메뉴 건너뛰기




Volumn 71, Issue 1, 1997, Pages 630-639

Both Wild-Type Strongly Attenuated Bovine Leukemia Viruses Protect Peripheral Blood Mononuclear Cells from Apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; DNA FRAGMENT; MONOCLONAL ANTIBODY;

EID: 0031060469     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.1.630-639.1997     Document Type: Article
Times cited : (42)

References (57)
  • 1
    • 0027518360 scopus 로고
    • Identification of alternatively spliced mRNAs encoding potential new regulatory proteins in cattle infected with bovine leukemia virus
    • Alexandersen, S., S. Carpenter, J. Christensen, T. Stordgaard, B. Viuff, Y. Wannemuehler, J. Belousov, and J. Roth. 1993. Identification of alternatively spliced mRNAs encoding potential new regulatory proteins in cattle infected with bovine leukemia virus. J. Virol. 67:39-52.
    • (1993) J. Virol. , vol.67 , pp. 39-52
    • Alexandersen, S.1    Carpenter, S.2    Christensen, J.3    Stordgaard, T.4    Viuff, B.5    Wannemuehler, Y.6    Belousov, J.7    Roth, J.8
  • 2
    • 0026552635 scopus 로고
    • Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and primary uncultured cells from patients with adult T-cell leukemia/ lymphoma and healthy carriers
    • Berneman, Z., R. Gartenhaus, M. Reitz, W. Blattner, A. Manns, B. Hanchard, O. Ikehara, R. Gallo, and M. Klotman. 1992. Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and primary uncultured cells from patients with adult T-cell leukemia/ lymphoma and healthy carriers. Proc. Natl. Acad. Sci. USA 89:3005-3009.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3005-3009
    • Berneman, Z.1    Gartenhaus, R.2    Reitz, M.3    Blattner, W.4    Manns, A.5    Hanchard, B.6    Ikehara, O.7    Gallo, R.8    Klotman, M.9
  • 3
    • 0028927484 scopus 로고
    • Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
    • Boudreau, N., C. J. Sympson, Z. Werb, and M. J. Bissel. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267:891-893.
    • (1995) Science , vol.267 , pp. 891-893
    • Boudreau, N.1    Sympson, C.J.2    Werb, Z.3    Bissel, M.J.4
  • 4
    • 0022340975 scopus 로고
    • Identification of the gene responsible for human T-cell leukemia virus transcriptional regulation
    • Cann, A. J., J. D. Rosenblatt, W. Wachsman, N. P. Shah, and I. S. Y. Chen. 1985. Identification of the gene responsible for human T-cell leukemia virus transcriptional regulation. Nature 318:571-574.
    • (1985) Nature , vol.318 , pp. 571-574
    • Cann, A.J.1    Rosenblatt, J.D.2    Wachsman, W.3    Shah, N.P.4    Chen, I.S.Y.5
  • 5
    • 0026515141 scopus 로고
    • Complex splicing in the human T-cell leukemia virus (HTLV) family retrovirus: Novel mRNAs and proteins produced by HTLV type I
    • Ciminale, V., G. Pavlakis, D. Derse, C. Cunningham, and B. Felber. 1992. Complex splicing in the human T-cell leukemia virus (HTLV) family retrovirus: novel mRNAs and proteins produced by HTLV type I. J. Virol. 66:1737-1745.
    • (1992) J. Virol. , vol.66 , pp. 1737-1745
    • Ciminale, V.1    Pavlakis, G.2    Derse, D.3    Cunningham, C.4    Felber, B.5
  • 6
    • 0030043436 scopus 로고    scopus 로고
    • A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo
    • Cockerell, G. L., J. Rovnak, P. L. Green, and I. S. Y. Chen. 1996. A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo. Blood 87:1030-1035.
    • (1996) Blood , vol.87 , pp. 1030-1035
    • Cockerell, G.L.1    Rovnak, J.2    Green, P.L.3    Chen, I.S.Y.4
  • 9
    • 0023193905 scopus 로고
    • Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements
    • Derse, D. 1987. Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements. J. Virol. 61:2462-2471.
