Interferons in enteroviral heart disease: Modulation of cytokine expression and antiviral activity

Medical Microbiology and Immunology

Volumn 193, Issue 2-3, 2004, Pages 149-154

  Heim, Albert ^a   Weiss, Sabine ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Enterovirus; Interferon; Interleukin; MCP 1; Myocarditis

Indexed keywords

BETA INTERFERON; INTERLEUKIN 6; INTERLEUKIN 8; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENTEROVIRUS INFECTION; FIBROBLAST; HEART MUSCLE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; VIRUS MYOCARDITIS; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; ENTEROVIRUS B, HUMAN; FIBROBLASTS; HUMANS; INTERFERON ALFA-2A; INTERFERON TYPE I, RECOMBINANT; INTERFERON-GAMMA, RECOMBINANT; INTERFERONS; INTERLEUKIN-6; INTERLEUKIN-8; MYOCARDIUM;

EID: 2542550365     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-003-0200-3     Document Type: Article

References (44)

1. Afanasyeva M, Wang Y, Kaya Z, Stafford EA, Dohmen KM, Sadighi Akha AA, Rose NR (2001) Interleukin-12 receptor/ STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. Circulation 104:3145-3151
2. Black TL, Safer B, Hovanessian A, Katze MG (1989) The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J Virol 63:2244-2251
3. Bocci V, Pessina GP, Paulesu L, Muscettola M, Valeri A (1988) The lymphatic route. V. Distribution of human natural interferon-beta in rabbit plasma and lymph. J Interferon Res 8:633-640
4. Chieux V, Chehadeh W, Harvey J, Haller O, Wattre P, Hober D (2001) Inhibition of coxsackievirus B4 replication in stably transfected cells expressing human MxA protein. Virology 283:84-92
5. Dodd DA, Giddings TH Jr, Kirkegaard K (2001) Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection. J Virol 75:8158-8165
6. Eriksson U, Kurrer MO, Sebald W, Brombacher F, Kopf M (2001) Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167:5464-5469
7. Fierlbeck G, Ulmer A, Schreiner T, Stroebel W, Schiebel U, Brzoska J (1996) Pharmacodynamics of recombinant IFN-beta during long-term treatment of malignant melanoma. J Interferon Cytokine Res 16:777-781
8. Figulla HR, Stille-Siegener M, Mall G, Heim A, Kreuzer H (1995) Myocardial enterovirus infection with left ventricular dysfunction: a benign disease compared with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 25:1170-1175
9. Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ (1997) An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 272:1226-1230
10. Grumbach IM, Fish EN, Uddin S, Majchrzak B, Colamonici OR, Figulla HR, Heim A, Platanias LC (1999) Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha. J Interferon Cytokine Res 19:797-801
11. Heim A, Canu A, Kirschner P, Simon T, Mall G, Hofschneider PH, Kandolf R (1992) Synergistic interaction of interferon-beta and interferon-gamma in coxsackievirus B3-infected carrier cultures of human myocardial fibroblasts. J Infect Dis 166:958-965
12. Heim A, Brehm C, Stille-Siegener M, Muller G, Hake S, Kandolf R, Figulla HR (1995) Cultured human myocardial fibroblasts of pediatric origin: natural human interferon-alpha is more effective than recombinant interferon-alpha 2a in carrier-state coxsackievirus B3 replication. J Mol Cell Cardiol 27:2199-2208
13. Heim A, Stille-Seigener M, Pring-Akerblom P, Grumbach I, Brehm C, Kreuzer H, Figulla HR (1996) Recombinant Interferons beta and gamma have a higher antiviral activity than interferon-alpha in coxsackievirus B3-infected carrier state cultures of human myocardial fibroblasts. J Interferon Cytokine Res 16:283-287
14. Heim A, Grumbach IM, Zeuke S, Top B (1998) Highly sensitive detection of gene expression of an intronless gene: amplification of mRNA, but not genomic DNA by nucleic acid sequence based amplification (NASBA). Nucleic Acids Res 26:2250-2251
15. Heim A, Zeuke S, Weiss S, Ruschewski W, Grumbach IM (2000) Transient induction of cytokine production in human myocardial fibroblasts by coxsackievirus B3. Circ Res 86:753-759
16. Henke A, Mohr C, Sprenger H, Graebner C, Stelzner A, Nain M, Gemsa D (1992) Coxsackievirus B3-induced production of tumor necrosis factor-alpha, IL-1 beta, and IL-6 in human monocytes. J Immunol 148:2270-2277
17. Henke A, Zell R, Ehrlich G, Stelzner A (2001) Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis. J Virol 75:8187-8194
18. Horiuchi M, Hayashida W, Akishita M, Yamada S, Lehtonen JY, Tamura K, Daviet L, Chen YE, Hamai M, Cui TX, Iwai M, Minokoshi Y (2000) Interferon-gamma induces AT(2) receptor expression in fibroblasts by Jak/STAT pathway and interferon regulatory factor-1. Circ Res 86:233-240
