-enhanced migration of human peripheral blood mononuclear cells is antogonizaed by interferon beta-1b through an effect on matrix metalloproteinase-9. J Neuroimmunol 80:38-46.
26. van der Meide PH, de Labie MC, Ruuls SR, Groenestein RJ, Botman CA, Olsson T, Dijkstra CD. 1998. Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms. J Neuroimmunol 84:14-23.
27. Wahl S, McCartney-Francis N, Mergenhagen SE. 1989. Inflammatory and immunomodulatory roles of TGF-β. Immunol Today 10: 258-261.
28. Waksman NH, Adams RD. 1955. Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvant. J Exp Med 102:213-225.
29. Yong VW, Chabot S, Stuve O, Williams G. 1998. Interferon beta in the treatment of multiple sclerosis: mechanisms of action. Neurology 51:682-689.
30. Yu M, Nishiyama A, Trapp BD, Tuohy VK. 1996. Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol 64:91-100.
31. Zhu J, Mix E, Olsson T, Link H. 1994. Cellular mRNA expression of interferon-γ interleukin 4 and transforming growth factor-β by rat mononuclear cells stimulated with peripheral nerve antigens in experimental allergic neuritis. Clin Exp Immunol 98:306-312.