Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: Safety, immunogenicity, and efficacy

Infection and Immunity

Volumn 72, Issue 6, 2004, Pages 3252-3259

  Rossi, Giacomo ^a   Ruggiero, Paolo ^b   Peppoloni, Samuele ^b,d   Pancotto, Laura ^b   Fortuna, Damiano ^c   Lauretti, Laura ^b   Volini, Gianfranco ^b   Mancianti, Silvia ^b   Corazza, Michele ^c   Taccini, Ennio ^c   Di Pisa, Francesco ^b   Rappuoli, Rino ^b   Del Giudice, Giuseppe ^b  

^a UNIVERSITY OF CAMERINO   (Italy)

^b CHIRON VACCINES   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; BACTERIAL TOXIN; CAGA PROTEIN; IMMUNOGLOBULIN G; PROTEIN NAP; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; DISEASE MODEL; DOG; DRUG EFFICACY; DRUG SAFETY; GASTRITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; DISEASE MODELS, ANIMAL; DOGS; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; RECOMBINANT PROTEINS; TREATMENT OUTCOME; VACCINATION;

EID: 2542573391     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.6.3252-3259.2004     Document Type: Article

References (39)

1. Covacci, A., S. Censini, M. Bugnoli, R. Petracca, D. Burroni, G. Macchia, A. Massone, E. Papini, Z. Xiang, N. Figura, and R. Rappuoli. 1993. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA 90:5791-5795.
2. Del Giudice, G., A. Covacci, J. L. Telford, C. Montecucco, and R. Rappuoli. 2001. The design of vaccines against Helicobacter pylori and their development. Annu. Rev. Immunol. 19:523-563.
3. Dixon, M. F., R. M. Genta, J. F. Yardley, and P. Correa. 1996. Classification and grading of gastritis: the updated Sydney system. Am. J. Surg. Pathol. 20:1161-1181.
4. Du, M. Q., and P. G. Isaccson. 2002. Gastric MALT lymphoma: from etiology to treatment. Lancet Oncol. 3:97-104.
5. Dubois, A., C. K. Lee, H. Kleanthous, P. T. Mehlman, and T. Monath. 1998. Immunization against natural Helicobacter pylori infection in nonhuman primates. Infect. Immun. 66:4340-4346.
6. Eisenberg, J. C., S. J. Czinn, C. A. Garhart, R. W. Redline, W. C. Bartholomae, J. M. Gottwein, J. G. Nedrud, S. E. Emancipator, B. B. Boehm, P. V. Lehmann, and T. G. Blanchard. 2003. Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infect. Immun. 71:1820-1827.
7. Ermak, T. H., P. J. Giannasca, R. Nichols, G. A. Meyers, J. Nedrud, and R. Weltzin. 1998. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J. Exp. Med. 188:2277-2288.
8. Ghiara, P., M. Rossi, M. Marchetti, A. Di Tommaso, C. Vindigni, F. Ciampolini, A. Covacci, J. L. Telford, M. T. De Magistris, M. Pizza, R. Rappuoli, and G. Del Giudice. 1997. Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection. Infect. Immun. 65:4996-5002.
9. Goodwin, C. S., J. A. Armstrong, and B. J. Marshall. 1986. Campylobacter pyloridis, gastritis, and peptic ulceration. J. Clin. Pathol. 39:353-365.
10. Gottwein, J. M., T. G. Blanchard, O. S. Targoni, J. C. Eisenberg, B. M. Zagorski, R. W. Redline, J. G. Nedrud, M. Tary-Lehmann, P. V. Lehmann, and S. J. Czinn. 2001. Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund adjuvant by systemic immunization. J. Infect. Dis. 184:308-314.
11. Guy, B., C. Hessler, S. Fourage, B. Robki, M. J. Quentin Millet. 1999. Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice. Vaccine 17:1130-1135.
12. Guy, B., C. Hessler, S. Fourage, J. Haensler, E. Vialon-Lafay, B. Rokbi, and M. J. Millet. 1998. Systemic immunization with urease protects mice against Helicobacter pylori infection. Vaccine 16:850-856.
13. Han, S. U., Y. B. Kim, H. J. Joo, K. B. Hahm, W. H. Lee, Y. K. Cho, D. Y. Kim, and M. W. Kim. 2002. Helicobacter pylori infection promotes gastric carcinogenesis in a mice model. J. Gastroenterol. Hepatol. 17:253-261.
14. Happonen, I., J. Linden, S. Saari, M. Karjalainen, M. L. Hanninen, K. Jalava, and E. Westmark. 1998. Detection and effects of helicobacters in healthy dogs and in dogs with signs of gastritis. J. Am. Vet. Med. Assoc. 213:1767-1774.
15. Kotloff, K. L., M. B. Sztein, S. S. Wasserman, G. A. Losonsky, S. C. Di Lorenzo, and R. I. Walker. 2001. Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection. Infect. Immun. 69:3581-3590.
16. Lee, C. K., K. Soike, J. Hill, K. Georgakopoulos, and T. Tibbitts. 1999. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys. Vaccine 17:1493-1505.
17. Lee, C. K. 2001. Vaccination against Helicobacter pylori in non-human primate models and humans. Scand. J. Immunol. 53:437-442.