    • (1987) J. Virol. , vol.61 , pp. 2462-2471
    • Derse, D.1
  • 10
    • 0023860023 scopus 로고
    • Trans-acting regulation of bovine leukemia virus mRNA processing
    • Derse, D. 1988. Trans-acting regulation of bovine leukemia virus mRNA processing. J. Virol. 62:1115-1119.
    • (1988) J. Virol. , vol.62 , pp. 1115-1119
    • Derse, D.1
  • 12
    • 0022368647 scopus 로고
    • The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
    • Felber, B. K., H. Paskalis, C. Kleinman-Ewing, F. Wong-staal, and G. N. Pavlakis. 1985. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 229:675-679.
    • (1985) Science , vol.229 , pp. 675-679
    • Felber, B.K.1    Paskalis, H.2    Kleinman-Ewing, C.3    Wong-staal, F.4    Pavlakis, G.N.5
  • 15
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assay
    • Gorczyca, W., J. Gong, and Z. Darzynkiewicz. 1993. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assay. Cancer Res. 53:1945-1951.
    • (1993) Cancer Res. , vol.53 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 16
  • 17
    • 0028924004 scopus 로고
    • Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation
    • Green, P. L., T. M. Ross, I. S. Y. Chen, and S. Pettiford. 1995. Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation. J. Virol. 69:387-394.
    • (1995) J. Virol. , vol.69 , pp. 387-394
    • Green, P.L.1    Ross, T.M.2    Chen, I.S.Y.3    Pettiford, S.4
  • 18
    • 0025772343 scopus 로고
    • Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death
    • Henderson, S., M. Rowe, C. Gregory, D. Croom-Carter, F. Wang, R. Longnecker, E. Kieff, and A. Rickinson. 1991. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65:1107-1115.
    • (1991) Cell , vol.65 , pp. 1107-1115
    • Henderson, S.1    Rowe, M.2    Gregory, C.3    Croom-Carter, D.4    Wang, F.5    Longnecker, R.6    Kieff, E.7    Rickinson, A.8
  • 19
    • 0026459409 scopus 로고
    • Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and cell lines after in vitro infection
    • Jeurissen, S. H. M., F. Wagenaar, J. M. A. Pol, A. J. van der Eb, and M. H. M. Noteborn. 1992. Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and cell lines after in vitro infection. J. Virol. 66:7383-7388.
    • (1992) J. Virol. , vol.66 , pp. 7383-7388
    • Jeurissen, S.H.M.1    Wagenaar, F.2    Pol, J.M.A.3    Van der Eb, A.J.4    Noteborn, M.H.M.5
  • 20
    • 1542672914 scopus 로고    scopus 로고
    • Unpublished data
    • 19a.Kerkhofs, P., et al. Unpublished data.
    • Kerkhofs, P.1
  • 22
    • 0029062573 scopus 로고
    • Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
    • Li, C. J., D. J. Friedman, C. Wang, V. Metelev, and A. B. Pardee. 1995. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429-431.
    • (1995) Science , vol.268 , pp. 429-431
    • Li, C.J.1    Friedman, D.J.2    Wang, C.3    Metelev, V.4    Pardee, A.B.5
  • 23
    • 0029100490 scopus 로고
    • Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1
    • Maldarelli, F., H. Sato, E. Berthold, J. Orenstein, and M. A. Martin. 1995. Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1. J. Virol. 69:6457-6465.
    • (1995) J. Virol. , vol.69 , pp. 6457-6465
    • Maldarelli, F.1    Sato, H.2    Berthold, E.3    Orenstein, J.4    Martin, M.A.5
  • 26
    • 0027451661 scopus 로고
    • Detection of bovine leukemia virus proviral DNA in individuals cells
    • Mirsky, M. L., Y. Da, and H. A. Lewin. 1993. Detection of bovine leukemia virus proviral DNA in individuals cells. PCR Methods Appl. 2:333-339.
