Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility

Cancer Research

Volumn 65, Issue 19, 2005, Pages 8655-8661

  Prasad, Vikram ^a   Boivin, Gregory P ^a   Miller, Marian L ^a   Liu, Lynne H ^a   Erwin, Christopher R ^b   Warner, Brad W ^b   Shull, Gary E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); PROTEIN P53; SARCOENDOPLASMIC RETICULUM CALCIUM ATPASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ATP2A2 GENE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; DARIER DISEASE; FEMALE; FORESTOMACH; GENE; GENE MUTATION; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KERATINIZATION; KERATINOCYTE; MALE; MOUSE; NONHUMAN; ONCOGENE K RAS; PAPILLOMA; PRIORITY JOURNAL; PROTO ONCOGENE; SKIN DISEASE; SQUAMOUS CELL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; CALCIUM-TRANSPORTING ATPASES; CARCINOMA, SQUAMOUS CELL; GENES, P53; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KERATINOCYTES; KERATINS; LOSS OF HETEROZYGOSITY; MALE; MICE; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 25444503742     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-0026     Document Type: Article

References (46)

1. 2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem 1999;274:2556-62.
2. 2+-handling proteins. J Cell Biol 2003;160:475-9.
3. 2+ pumps revealed by analysis of null mutants. Ann N Y Acad Sci 2003;986:453-60.
4. 2+ signaling and control of growth and proliferation. Biol Cell 2004;96:55-68.
5. See V, Rajala NK, Spiller DG, White MR. Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-κB pathway in Swiss 3T3 cells. J Cell Biol 2004;166:661-72.
6. Papp B, Brouland J-P, Gelebart P, Kovacs T, Chomienne C. Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukemia cells. Biochem Biophys Res Commun 2004;322:1223-36.
7. Wu Y, Palad AJ, Wasilenko WJ, et al. Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole. Clin Cancer Res 1997;11:1915-21.
8. 2+ pump, cause Darier disease. Nat Genet 1999;21:271-7.
9. 2+ pump. J Biol Chem 2001;276:26737-40.
10. Hakii H, Fujiki H, Suganuma M, et al. Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis. J Cancer Res Clin Oncol 1986;111:177-81.
11. Gniadecki R, Gajkowska B. Intracellular calcium pool emptying induces DNA synthesis in HaCaT keratinocytes. Exp Dermatol 2003;12:453-9.
12. Harmon CS, Ducote J, Xiong Y. Thapsigargin induces rapid, transient growth inhibition and c-fos expression followed by sustained growth stimulation in mouse keratinocyte cultures. J Invest Dermatol 1996;107:188-94.
13. Barbacid M. ras genes. Annu Rev Biochem 1987;56:779-827.
14. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
15. Kaneko M, Morimura K, Nishikawa T, et al. Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis 2002;23:1729-35.
16. Kroes R, Wester PW. Forestomach carcinogens: possible mechanisms of action. Food Chem Toxicol 1986;24:1083-9.
17. Green DR, Evan GI. A matter of life and death. Cancer Cell 2002;1:19-30.
18. Chandrasekera CP, Lytton J. Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction. J Biol Chem 2003;278:12482-8.
19. Cavenee WK, Hansen MF, Nordenskjold M, et al. Genetic origin of mutations predisposing to retinoblastoma. Science 1985;228:501-3.
20. Wijnhoven SWP, Kool HJM, van Teijlingen CMM, van Zeeland AA, Vrieling H. Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation? Mutat Res 2001;473:23-36.
21. Huang Y, Anderle P, Bussey KJ, et al. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 2004;64:4294-301.
22. Sontheimer H. Ion channels and amino acid transporters support the growth and invasion of primary brain tumors. Mol Neurobiol 2004;29:61-71.
23. Haseman JK, Elwell MR, Hailey JR. Neoplasm incidences in B6C3F1 mice: NTP historical data. In: Maronpot RR, Boorman GA, Gaul BW, editors. Pathology of the mouse. Vienna, IL: Cache River Press;1999. p. 679-89.
24. 2+ ATPase type 2 downregulated in human oral squamous cell carcinoma. Int J Cancer 2004;110:225-31.
25. 2+-ATPases in thyroid and its down-regulation following neoplastic transformation. J Mol Endocrinol 2003;30:399-409.
26. Gelebart P, Kovacs T, Brouland J, et al. Expression of endomembrane calcium pumps in colon and gastric cancer cells. J Biol Chem 2002;29:26310-20.
27. 2+ spike frequency can optimize gene expression. Nature 1998;392:936-41.
28. Bachs O, Agell N, Carafoli E. Calcium and calmodulin function in the cell nucleus. Biochim Biophys Acta 1992;1113:259-70.
29. Gafter U, Malachi T, Ori Y, Breitbart H. The role of calcium in human lymphocyte DNA repair ability. J Lab Clin Med 1997;130:33-41.
30. 2+ pump. Arch Biochem Biophys 1996;329:65-72.
31. Twigg J, Patel R, Whitaker M. Translational control of InsP3-induced chromatin condensation during the early cell cycles of sea urchin embryos. Nature 1988;332:366-9.
32. Qu L, Huang S, Baltzis D, et al. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β. Genes Dev 2004;18:261-77.
33. Freedberg IM, Tomic-Canic M, Komine M, Blumenberg M. Keratins and the keratinocyte activation cycle. J Invest Dermatol 2001;116:633-40.
34. Dolci M, Favia G, Scully C, Di Alberti L. Keratosis follicularis of the oral mucosa with oral squamous cell carcinoma. Oral Oncol 2004;40:856-8.
35. Vaquez J, Morales C, Gonzalez LO, Lamelas ML, Ribas A. Vulval squamous cell carcinoma arising in localized Darier's disease. Eur J Obstet Gynecol Reprod Biol 2002;102:206-8.
36. Downs AM, Ward KA, Peachey RD. Subungual squamous cell carcinoma in Darier's disease. Clin Exp Dermatol 1997;22:277-9.
37. Rangarajan A, Weinberg RA. Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer 2003;3:952-9.
38. Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. J Dermatol Sci 1998;17:1-7.
39. Hoa M, Davis SL, Ames SJ, Spanjaard RA. Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma. Cancer Res 2002;62:7154-6.
40. Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002;4:487-94.
41. 2+. FEBS Lett 2003;546:6-10.
42. Singh A, Sowjanya AP, Ramakrishna G. The wild-type Ras: road ahead. FASEB J 2005;19:161-9.
43. Dajee M, Tarutani M, Deng H, Cai T, Khavari PA. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002;21:1527-38.
44. Lin AW, Lowe SW. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A 2001;98:5025-30.
45. Ferbeyre G, de Stanchina E, Lin AW, et al. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 2002;22:3497-508.
46. Kim E, Deppert W. Transcriptional activities of mutant p53: when mutations are than a loss. J Cell Biochem 2004;93:878-86.