Stereoselective syntheses of highly functionalized bicyclo[3.1.0]hexanes: A general methodology for the synthesis of potent and selective mGluR2/3 agonists

Journal of Organic Chemistry

Volumn 70, Issue 20, 2005, Pages 8027-8034

  Tan, Lushi ^a   Yasuda, Nobuyoshi ^a   Yoshikawa, Naoki ^a   Hartner, Frederick W ^a   Eng, Kan Kaung ^a   Leonard, William R ^a   Tsay, Fuh Rong ^a   Volante, Ralph P ^a   Tillyer, Richard D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CYCLOPROPANATION; INTRAMOLECULAR EPOXIDE OPENING;

AROMATIC COMPOUNDS;

BICYCLO COMPOUND; EPOXIDE; HEXANE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST;

ARTICLE; CYCLOPROPANATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; QUANTUM YIELD; REACTION ANALYSIS; RING OPENING; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

BICYCLO COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEXANES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM;

EID: 25444486184     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0511187     Document Type: Article

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