18. Londoño-Arcilia, P., D. Freeman, H. Kleanthous, A. M. O'Dowd, S. Lewis, A. K. Turner, E. L. Rees, T. J. Tibbits, J. Greenwood, T. P. Monath, and M. J. Darsley. 2002. Attenuated Salmonella enterica serovar Typhi expressing urease effectively immunizes mice against Helicobacter pylori challenge as part of a heterologous mucosal priming-parental boosting vaccination regimen. Infect. Immun. 70:5096-5106.
19. Malfertbeiner, P., V. Schultze, G. Del Giudice, B. Rosenkranz, S. H. E. Kaufmann, F. Winau, T. Ulrichs, E. Theophil, C. P. Jue, D. Novicki, F. Norelli, M. Contorni, D. Berti, J. S. Lin, C. Schwenke, M. Goldman, D. Tornese, J. Ganju, E. Palla, R. Rappuoli, and B. Scharschmidt. 2002. Phase I safety and immunogenicity of a three-component H. pylori vaccine. Gastroenterology 122(Suppl. 1):A585.
20. Manetti, R., P. Massari, D. Burroni, M. De Bernard, A. Marchini, R. Olivieri, E. Papini, C. Montecucco, R. Rappuoli, and J. L. Telford. 1995. Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies. Infect. Immun. 63:4476-4480.
21. Marchetti, M., B. Aricò, D. Burroni, N. Figura, R. Rappuoli, and P. Ghiara. 1995. Development of a mouse model of H. pylori infection that mimics human disease. Science 267:1655-1658.
22. Marchetti, M., M. Rossi, V. Giannelli, M. M. Giuliani, M. Pizza, S. Censini, A. Covacci, P. Massari, C. Pagliaccia, R. Manetti, J. L. Telford, G. Douce, G. Dougan, R. Rappuoli, and P. Ghiara. 1998. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine 16:33-37.
23. Michetti, P., C. Kreiss, K. Kotloff, N. Porta, J. L. Blanco, D. Bachmann, M. Herranz, P. F. Saldinger, I. Corthésy-Theulaz, G. Losonsky, R. Nichols, J. Simon, M. Stolte, S. Ackerman, T. P. Monatb, and A. L. Blum. 1999. Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in H. pylori-infected adults. Gastroenterology 116:804-812.
24. Montecucco, C., and R. Rappuoli. 2001. Living dangerously: how Helicobacter pylori survives in the human stomach. Nat. Rev. Mol. Cell. Biol. 2:457-466.
25. Nedrud, J. G., S. S. Blanchard, and S. J. Czinn. 2002. Helicobacter pylori inflammation and immunity. Helicobacter 7(Suppl. 1):24-29.
26. Nedrud, J. G. 2001. Helicobacter pylori vaccines: lessons from small animal models. Scand. J. Immunol. 53:429-436.
27. Rappuoli, R. 1997. Rational design of vaccines. Nat. Med. 3:374-376.
28. Rossi, G., D. Fortuna, L. Pancotto, G. Renzoni, E. Taccini, P. Ghiara, R. Rappuoli, and G. Del Giudice. 2000. Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori. Infect. Immun. 68:4769-4772.
29. Rossi, G., M. Rossi, C. G. Vitali, D. Fortuna, D. Burroni, L. Pancotto, S. Capecchi, S. Sozzi, G. Renzoni, G. Braca, G. Del Giudice, R. Rappuoli, P. Ghiara, and E. Taccini. 1999. A conventional beagle dog model for acute and chronic infection with Helicobacter pylori. Infect. Immun. 67:3112-3120.
30. Ruggiero, P., S. Peppoloni, D. Berti, R. Rappuoli, and G. Del Giudice. 2002. New strategies for the prevention and treatment of Helicobacter pylori infection. Expert Opin. Investig. Drugs 11:1127-1138.
31. Ruggiero, P., S. Peppoloni, R. Rappuoli, and G. Del Giudice. 2003. The quest for a vaccine against Helicobacter pylori: how to move from mouse to man? Microbes Infect. 5:749-756.
32. Satin, B., G. Del Giudice, V. Della Bianca, S. Dusi, C. Laudanna, F. Tonello, D. Kelleher, R. Rappuoli, C. Montecucco, and F. Rossi. 2000. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. J. Exp. Med. 191:1467-1476.
33. Sontag, S. J. 1997. Guilty as charged: bugs and drugs in gastric ulcer. Am. J. Gastroenterol. 92:1255-1261.
34. Sutton, P. 2001. Progress in vaccination against Helicobacter pylori. Vaccine 19:2286-2290.
35. Svennerholm, A.-M., and M. Quiding-Järbrink. 2003. Priming and expression of immune responses in the gastric mucosa. Microbes Infect. 5:731-739.
36. Uemura, N., S. Okamoto, S. Yamamoto, N. Matsumura, S. Yamaguchi, M. Yamakido, K. Taniyama, N. Sasaki, and R. J. Schlemper. 2001. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345:784-789.
37. Vajdy, M., M. Singh, M. Ugozzoli, M. Briones, E. Soenawan, L. Cuadra, J. Kazzaz, P. Ruggiero, S. Peppoloni, F. Norelli, G. Del Giudice, and D. O'Hagan. 2003. Enhanced mucosal and systemic immune responses to Helicobacter pylori antigens through mucosal followed by systemic immunizations. Immunology 110:86-94.
38. Watanabe, T., M. Tada, H. Nagai, S. Sasaki, and M. Nakao. 1998. Helicobacter pylori induces gastric cancer in Mongolian gerbils. Gastroenterology 115:642-648.
39. Weltzin, R., H. Kleanthous, F. Guirakhoo, T. P. Monath, and C. K. Lee. 1997. Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection. Vaccine 15:370-376.