    • (1993) PCR Methods Appl. , vol.2 , pp. 333-339
    • Mirsky, M.L.1    Da, Y.2    Lewin, H.A.3
  • 28
    • 0027978733 scopus 로고
    • Bovine leukemia virus induces CD5- B cell lymphoma in sheep despite temporarily increasing CD5+ B cells in asymptomatic stage
    • Murakami, K., K. Okada, Y. Ikawa, and Y. Aida. 1994. Bovine leukemia virus induces CD5- B cell lymphoma in sheep despite temporarily increasing CD5+ B cells in asymptomatic stage. Virology 202:458-465.
    • (1994) Virology , vol.202 , pp. 458-465
    • Murakami, K.1    Okada, K.2    Ikawa, Y.3    Aida, Y.4
  • 29
    • 0024602744 scopus 로고
    • Use of two monoclonal antibodies in an ELISA test for the detection of antibodies to bovine leukemia virus envelope protein gp51
    • Portetelle, D., M. Mammerickx, and A. Burny. 1989. Use of two monoclonal antibodies in an ELISA test for the detection of antibodies to bovine leukemia virus envelope protein gp51. J. Virol. Methods 23:211-222.
    • (1989) J. Virol. Methods , vol.23 , pp. 211-222
    • Portetelle, D.1    Mammerickx, M.2    Burny, A.3
  • 30
    • 0026058120 scopus 로고
    • Recombinant vaccinia virus virus expression of the bovine leukemia virus envelope and protection of immunized sheep against infection
    • Portetelle, D., K. Limbach, A. Burny, M. Mammerickx, P. Desmettre, M. Rivière, J. Zavada, and E. Paoletti. 1991. Recombinant vaccinia virus virus expression of the bovine leukemia virus envelope and protection of immunized sheep against infection. Vaccine 9:194-200.
    • (1991) Vaccine , vol.9 , pp. 194-200
    • Portetelle, D.1    Limbach, K.2    Burny, A.3    Mammerickx, M.4    Desmettre, P.5    Rivière, M.6    Zavada, J.7    Paoletti, E.8
  • 31
    • 0025037838 scopus 로고
    • The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogcne to induce neoplastic transformation of cells
    • Pozzatti, R., J. Vogel, and G. Jay. 1990. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogcne to induce neoplastic transformation of cells. Mol. Cell. Biol. 10:413-417.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 413-417
    • Pozzatti, R.1    Vogel, J.2    Jay, G.3
  • 32
    • 0026504147 scopus 로고
    • Social control on cell survival and cell death
    • Raff, M. C. 1992. Social control on cell survival and cell death. Nature 356:397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 33
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bcl-2 proteins
    • Rao, L., M. Debbas, P. Sabbatini, D. Hockenbery, S. Korsmeyer, and E. White. 1992. The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA 89:7742-7746.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7742-7746
    • Rao, L.1    Debbas, M.2    Sabbatini, P.3    Hockenbery, D.4    Korsmeyer, S.5    White, E.6
  • 34
    • 0029136149 scopus 로고
    • Apoptosis in viral infections
    • Razvi, E. S., and R. M. Welsh. 1995. Apoptosis in viral infections. Adv. Virus Res. 45:1-60.
    • (1995) Adv. Virus Res. , vol.45 , pp. 1-60
    • Razvi, E.S.1    Welsh, R.M.2
  • 35
    • 0001827959 scopus 로고
    • Sequence analysis of the bovine leukemia virus genome
    • A. Burny and M. Mammerickx (ed.). Nijhoff, The Hague, The Netherlands
    • Rice, N., R. Stephens, and R. Gilden. 1987. Sequence analysis of the bovine leukemia virus genome, p. 115-144. In A. Burny and M. Mammerickx (ed.), Enzootic bovine leukosis and bovine leukemia virus. Nijhoff, The Hague, The Netherlands.
