T cell activation in patients with ANCA-associated vasculitis: Inefficient immune suppression by therapy

Clinical Nephrology

Volumn 54, Issue 6, 2000, Pages 435-442

  Christensson, M ^a   Pettersson, E ^a   Sundqvist, K G ^a   Christensson, B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ANCA; T cells; Vasculitis; Wegener

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADULT; AGED; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; MALE; MEMORY CELL; RELAPSE; REMISSION; SYSTEMIC VASCULITIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; WEGENER GRANULOMATOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIGENS, CD; ANTIGENS, CD27; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; RECURRENCE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TREATMENT FAILURE; VASCULITIS;

EID: 0033668603     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. The role of CD28 co-stimulation in the generation of cytotoxic T cells
2. Cell-mediated autoimmunity in patients with Wegener's granulomatosis (WG)
3. T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis
4. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling
5. Interleukin-2 production in plasma, urine and plasma interleukin-2 receptor levels and urine cytology as a means of monitoring renal allograft recipients
6. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member
7. CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLA-DR+ CD38-CD8+ cells is associated with subsequent stable CD4+ cells. The Multicenter AIDS Cohort Study Group
8. T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis
9. Increased expression of CD25 and adhesion molecules on peripheral blood lymphocytes of patients with Wegener's granulomatosis (WG) and ANCA-positive vasculitides
10. Development and standardization of solid phase assays for the detection of anti-neutrophil cytoplasmic antibodies (ANCA). A report on the second phase of an international cooperative study on the standardization of ANCA assays
11. Compassionate treatment of Wegener's granulomatosis with rabbit anti-thymocyte globulin
12. Phenotypic and functional separation of memory and effector human CD8+ T cells
13. Distinctive increases in HLA-DR+ and CD8+57+ lymphocyte subsets in Wegener's granulomatosis
14. Nomenclature of systemic vasculitides: Proposal of an international consensus conference
15. T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission
16. Elevated concentrations of soluble interleukin-2 receptors in serum samples and bronchoalveolar fluids in active sarcoidosis
17. Refractory Wegener's granulomatosis: A model for shorter immunotherapy of autoimmune diseases
18. Birmingham vasculitis activity score (BVAS) in systemic necrotizing vasculitis
19. Age-related changes of neuro-endocrine immune interactions in healthy humans
20. Human CD38 a cell-surface protein with multiple functions
21. Shortened telomeres in clonally expanded CD28- CD8+ T cells imply a replication history that is distinct from their CD28+ CD8+ counterparts
22. Co-stimulatory molecules in Wegener's granulomatosis (WG): Lack of expression of CD28 and preferential upregulation of its ligands B7-B1 (CD80) and B7-2 (CD86) on T cells
23. T cell activation in Crohn's disease: Increased levels of soluble interleukin-2 receptor in serum and supernatants of stimulated peripheral blood mononuclear cells
24. Serum levels of soluble interleukin-2 receptor are dependent on the kidney function
25. Antineutrophil cytoplasmic antibody (cANCA and pANCA) titers in relation to disease activity in patients with necrotizing vasculitis: A longitudinal study
26. Serial levels of soluble interleukin-2 receptor in the peripheral blood of patients with rheumatoid arthritis: Correlation with disease activity
27. Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener's granulomatosis. Association with disease activity
28. Activated CD4+ and CD8+ T cell subsets in Wegener's granulomatosis
29. Serum markers of T cell activation in relapses of Wegener's granulomatosis
30. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker disease activity in Wegener's granulomatosis
31. Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects