Balancing the ethanol formation in continuous bioreactors with ethanol stripping

Engineering in Life Sciences

Volumn 5, Issue 4, 2005, Pages 325-332

  Löser, Christian ^a   Schroder A ^a   Deponte, S ^a   Bley, T ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; BIOSYNTHESIS; BIOTECHNOLOGY; COMPUTER SIMULATION; EVAPORATION; FLOW OF FLUIDS; MASS TRANSFER; MATHEMATICAL MODELS; PHASE TRANSITIONS;

CONTINUOUS BIOREACTORS; ETHANOL FORMATION; ETHANOL STRIPPING; METABOLIC FLUX ANALYSIS; WATER LOSSES;

ETHANOL;

ALCOHOL;

ETHANOL;

ARTICLE; BIOREACTOR; CALCULATION; CHEMICAL INTERACTION; CHEMICAL PROCEDURES; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; MATHEMATICAL COMPUTING; PARTITION COEFFICIENT; PHASE TRANSITION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TEMPERATURE DEPENDENCE;

EID: 25444516267     PISSN: 16180240     EISSN: None     Source Type: Journal    
DOI: 10.1002/elsc.200520084     Document Type: Article

References (28)

1. J.M. Dominguez, N. Cao, C.S. Gong, G.T. Tsao, Ethanol production from xylose with the yeast Pichia stipitis and simultaneous product recovery by gas stripping using a gas-lift loop fermentor with attached side-arm (GLSA), Biotechnol. Bioeng. 2000, 67, 336-343.
2. F. Taylor, M.J. Kurantz, N. Goldberg, J.C. Craig Jr. Continuous fermentation and stripping of ethanol, Biotechnol. Prog. 1995, 11, 693-698.
3. F. Taylor, M. J. Kurantz, N. Goldberg, J. C. Craig Jr., Effects of ethanol concentration and stripping temperature on continuous fermentation rate, Appl. Microbiol. Biotechnol. 1997, 48, 311-316.
4. F. Taylor, M. J. Kurantz, N. Goldberg, J. C. Craig Jr., Kinetics of continuous fermentation and stripping of ethanol, Biotechnol. Lett. 1998, 20, 67-72.
5. F. Taylor, M. J. Kurantz, N. Goldberg, A. J. McAloon, J. C. Craig Jr., Dry-grind process for fuel ethanol by continuous fermentation and stripping, Biotechnol. Prog. 2000, 16, 541-547.
6. P. Duboc, U. von Stockar, Systematic errors in data evaluation due to ethanol stripping and water vaporization, Biotechnol. Bioeng. 1998, 58, 428-439.
7. U. Schulze, Anaerobic physiology of Saccharomyces cerevisiae, Ph. D. Thesis, Technical University of Denmark, Lyngby (Denmark) 1995.
8. T. L. Nissen, U. Schulze, J. Nielsen, J. Villadsen, Flux distribution in anaerobic, glucose-limited continuous cultures of Saccharomyces cerevisiae, Microbiol. 1997, 143, 203-218.
9. P. Daran-Lapujade, M. L. A. Jansen, J. M. Daran, W. van Gulik, J. H. de Winde, J. T. Pronk, Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae; a chemostat culture study, J. Biol. Chem. 2004, 279, 9125-9138.
10. C.J. Franzén, Metabolic flux analysis of RQ-controlled microaerobic ethanol production by Saccharomyces cerevisiae, Yeast 2003, 20, 117-132.
11. R. Gonzalez, B. A. Andrews, J. Molitor, J. A. Asenjo, Metabolic analysis of the synthesis of high levels of intracellular human SOD in Saccharomyces cerevisiae rhSOD 2060 411 SGA122, Biotechnol. Bioeng. 2003, 82, 152-169.
12. T. B. Granström, A. A. Aristidou, J. Jokela, M. Leisola, Growth characteristics and metabolic flux analysis of Candida milleri, Biotechnol. Bioeng. 2000, 70, 197-207.