    • (1987) Enzootic Bovine Leukosis and Bovine Leukemia Virus , pp. 115-144
    • Rice, N.1    Stephens, R.2    Gilden, R.3
  • 37
    • 0023930054 scopus 로고
    • Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product
    • Ruben, S., H. Poteat, T. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C. A. Rosen. 1988. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science 241:89-92.
    • (1988) Science , vol.241 , pp. 89-92
    • Ruben, S.1    Poteat, H.2    Tan, T.3    Kawakami, K.4    Roeder, R.5    Haseltine, W.6    Rosen, C.A.7
  • 38
    • 0011310662 scopus 로고
    • Complete nucleotide sequence of the genome of bovine leukemia virus: Its evolutionary relationship to the other retroviruses
    • Sagata, N., T. Yasunaga, J. Tsukuzu-Kawamura, K. Ohishi, Y. Ogawa, and Y. Ikawa. 1985. Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to the other retroviruses. Proc. Natl. Acad. Sci. USA 82:677-681.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 677-681
    • Sagata, N.1    Yasunaga, T.2    Tsukuzu-Kawamura, J.3    Ohishi, K.4    Ogawa, Y.5    Ikawa, Y.6
  • 39
    • 0028359848 scopus 로고
    • In vivo leucocyte tropism of bovine leukemia virus in sheep and cattle
    • Schwartz, I., A. Bensaid, B. Polak, B. Perrin, M. Berthelemy, and D. Levy. 1994. In vivo leucocyte tropism of bovine leukemia virus in sheep and cattle. J. Virol. 68:4589-4596.
    • (1994) J. Virol. , vol.68 , pp. 4589-4596
    • Schwartz, I.1    Bensaid, A.2    Polak, B.3    Perrin, B.4    Berthelemy, M.5    Levy, D.6
  • 40
    • 1542686422 scopus 로고
    • Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA
    • Seiki, M., S. Hattori, Y. Hirayama, and M. Yoshida. 1983. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc. Natl. Acad. Sci. USA 80:3618-3622.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3618-3622
    • Seiki, M.1    Hattori, S.2    Hirayama, Y.3    Yoshida, M.4
  • 41
    • 0022688252 scopus 로고
    • Direct evidence that the p40x of the human T-cell leukemia virus type-I is a trans-acting transcriptional activator
    • Seiki, M., J. Inoue, T. Takeda, and M. Yoshida. 1986. Direct evidence that the p40x of the human T-cell leukemia virus type-I is a trans-acting transcriptional activator. EMBO J. 5:561-565.
    • (1986) EMBO J. , vol.5 , pp. 561-565
    • Seiki, M.1    Inoue, J.2    Takeda, T.3    Yoshida, M.4
  • 42
    • 0010293636 scopus 로고
    • Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type-I
    • Seiki, M., J. Inoue, M. Hidaka, and M. Yoshida. 1988. Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type-I. Proc. Natl. Acad. Sci. USA 85:7124-7128.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7124-7128
    • Seiki, M.1    Inoue, J.2    Hidaka, M.3    Yoshida, M.4
  • 43
    • 0025245774 scopus 로고
    • Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes
    • Smith, M. R., and W. C. Greene. 1990. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4:1875-1885.
    • (1990) Genes Dev. , vol.4 , pp. 1875-1885
    • Smith, M.R.1    Greene, W.C.2
  • 45
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thomson, C. B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thomson, C.B.1
  • 47
    • 0026049728 scopus 로고
    • Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A protein
    • White, E., R. Cipriani, P. Sabbatini, and A. Denton. 1991. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A protein. J. Virol. 65:2968-2978.
