In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat

Toxicology

Volumn 214, Issue 1-2, 2005, Pages 113-122

  Souidi, M ^a   Gueguen, Y ^a   Linard, C ^a   Dudoignon, N ^a   Grison, S ^a   Baudelin, C ^a   Marquette, C ^a   Gourmelon, P ^a   Aigueperse, J ^a   Dublineau, I ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

CAR; CYP3A; Depleted uranium; PXR

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DRINKING WATER; DRUG METABOLIZING ENZYME; MESSENGER RNA; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; URANIUM;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; CONTAMINATION; CONTROLLED STUDY; ENZYME ACTIVATION; EVALUATION; IN VIVO STUDY; INGESTION; KIDNEY; LIVER; LIVER LEVEL; LIVER TOXICITY; LONG TERM EXPOSURE; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; MALE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; URANIUM COMPOUNDS;

EID: 25644446204     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.06.006     Document Type: Article

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