13. T. Granström, A. A. Aristidou, M. Leisola, Metabolic flux analysis of Candida tropicalis growing on xylose in an oxygen-limited chemostat, Metab. Eng. 2002, 4, 248-256.
14. J. P. Pitkänen, A. Aristidou, L. Salusjärvi, L. Ruohonen, M. Penttilä, Metabolic flux analysis of xylose metabolism in recombinant Saccharomyces cerevisiae using continuous culture, Metab. Eng. 2003, 5, 16-31.
15. I. Särväri Horväth, C. J. Franzén, M. J. Taherzadeh, C. Niklasson, G. Lidén, Effects of furfural on the respiratory metabolism of Saccharomyces cerevisiae in glucose-limited chemostats, Appl. Environ. Microbiol. 2003, 69, 4076-4086.
16. M. Sonderegger, M. Jeppsson, B. Hahn-Hägerdal, U. Sauer, Molecular basis for anaerobic growth of Saccharomyces cerevisiae on xylose, investigated by global gene expression and metabolic flux analysis, Appl. Environ. Microbiol. 2004, 70, 2307-2317.
17. C. F. Wahlbom, B. Hahn-Hägerdal, Furfural, 5-hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae, Biotechnol. Bioeng. 2002, 78, 172-178.
18. C. F. Wahlbom, A. Eliasson, B. Hahn-Hägerdal, Intracellular fluxes in a recombinant xylose-utilizing Saccharomyces cerevisiae cultivated anaerobically at different dilution rates and feed concentrations, Biotechnol. Bioeng. 2001, 72, 289-296.
19. A. Sheoran, B. S. Yadav, P. Nigam, D. Singh, Continuous ethanol production from sugarcane molasses using a column reactor of immobilized Saccharomyces cerevisiae HAU-1, J. Basic Microbiol. 1998, 38, 123-128.
20. H. Jeppsson, S. Yu, B. Hahn-Hägerdal, Xylulose and glucose fermentation by Saccharomyces cerevisiae in chemostat culture, Appl. Environ. Microbiol. 1996, 62, 1705-1709.
21. C. Larsson, U. von Stockar, I. Marison, L. Gustafsson, Growth and metabolism of Saccharomyces cerevisiae in chemostat cultures under carbon-, nitrogen-, or carbon- and nitrogen-limiting conditions, J. Bacteriol. 1993, 175, 4809-4816.
22. J. Thierie, Modeling threshold phenomena, metabolic pathways switches and signals in chemostat-cultivated cells: the Crabtree effect in Saccharomyces cerevisiae, J. Theor. Biol. 2004, 226, 483-501.
23. F. Lei, L. Olsson, S. B. Jørgensen, Dynamic effects related to steady-state multiplicity in continuous Saccharomyces cerevisiae cultivations, Biotechnol. Bioeng. 2004, 88, 838-848.
24. Landolt-Börnstein, in Eigenschaften der Materie in ihren Aggregatzus-tänden, Part 5a: Transportphänomene I, Springer, Berlin, Heidelberg, New York 1969.
25. J. Gmehling, U. Onken, in Vapor-Liquid Equilibrium Data Collection, Vol. 1, Dechema, Frankfurt/M. 1977.
26. J. Gmehling, U. Onken, W. Artl, in Vapor-Liquid Equilibrium Data Collection, Vol. 1a, Dechema, Frankfurt/M. 1981.
27. Landolt-Börnstein, in Eigenschaften der Materie in ihren Aggregatzusus-tänden, Part 2a: Gleichgewichte Dampf-Kondensat und osmotische Phänomene, Springer, Berlin, Göttingen, Heidelberg 1960.
28. J. R. Rarey, J. Gmehling, Computer-operated differential static apparatus for the measurement of vapor-liquid equilibrium data, Fluid Phase Equilib. 1993, 83, 279-287.