19. Jelinek A, Klocking HP (1998) In vitro toxicity of surfactants in U937 cells: cell membrane integrity and mitochondrial function. Exp Toxicol Pathol 50:472-476
20. Kandolf R, Canu A, Hofschneider PH (1985) Coxsackie B3 virus can replicate in cultured human foetal heart cells and is inhibited by interferon. J Mol Cell Cardiol 17:167-181
21. Khabar KS, Al-Zoghaibi F, Al-Ahdal MN, Murayama T, Dhalla M, Mukaida N, Taha M, Al-Sedairy ST, Siddiqui Y, Kessie G, Matsushima K (1997) The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha. J Exp Med 186:1077-1085
22. Khabar KS, Al-Zoghaibi F, Murayama T, Matsushima K, Mukaida N, Siddiqui Y, Dhalla M, Al-Ahdal MN (1997) Interleukin-8 selectively enhances cytopathic effect (CPE) induced by positive-strand RNA viruses in the human WISH cell line. Biochem Biophys Res Commun 235:774-778
23. Khan OA, Xia Q, Bever CT Jr, Johnson KP, Panitch HS, Dhib-Jalbut SS (1996) Interferon beta-1b serum levels in multiple sclerosis patients following subcutaneous administration. Neurology 46:1639-1643
24. Klingel K, Selinka HC, Zell R, Mall G, Bultmann B, Kandolf R (1998) [Pathogenesis, diagnosis and therapy of heart disease caused by enteroviruses (molecular biological study)]. Patol Fiziol Eksp Ter: 5-10
25. Komatsu T, Bi Z, Reiss CS (1996) Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons. J Neuroimmunol 68:101-108
26. Lehmann MH, Kuhnert H, Muller S, Sigusch HH (1998) Monocyte chemoattractant protein 1 (MCP-1) gene expression in dilated cardiomyopathy. Cytokine 10:739-746
27. Lowenstein CJ, Hill SL, Lafond-Walker A, Wu J, Allen G, Landavere M, Rose NR, Herskowitz A (1996) Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest 97:1837-1843
28. Lutton CW, Gauntt CJ (1985) Ameliorating effect of IFN-beta and anti-IFN-beta on coxsackievirus B3-induced myocarditis in mice. J Interferon Res 5:137-146
29. Matsumori A, Crumpacker CS, Abelmann WH (1987) Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model. J Am Coll Cardiol 9:1320-1325
30. Miric M, Miskovic A, Vasiljevic JD, Keserovic N, Pesic M (1995) Interferon and thymic hormones in the therapy of human myocarditis and idiopathic dilated cardiomyopathy. Eur Heart J 16 Suppl O:150-152
31. Oliveira IC, Mukaida N, Matsushima K, Vilcek J (1994) Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site. Mol Cell Biol 14:5300-5308
32. Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, Hori S, Ogawa S (1997) Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res 81:611-617
33. Salmon P, Le Cotonnec JY, Galazka A, Abdul-Ahad A, Darragh A (1996) Pharmacokinetics and pharmacodynamics of recombinant human interferon-beta in healthy male volunteers. J Interferon Cytokine Res 16:759-764
34. Samuel CE (2001) Antiviral actions of interferons. Clin Microbiol Rev 14:778-809
35. Schmidtke M, Gluck B, Merkle I, Hofmann P, Stelzner A, Gemsa D (2000) Cytokine profiles in heart, spleen, and thymus during the acute stage of experimental coxsackievirus B3-induced chronic myocarditis. J Med Virol 61:518-526
36. Schneider-Fresenius C, Waschütza G, Meyer T, Heim A, Otto B (1999) Reduction of surface hydrophobicity of human IFN-beta leads to improved pharmacokinetics. ISICR (International Society for Interferon and Cytokine Research), Paris, abstract no. S 89
37. Sonnenblick M, Rosin A (1991) Cardiotoxicity of interferon. A review of 44 cases. Chest 99:557-561
38. Stille-Siegener M, Heim A, Figulla HR (1995) Subclassification of dilated cardiomyopathy and interferon treatment. Eur Heart J 16 Suppl O:147-149
39. Sun X, Delbridge LM, Dusting GJ (1998) Cardiodepressant effects of interferon-gamma and endotoxin reversed by inhibition of NO synthase 2 in rat myocardium. J Mol Cell Cardiol 30:989-997
40. Vreugdenhil GR, Wijnands PG, Netea MG, Meer JW van der, Melchers WJ, Galama JM (2000) Enterovirus-induced production of pro-inflammatory and T-helper cytokines by human leukocytes. Cytokine 12:1793-1796
41. Wessely R, Klingel K, Knowlton KU, Kandolf R (2001) Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation 103:756-761
42. Wills RJ (1990) Clinical pharmacokinetics of interferons. Clin Pharmacokinet 19:390-399
43. Yamamoto T, Tsuchihashi T, Hayashi J, Kashiwagi S (1998) Effect of interferon therapy on heart rate and sympathetic nervous system. Fukuoka Igaku Zasshi 89:207-215
44. Zaragoza C, Ocampo CJ, Saura M, Bao C, Leppo M, Lafond-Walker A, Thiemann DR, Hruban R, Lowenstein CJ (1999) Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163:5497-5504