SCOPUS 정보 검색 플랫폼

Volumn 50, Issue 3, 2002, Pages 223-229

Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule

(11) Feun, Lynn a Modiano, Manuel b Lee, King c Mao, John c Marini, Angela a Savaraj, Niramol a Plezia, Patricia b Almassian, Bijan c Colacino, Elizabeth c Fischer, Jessica c MacDonald, Susan c

a UNIVERSITY OF MIAMI (United States)

b UNIVERSITY OF ARIZONA (United States)

c Vion Pharmaceuticals Incorporated (United States)

Author keywords

Pharmacokinetic; Phase I; Thiosemicarbazone

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; ANTINEOPLASTIC AGENT; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ANEMIA; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FEVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA; URINALYSIS;

ADULT; AGED; ANEMIA; BLOOD COAGULATION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEOPLASMS; PYRIDINES; THIOSEMICARBAZONES; THROMBOCYTOPENIA;

EID: 0036042522 PISSN: 03445704 EISSN: None Source Type: Journal
DOI: 10.1007/s00280-002-0480-0 Document Type: Article

Times cited : (115)

References (12)

1
- 0027934897
- Inhibitors of ribonucleotide reductase. Comparative effects of amino-and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones
- (1994) Biochem Pharmacol , vol.48 , pp. 335-344
- Cory, J.G.¹ Cory, A.H.² Rappa, G.³ Lorico, A.⁴ Liu, M.C.⁵ Lin, T.-S.⁶ Sartorelli, A.C.⁷

2
- 0015362471
- Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone
- (1972) Cancer Res , vol.32 , pp. 1455-1462
- DeConti, R.C.¹ Toftness, B.R.² Agarwal, K.C.³ Tomchick, R.⁴ Mead, J.A.R.⁵ Bertino, J.R.⁶ Sartorelli, A.C.⁷ Creasey, W.A.⁸

3
- 0033975268
- Triapine (3-aminopridine-2-carboxaldehyde thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity
- (2000) Biochem Pharmacol , vol.59 , pp. 983-991
- Finch, R.A.¹ Liu, M.-C.² Grill, S.P.³ Rose, W.G.⁴ Loomis, R.⁵ Vasquez, K.M.⁶ Cheng, T.⁷ Sartorelli, A.C.⁸

4
- 0030921076
- Differential incorporations of Ara-C, gemcitabine, and fludarabine in replicating and repairing DNA in proliferating leukemia cells
- (1997) Blood , vol.90 , pp. 270-278
- Iwasaki, H.¹ Huang, P.² Keating, M.J.³ Plunkett, W.⁴

5
- 0005466576
- Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazones
- (1971) Cancer Res , vol.31 , pp. 235-238
- Krakoff, I.H.¹ Etcubanas, E.² Tan, C.³ Mayer, K.⁴ Bethune, V.⁵ Burchenal, J.H.⁶

6
- 0026666125
- Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone
- (1992) J Med Chem , vol.35 , pp. 3672-3677
- Liu, M.-C.¹ Lin, T.-S.² Sartorelli, A.C.³

7
- 0028827448
- Synthesis and antitumor activity of 4- and 5-substituted derivative of isoquinoline-1-carboxaldehyde thiosemicarbazone
- (1995) J Med Chem , vol.38 , pp. 4234-4243
- Liu, M.-C.¹ Lin, T.-S.² Penketh, P.³ Sartorelli, A.C.⁴

8
- 0029890537
- Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone
- (1996) J Med Chem , vol.39 , pp. 2586-2593
- Liu, M.-C.¹ Lin, T.-S.² Cory, J.G.³ Cory, A.H.⁴ Sartorelli, A.C.⁵

9
- 0005396194
- A phase I and pharmacokinetic study of intravenous daily for 5 days, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in advanced cancer patients
- (2001) Proc Am Assoc Cancer Res , vol.42 , pp. 834-835
- Modiano, M.¹ Murren, J.² MacDonald, S.³ Lee, K.⁴ Mao, J.⁵ Almassian, B.⁶ Piezia, P.⁷ Sznol, M.⁸

10
- 0015028544
- Inhibition of deoxyribonucleotide synthesis by pyridine carboxaldehyde thiosemicarbazones
- (1971) Cancer Res , vol.31 , pp. 235-238
- Moore, E.C.¹ Booth, B.A.² Sartorelli, A.C.³

11
- 0029841978
- Interferon augments the cytotoxicity of hydroxyurea without enhancing its activity against the M2 subunit of ribonucleotide reductase: Effects in wildtype and resistant human colon cancer cells
- (1996) Cancer Chemother Pharmacol , vol.38 , pp. 522-528
- Wadler, S.¹ Horowitz, R.² Rao, J.³ Mao, X.⁴ Schlesinger, K.⁵ Schwartz, E.L.⁶

12
- 0005481928
- Time and sequence dependency of hydroxyurea in combination with gemcitabine in human KB cells
- (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 240
- Zhou, B.¹ Tsai² Hu, E.³ Hsu, M.⁴ Kay, K.⁵ Yen, Y.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.