Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6 mice after oral dosing of a disodium disuccinate diester of astaxanthin (Heptax™)

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 137, Issue 3, 2004, Pages 227-236

  Showalter, Lori A ^a,b   Weinman, Steven A ^a,b   Østerlie, Marianne ^c   Lockwood, Samuel F ^d  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d HAWAII BIOTECH INC   (United States)

Author keywords

Astaxanthin; AUC, area under the curve; C57BL 6 mice; Carotenoid bioavailability; Carotenoid derivatives; Hepatoprotection; Heptax ; Oral gavage; Oxidative stress; Single dose oral pharmacokinetics

Indexed keywords

ANTIOXIDANT; ASTAXANTHIN; CAROTENOID; DISODIUM DISUCCINATE DIESTER; HEPTAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RODENT; TISSUE DISTRIBUTION;

ANIMALIA; RODENTIA;

EID: 2542488315     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2003.12.006     Document Type: Article

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