Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans

Clinical and Experimental Immunology

Volumn 136, Issue 3, 2004, Pages 535-541

  Fatoohi, A F ^a   Cozon, G J N ^a   Gonzalo, P ^b   Mayencon, M ^a   Greenland, T ^a   Picot, S ^a   Peyron, F ^a  

^a CROIX ROUSSE HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

CD25; Cellular response; Humoral response; Toxoplasma gondii

Indexed keywords

PARASITE ANTIGEN; PROTEIN SUBUNIT;

ARTICLE; BLOOD CULTURE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FREQUENCY ANALYSIS; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; IMMUNOMODULATION; INFECTION RESISTANCE; LYMPHOCYTE CULTURE; MALE; PARASITE VIRULENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTOZOAL INFECTION; T LYMPHOCYTE ACTIVATION; TOXOPLASMA GONDII; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; PREGNANCY; RECEPTORS, INTERLEUKIN-2; TOXOPLASMA; TOXOPLASMOSIS;

EID: 2542544259     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02466.x     Document Type: Article

References (27)

1. Pinon JM, Chemla C, Villena I et al. Early neonatal diagnosis of congenital toxoplasmosis: value of comparative enzyme-linked immunofiltration assay immunological profiles and anti-toxoplasma gondii immunoglobulin M (IgM) or IgA immunocapture and implications for postnatal theraputic strategies. J Clin Microbiol 1996; 33:579-83.
2. Denkers EY, Gazzinelli RT. Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 1998; 11:569-88.
3. Letscher-Bru V, Villard O, Risse B, Zauke M, Klein JP, Kien T. T. Protective effect of vaccination with a combination of recombinant surface antigen and interleukin-12 against toxoplasmosis in mice. Infect Immun 1998; 66:4503-6.
4. Vercammen M, Scorza A, Huygen K, De-Braekeleer J, Diet R, Jacobs D, Saman E, Verschueren H. DNA vaccination with gene encoding Toxoplasma gondii antigens GRA1, GRA7 and Rop2 induce partially protective immunity against lethal challenge in mice. Infect Immun 2000; 68:38-45.
5. Prigione I, Facchette P, Lecordier L, Deslle D, Chiesa S, Cesbron-Delauw M-F, Pistoia V. T-cell clones raised from chronically infected healthy humans by stimulation with Toxoplasma gondii excretory-secretory antigen cross-react with live tachyzoite: characterization of the fine antigenic specificity of the clones and multiplication for vaccine development. J Immunol 2000; 164:3741-8.
6. Fatoohi AF, Cozon GJN, Greenland T, Ferrandiz J, Bienvenu J, Picot S, Peyron F. Cellular immune responses to recombinant antigens in chronically Toxoplasma gondii infected pregnant women. Clin Diagn Laboratory Immunol 2002; 9:704-7.
7. Cozon GJN, Roure C, Lizard G, Greenland T, Larget-Piet D, Gandillon F, Peyron F. An improved assay for the detection of Toxoplasma gondii antibodies in human serum by flow cytometry. Cytometry 1993; 14:569-75.
8. Kahi S, Cozon GJN, Greenland T, Wallon M, Gay-Andrieu F, Peyron F. Rapid flow cytometric method to explore cellular immunity against Toxoplasma gondii in humans. Clin Diag Laboratory Immunol 1998; 5:745-8.
9. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
10. Rabilloud T. Detecting proteins separated by 2-D gel electrophoresis. Anal Chem 2000; 72:48A-55A.
11. Abou-Zeid C, Filly E, Steele J, Rook GA. A simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes in vitro after converting bands cut from Western blots into antigen-bearing particles. J Immunol Meth 1987; 98:5-10.
12. Kahi S, Cozon GJN, Pinon JM, Greenland T, Wallon MAL, Kurdi M, Ferrandiz J, Peyron F. A switch towards Th2 during serological rebound in children with congenital toxoplasmosis. Clin Exp Immunol 1999; 117:524-8.
13. Caruso A, Licenziati S, Canaris AD et al. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 1997; 27:71-6.
14. Diechmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J Exp Med 2001; 193:1303-10.
15. Ridgway W, Fasso M, Fathman G. Following antigen challenge, T cell up-regulate cell surface expression of CD4 in vitro and in vivo. J Immunol 1998; 161:714-20.
16. Cesbron-Delauw MF. Reviews dense granules organelles of Toxoplasma gondii: their role in the host parasite relationship. Parasitol Today 1994; 10:293-5.
17. Couvreur G, Sadak A, Fortier B, Dubremetz JF. Surface antigens of Toxoplasma gondii. Parasitology 1988; 97:1-10.
18. Meissner M, Reiss M, Viebig N, Carruthers VB, Toursel C, Tomavo S, Ajioka JW, Soldati D. A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters. J Cell Biol 2002; 115:563-74.
19. Yang S, Parmley SF. A bradyzoite - expressed gene of Toxoplasma gondii encodes a polypeptide homologous to lactate dehydrogenase. Mol Biochem Parasitol 1995; 73:291-4.
20. Boothroyd C, Hehl A, Knoll LJ, Manger ID. The surface of Toxoplasma: more or less. Int J Parasitol 1998; 28:3-9.
21. Jacobs D, Vercammen M, Saman E. Evaluation of recombinant dense granule antigen 7 (GRA7) of Toxoplasma gondii for detection of immunoglobulin G antibodies and analysis of a major antigenic domain. Clin Diag Laboratory Immunol 1999; 6:24-9.
22. Chen M, Aosai F, Mun H, Norose K, Hata H, Yano A. Anti-HSP70 autoantibody by B-1 cells in Toxoplasma gondii-infected mice. Infect Immun 2000; 68:4895-9.
23. Rojas PA, Martin V, Nigro M, Echeverria PC, Guarnera EA, Pszenny V, Angel SO. Expression of a cDNA encoding Toxoplasma gondii protein belonging to the heat-shock 90 family and analysis of its antigenicity. FEMS Microbiol Lett 2000; 15:209-13.
24. Villavedra M, Battistoni JJ, Rossi S, Carol H, Nieto A. Avidity analysis of the human immune response to a chitin binding protein of Toxoplasma gondii. Int J Parasitol 2001; 31:1087-92.
25. Burg JL, Perelman D, Kasper LH, Ware PL, Boothroyd JC. Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii. J Immunol 1988; 141:3584-91.
26. Lecordier L, Moleon-Borodowsky I, Dubremetz JF, Tourvieille B, Mercier C, Deslee D, Capron A, Cesbron-Delauw MF. Characterization of a dense granule antigen of Toxoplasma gondii (GRA6) associated to the network of the parasitophorous vacuole. Mol Biochem Parasitol 1995; 70:85-94.
27. Dlugonska H, Dytnerska K, Reichmann G, Stachelhaus S, Fischer HG. Towards the Toxoplasma gondii proteome. position of 13 parasite excretory antigens on a standardized map of toxo-dimensionally separated tachyzoite proteins. Parasitol Res 2001; 87:634-7.