    • (1991) J. Virol. , vol.65 , pp. 2968-2978
    • White, E.1    Cipriani, R.2    Sabbatini, P.3    Denton, A.4
  • 48
    • 0026773471 scopus 로고
    • The 19-kilodallon adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor α
    • White, E., P. Sabbatini, M. Debbas, W. S. M. Wold, D. I. Kusher, and L. Gooding. 1992. The 19-kilodallon adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor α. Mol. Cell. Biol. 12:2570-2580.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2570-2580
    • White, E.1    Sabbatini, P.2    Debbas, M.3    Wold, W.S.M.4    Kusher, D.I.5    Gooding, L.6
  • 50
    • 0024337905 scopus 로고
    • Structural and functional characterization of mutants of the bovine leukemia virus transactivator protein p34
    • Willems, L., G. Chen, D. Portetelle, R. Mamoun, A. Burny, and R. Kettmann. 1989. Structural and functional characterization of mutants of the bovine leukemia virus transactivator protein p34. Virology 171:615-618.
    • (1989) Virology , vol.171 , pp. 615-618
    • Willems, L.1    Chen, G.2    Portetelle, D.3    Mamoun, R.4    Burny, A.5    Kettmann, R.6
  • 51
    • 0025264327 scopus 로고
    • Cooperation between bovine leukemia virus transactivator protein and Ha-ras oncogene product in cellular transformation
    • Wilkms, L., H. Heremans, G. Chen, D. Portetelle, A. Billiau, A. Burny, and R. Kettmann. 1990. Cooperation between bovine leukemia virus transactivator protein and Ha-ras oncogene product in cellular transformation. EMBO J. 9:1577-1581.
    • (1990) EMBO J. , vol.9 , pp. 1577-1581
    • Wilkms, L.1    Heremans, H.2    Chen, G.3    Portetelle, D.4    Billiau, A.5    Burny, A.6    Kettmann, R.7
  • 52
    • 0026506019 scopus 로고
    • Mutations in the bovine leukemia virus tax protein can abrogate the long terminal repeat-directed trans-activating activity without concomitant loss of transforming potential
    • Willems, L., C. Grimonpont, H. Heremans, N. Rebeyrotte, G. Chen, D. Portetelle, A. Burny, and R. Kettmann. 1992. Mutations in the bovine leukemia virus tax protein can abrogate the long terminal repeat-directed trans-activating activity without concomitant loss of transforming potential. Proc. Natl. Acad. Sci. USA 89:3957-3961.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3957-3961
    • Willems, L.1    Grimonpont, C.2    Heremans, H.3    Rebeyrotte, N.4    Chen, G.5    Portetelle, D.6    Burny, A.7    Kettmann, R.8
  • 55
    • 0028227038 scopus 로고
    • The human T-cell leukemia virus type 1 Tax protein induces apoptosis which is blocked by the Bcl-2 protein
    • Yamada, T., S. Yamaoka, T. Goto, M. Nakai, Y. Tsujimoto, and M. Hatanaka. 1994. The human T-cell leukemia virus type 1 Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J. Virol. 68:3374-3379.
    • (1994) J. Virol. , vol.68 , pp. 3374-3379
    • Yamada, T.1    Yamaoka, S.2    Goto, T.3    Nakai, M.4    Tsujimoto, Y.5    Hatanaka, M.6
  • 56
    • 0029670843 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein
    • Yamaoka, S., H. Inoue, M. Sakurai, T. Sugiyama, M. Hazama, T. Yamada, and M. Hatanaka. 1996. Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J. 15:873-887.
    • (1996) EMBO J. , vol.15 , pp. 873-887
    • Yamaoka, S.1    Inoue, H.2    Sakurai, M.3    Sugiyama, T.4    Hazama, M.5    Yamada, T.6    Hatanaka, M.7
  • 57
    • 0028810985 scopus 로고
    • The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells
    • Zauli, G., D. Gibellini, A. Caputo, A. Bassini, M. Negrini, M. Monne, M. Mazzoni, and S. Capitani. 1995. The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Blood 86:3823-3834.
    • (1995) Blood , vol.86 , pp. 3823-3834
    • Zauli, G.1    Gibellini, D.2    Caputo, A.3    Bassini, A.4    Negrini, M.5    Monne, M.6    Mazzoni, M.7    Capitani, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.