Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Granulomas as potential lymphoid tissue maintaining autoantibody production

Annals of the New York Academy of Sciences

Volumn 1051, Issue , 2005, Pages 12-19

  Voswinkel, Jan ^a   Muller A ^b   Lamprecht, P ^b  

^a Rheumaklinik Bad Bramstedt   (Germany)

^b NONE

Author keywords

B lymphocytes; Granuloma; Lymphoid tissue; T lymphocytes; Wegener's granulomatosis (WG)

Indexed keywords

AUTOANTIBODY; CD28 ANTIGEN; CD4 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ANCA ASSOCIATED VASCULITIS; ANTIBODY PRODUCTION; B LYMPHOCYTE; CELL MATURATION; CONFERENCE PAPER; DISEASE COURSE; DISEASE EXACERBATION; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; INFLAMMATION; LEUKOCYTE; LOWER RESPIRATORY TRACT; LYMPHOCYTE DIFFERENTIATION; LYMPHOID TISSUE; MACROPHAGE; MEMORY CELL; RISK FACTOR; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; TH1 CELL; UPPER RESPIRATORY TRACT; WEGENER GRANULOMATOSIS;

STAPHYLOCOCCUS AUREUS;

EID: 25444502877     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1361.042     Document Type: Conference Paper

References (50)

