Ex vivo survival of peripheral blood mononuclear cells in sheep induced by bovine leukemia virus (BLV) mainly occurs in CD5- B cells that express BLV

Microbes and Infection

Volumn 6, Issue 6, 2004, Pages 584-595

  Takahashi, Masahiko ^a,b   Tajima, Shigeru ^a   Takeshima, Shin Nosuke ^a   Konnai, Satoru ^a   Yin, Shan Ai ^c   Okada, Kosuke ^c   Davis, William C ^d   Aida, Yoko ^a  

^a RIKEN   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c IWATE UNIVERSITY   (Japan)

^d WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; BLV; CD5; Tax; Viral expression

Indexed keywords

CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR; TAX PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BOVINE LEUKEMIA VIRUS; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; EXPERIMENTAL INFECTION; FLOW CYTOMETRY; LYMPHOCYTE; LYMPHOMA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SHEEP; SHEEP DISEASE; SUPERNATANT; T LYMPHOCYTE; TRANSACTIVATION; VIRUS CELL INTERACTION; VIRUS EXPRESSION; VIRUS INFECTION; VIRUS MUTANT; WILD TYPE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD5; ANTIGENS, CD8; APOPTOSIS; B-LYMPHOCYTE SUBSETS; CATTLE; CELLS, CULTURED; DELTARETROVIRUS INFECTIONS; DISEASE PROGRESSION; ENZOOTIC BOVINE LEUKOSIS; FLOW CYTOMETRY; GENES, PX; LEUKEMIA VIRUS, BOVINE; LEUKOCYTES, MONONUCLEAR; MUTATION, MISSENSE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SHEEP;

BOVINAE; BOVINE LEUKEMIA VIRUS; OVIS ARIES;

EID: 2542446444     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.02.014     Document Type: Article

References (46)

1. Burny A., Cleuter Y., Kettmann R., Mammerickx M., Marbaix G., Portetelle D., van den Broeke A., Willems L., Thomas R. Bovine leukemia: facts and hypotheses derived from the study of an infectious cancer. Vet. Microbiol. 17:1988;197-218
2. Mirsky M.L., Olimstead C.A., Da Y., Lewin H.A. The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection. J. Virol. 70:1996;2178-2183
3. Schwartz I., Bensaid A., Polack B., Perrin B., Berthelemy M., Levy D. In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle. J. Virol. 68:1994;4589-4596
4. Stott M.L., Thurmond M.C., Dunn S.J., Osburn B.I., Stott J.L. Integrated bovine leucosis proviral DNA in T helper and T cytotoxic/suppressor lymphocytes. J. Gen. Virol. 72:1991;307-315
5. Williams D.L., Barta O., Amborski G.F. Molecular studies of T-lymphocytes from cattle infected with bovine leukemia virus. Vet. Immunol. Immunopathol. 19:1988;307-323
6. Aida Y., Okada K., Amanuma H. Phenotype and ontogeny of cells carrying a tumor-associated antigen that is expressed on bovine leukemia virus-induced lymphosarcoma. Cancer Res. 53:1993;429-437
7. Aida Y., Miyasaka M., Okada K., Onuma M., Kogure S., Suzuki M., Minoprio P., Levy D., Ikawa Y. Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep. Am. J. Vet. Res. 50:1989;1946-1951
8. Djilali S., Parodi A.L. The BLV-induced leukemia-lymphosarcoma complex in sheep. Vet. Immunol. Immunopathol. 22:1989;233-244
9. Murakami K., Aida Y., Kageyama R., Numakunai S., Ohshima K., Okada K., Ikawa Y. Immunopathologic study and characterization of the phenotype of transformed cells in sheep with bovine leukemia virus-induced lymphosarcoma. Am. J. Vet. Res. 55:1994;72-80
10. + B cells in asymptomatic stage. Virology. 202:1994;458-465
11. + B-lymphocyte subset in sheep. J. Virol. 72:1998;4413-4420
12. Twizere J.C., Kerkhofs P., Burny A., Portetelle D., Kettmann R., Willems L. Discordance between bovine leukemia virus Tax immortalization in vitro and oncogenicity in vivo. J. Virol. 74:2000;9895-9902
13. Dequiedt F., Hanon E., Kerkhofs P., Pastoret P., Portetelle D., Burny A., Kettmann R., Williems L. Both wild-type and strongly attenuated bovine leukemia viruses protect peripheral blood mononuclear cells from apoptosis. J. Virol. 71:1997;630-639
14. Schwartz-Cornil I., Chevellier N., Belloc C., Le Rhun D., Laine V., Berthelemy M., Levy D. Bovine leukemia virus-induced lymphocytosis in sheep is associated with reduction of spontaneous B cell apoptosis. J. Gen. Virol. 78:1997;153-162
15. Derse D. Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements. J. Virol. 61:1987;2462-2471
16. Willems L., Gegonne A., Chen G., Burny A., Kettmann R., Ghysdael J. The bovine leukemia virus p34 is a transactivator protein. EMBO J. 6:1987;3385-3389
17. Adam E., Kerkhofs P., Mammerickx M., Kettmann R., Burny A., Droogmans L., Willems L. Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo. J. Virol. 68:1994;5845-5853
18. Adam E., Kerkhofs P., Mammerickx M., Burny A., Kettman R., Willems L. The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression. J. Virol. 70:1996;1990-1999
19. Boros I.M., Tie F., Giam C.Z. Interaction of bovine leukemia virus transactivator Tax with bZip proteins. Virology. 214:1995;207-214
20. Willems L., Kettmann R., Chen G., Portetelle D., Burny A., Derse D. A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. J. Virol. 66:1992;766-772
21. Willems L., Heremans H., Chen G., Portetelle D., Billiau A., Burny A., Kettmann R. Cooperation between bovine leukaemia virus transactivator protein and Ha-ras oncogene product in cellular transformation. EMBO J. 9:1990;1577-1581
22. Szynal M., Cleuter Y., Beskorwayne T., Baganis C., Van Lint C., Kerkhofs P., Burny A., Martiat P., Griebel P., Van den Broke A. Disruption of B-cell homeostatic mediated by the BLV-Tax oncoprotein: association with upregulation of Bcl-2 and signaling through NF-κB. Oncogene. 22:2003;4531-4542
23. Tajima S., Aida Y. The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) Tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers. J. Virol. 74:2000;10939-10949
24. Tajima S., Aida Y. Mutant Tax protein from bovine leukemia virus with enhanced ability to activate the expression of c-fos. J. Virol. 76:2002;2557-2562
25. Tajima S., Takahashi M., Takeshima S., Konnai S., Shan Ai Y., Watarai S., Tana, Tanaka Y., Onuma M., Aida Y. A mutant form of the Tax protein of bovine leukemia virus (BLV), with enhanced transactivation activity, increases expression and propagation of BLV in vitro but in vivo. J. Virol. 77:2003;1894-1903
26. Konnai S., Takeshima S., Tajima S., Yin S.A., Okada K., Onuma M., Aida Y. The influence of ovine MHC class II DRB1 alleles on immune response in bovine leukemia virus infection. Microbiol. Immunol. 47:2003;223-232
27. Aida Y., Okada K., Ohtsuka M., Amanuma H. Tumor-associated Mr 34 000 and Mr 32 000 membrane glycoproteins that are serine phosphorylated specifically in bovine leukemia virus-induced lymphosarcoma cells. Cancer Res. 52:1992;6463-6470
28. Miyasaka M., Trnka Z. Sheep as an experimental model for immunology: immunological techniques in vitro and in vivo. Immunol. Methods. 3:1985;403-422
29. Hughes S.H., Shank P.R., Spector D.H., Kung H.J., Bishop J.M., Vermus H.E., Vogt P.K., Breitman M.L. Provirus of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Virology. 245:1978;53-64
30. Tajima S., Ikawa Y., Aida Y. Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma development. J. Virol. 72:1998;7569-7576
31. Inabe K., Ikuta K., Aida Y. Transmission and propagation in cell culture of virus produced by cells transfected with an infectious molecular clone of bovine leukemia virus. Virology. 245:1998;53-64
32. Davis W.C., Marusic S., Lewin H.A., Splitter G.A., Perryman L.E., McGuire T.C., Gorham J.R. The development and analysis of species and cross reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatibility complex for use in the study of the immune system in cattle and other species. Vet. Immunol. Immunopathol. 15:1987;337-376
33. Mackay C.R., Maddox J.F., Gogolin-Ewens K.J., Brandon M.R. Characterization of two sheep lymphocyte differentiation antigens, SBU-T1 and SBU-T6. Immunology. 55:1985;729-738
34. Beya M.F., Miyasaka M. Studies on the differentiation of T lymphocytes in sheep. III. Preliminary characterization of an antigen recognized by two anti-pan T-cell monoclonal antibodies. Immunity. 58:1986;71-77
35. Mackay C.R., Hein W.R., Brown M.H., Matzinger P. Unusual expression of CD2 in sheep: implications for T cell interactions. Eur. J. Immunol. 18:1988;1681-1688
36. Casali P., Burastero S.E., Nakamura M., Inghirami G., Notkins A.L. Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science. 236:1987;77-81
37. Cantor G.H., Pritchard S.M., Dequiedt F., Willems L., Kettmann R., Davis W.C. CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosis. J. Virol. 75:2001;1689-1696
38. Bikah G., Carey J., Ciallella J.R., Tarakhovsky A., Bondada S. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science. 274:1996;1906-1909
39. Chevallier N., Berthelemy M., Lainè V., Le Rhun D., Femenia F., Polack B., Naessens J., Levy D., Schwartz-Cornil I. B-1-like cells exist in sheep. Characterization of their phenotype and behaviour. Immunology. 95:1998;178-184
40. Akagi T., Ono H., Nyunoya H., Shimotohno K. Characterization of peripheral blood T-lymphocytes transduced with HTLV-1 Tax mutants with different trans-activating phenotypes. Oncogene. 14:1997;2071-2078
41. Robek M.D., Ranter L. Immortalization of CD4+ and CD8+ T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J. Virol. 73:1999;4856-4865
42. + T lymphocytes. J. Virol. 70:1996;2101-2106
43. Reyes R.A., Cockerell G.L. Increased ratio of bcl-2/bax expression is associated with bovine leukemia virus-induced leukemogenesis in cattle. Virology. 242:1998;184-192
44. L is up-regulated by HTLV-1 and 2 in vitro and in ex vivo ATLL samples. Blood. 96:2000;275-281
45. L expression by human T-cell leukemia virus type 1 Tax through NF-κB in apoptosis-resistant T-cell transfectants with Tax. J. Virol. 73:1999;7981-7987
46. Van den Broeke A., Cleuter Y., Beskorwayne T., Kerkhofs P., Szynal M., Bagnis C., Burny A., Griebel P. CD154 costimulated ovine primary B cells, a cell culture system that supports productive infection by bovine leukemia virus. J. Virol. 75:2001;1095-1103