1. GEPHARDT, G.N., M. AHMAD & R.R. TUBBS. 1983. Pulmonary vasculitis (Wegener's granulomatosis): immunohistochemical study of T and B cell markers. Am. J. Med. 74: 700-704.
2. SCHMITT, W.H., C. HEESEN, E. CSERNOK, et al. 1992. Elevated serum levels of soluble interleukin-2 recepetor in patients with Wegener's granulomatosis: association with disease activity. Arthritis Rheum. 35: 1088-1096.
3. STEGEMAN, C.A., J.W. COHEN-TERVAERT, M.G. HUITEMA, et al. 1993. Serum markers of T cell activation in relapses of Wegener's granulomatosis. Clin. Exp. Immunol. 91: 415-420.
4. POPA, E.R., C.A. STEGEMAN, N.A. BOS, et al. 1999. Differential B and T cell activation in Wegener's granulomatosis. J. Allergy Clin. Immunol. 103: 885-894.
5. CHRISTENSSON, M., E. PETTERSSON, K.G. SUNDQVIST, et al. 2000. T cell activation in patients with ANCA-associated vasculitis: inefficient immune suppression by therapy. Clin. Nephrol. 54: 435-442.
6. VOGT, S., C. IKING-KONERT, F. HUG, et al. 2003. Shortening of telomeres: evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis. Kidney Int. 63: 2144-2151.
7. GISCOMBE, R., J. GRUNEWALD, S. NITYANAND, et al. 1995. T cell receptor (TCR) V gene usage in patients with systemic necrotizing vasculitis. Clin. Exp. Immunol. 101: 213-219.
8. BROUWER, E., J.W. COHEN-TERVAERT, G. HORST, et al. 1991. Predominance of IgG1 and IgG4 subclasses of antineutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosi and clinically related disorders. Clin. Exp. Immunol. 83: 379-386.
9. BALLIEUX, B.E., S.H. VAN DER BURG, E.C. HAGEN, et al. 1995. Cell-mediated autoimmunity in patients with Wegener's granulomatosis (WG). Clin. Exp. Immunol. 100: 186-193.
10. LOCKWOOD, C.M., S. THIRU, J.D. ISAACS, et al. 1993. Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. Lancet 341: 1620-1622.
11. SCHMITT, W.H., B.C. HAGEN, I. NEUMANN, et al. 2004. Treatment of refractory Wegener's granulomatosis with antithymocyte globulin (ATG): an open study in 15 patients. Kidney Int. 65: 1440-1448.
12. KEOGH, K.A., M.E. WYLAM, J.H. STONE, et al. 2005. Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 52: 262-268.
13. + T cells from a memory to memory/effector phenotype. J. Immunol. 168: 5538-5550.
14. APPAY, V. 2004. The physiological role of cytotoxic CD4(+) T cells: the holy grail. Clin. Exp. Immunol. 138: 10-13.
15. + T cell subsets in Wegener's granulomatosis. Rheumatol. Int. 14: 213-219.
16. GISCOMBE, R., S. NITYANAND, N. LEWIN, et al. 1998. Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlates with disease activity. J. Clin. Immunol. 18: 404-413.
17. MOOSIG, F., E. CSERNOK, G. WANG, et al. 1998. Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin. Exp. Immunol. 114: 113-118.
18. LAMPRECHT, P., F. MOOSIG, E. CSERNOK, et al. 2001. CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax 56: 751-757.
19. - T cells are a major source of IFN-γ and TNF-α in Wegerner's granulomatosis. Am. J. Pathol. 160: 1717-1724.
20. - T cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clin. Immunol. 108: 1-7.
21. + T cell populations in Wegener's granulomatosis. Cell Immunol. 2003 224:1-7.
22. VALLEJO, A.N., C.M. WEYAND & J.J. GORONZY. 2004. T cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol. Med. 10: 119-124.
23. TAKAGI, D., K. IWABUCHI, C. IWABUCHI, et al. 2004. Immunoregulatory defects of V alpha 24V+ beta 11+ NKT cells in development of Wegener's granulomatosis and relapsing polychondritis. Clin. Exp. Immunol. 136: 591-600.
24. LUDVIKSSON, B.R., M.C. SNELLER, K.S. CHUA, et al. 1998. Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10. J. Immunol. 160: 3602-3609.
25. CSERNOK, E., A. TRABANDT, A. MULLER, et al. 1999. Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis Rheum. 42: 742-570.
26. MULLER, A., A. TRABANDT, K. GLOECKNER-HOFMANN, et al. 2000. Localized Wegener's granulomatosis: predominance of CD26 and IFN-gamma expression. J. Pathol. 192: 113-120.
27. SNELLER, M.C. 2002. Granuloma formation, implications for pathogenesis of vasculitis. Cleveland Clin. J. Med. 69: SII40-43.
28. LAMPRECHT, P., A. ERDMANN, A. MULLER, et al. 2003. Heterogeneity of CD4+ and CD8+ memory T cells in localized and generalized Wegener's granulomatosis. Arthritis Res. Ther. 5: R25-31.
29. COULOMB-L'HERMINE, A., F. CAPRON, W. ZOU, et al. 2001. Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis. Hum. Pathol. 32: 320-326.
30. REINHOLD-KELLER, E., P. LAMPRECHT, A.C. FELLER & W.L. GROSS. 2001. Polyarthritis following interferon alpha treatment in a patient with localized Wegener's granulomatosis. Clin. Exp. Rheumatol. 19: 227-228.
31. SANDERS, J.S., C.A. STEGEMAN & C.G. KALLENBERG. 2003. The Th1 and Th2 paradigm in ANCA-associated vasculitis. Kidney Blood Press Res. 26: 215-220.
32. GRIFFITH, M.E., A. COULTHARD & C.D. PUSEY. 1996. T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis. Clin. Exp. Immunol. 103: 253-258.
33. MATHIESON, P.W., C.M. LOCKWOOD & D.B. OLIVEIRA. 1992. T and B cell responses to neutrophil cytoplasmic antigens in systemic vasculitis. Clin. Immunol. Immunopathol. 63: 135-141.
34. RASMUSSEN N & J. PETERSEN. 1993. Cellular immune responses and pathogenesis in C-ANCA positive vasculitides. J. Autoimmun. 6: 227-236.
35. BROUWER, E., C.A. STEGEMAN, M.G. HUITEMA, et al. 1994. T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG). Clin. Exp. Immunol. 98: 448-453.
36. KING, W.J., C.J. BROOKS, R. HOLDER, et al. 1998. T lymphocyte responses to antineutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission. Clin. Exp. Immunol. 112: 539-546.
37. VAN DER GELD, Y.M., M.G. HUITEMA, C.F. FRANSSEN, et al. 2000. In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG). Clin. Exp. Immunol. 122: 504-513.
38. POPA, E.R., C.F. FRANSSEN, P.C. LIMBURG, et al. 2002. In vitro cytokine production and proliferation of T cells from patients with antiproteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase. Arthritis Rheum. 46: 1894-1904.
39. WINEK, J., A. MUELLER, E. CSERNOK, et al. 2004. Frequency of proteinase 3 (PRS)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosis. J. Autoimmun. 22: 79-85.
40. + T lymphocytes in response to Staphylococcus aureus in patients with Wegener's granulomatosis. Scand. J. Immunol. 49: 585-594.
41. ASSENMACHER, M., M. LÖHNING, A. SCHEFFOLD, et al. 1998. Sequential production of IL-2, IFN-γ, and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes. Eur. J. Immunol. 28: 1534-1543.
42. CLAYTON, A.R. & C.O. SAVAGE. 2003. Production of antineutrophil cytoplasm antibodies derived from circulating B cells in patients with systemic vasculitis. Clin. Exp. Immunol. 132: 174-179.
43. JANEWAY, C.A., JR. 2001. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. USA 98: 7461-7468.
44. ZINKERNAGEL, R.M. & H. HENGARTNER. 1999. Regulation of the immune response by antigen. Science 293: 251-253.
45. VOSWINKEL, J., A. MULLER, P. LAMPRECHT, et al. 2002. Does ANCA formation result from an antigen-triggered immune response in Wegener's endonasal inflamed tissue? Cleveland Clin. J. Med. 69(suppl. 2): SII-159.
46. BRAUN, M.G., E. CSERNOK, W.L. GROSS, et al. 1991, Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis: immunolocalization in normal and pathologic tissues, Am. J. Pathol. 139: 831-838.
47. POPA, E.R., C.A. STEGEMAN, C.G.M. KALLENBERG, et al. 2002. Staphylococcus aureus and Wegener's granulomatosis. Arthritis Res, 4: 77-79.
48. VOSWINKEL, J., J. KRAEMER, A, MUELLER, et al. 2004. B lymphocytes infiltrating Wegener's granuloma: the immunoglobulin VH gene repertoire from granulomatous tissues displays an antigen-driven maturation and suggests a microbial trigger. Arthritis Res, 6: S24.
49. MOOSIG, F., E. CSERNOK, G. KUMANOVICS, et al. 2000. Opsonization of apoptotic neutrophils by antineutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumor necrosis factor-alpha (TNF-α). Clin. Exp. Immunol. 122: 499-503.
50. EHLERS, S., J. BENINI, H.D. HELD, et al. 2001. αβ TCR+ cells and IFNγ, but not iNOS, are critical for granuloma necrosis in a mouse model for mycobacteria-induced pulmonary immunopathology. J. Exp. Med. 194: 1847-1859.