Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression

NeuroImmunoModulation

Volumn 12, Issue 5, 2005, Pages 299-306

  Lima, L ^a,b   Mata, S ^b   Urbina, M ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Hospital Vargas de Caracas   (Venezuela)

Author keywords

Lymphocytes; Major depression; mRNA; Polymorphism 5HTTLPR; Serotonin; Serotonin transporter

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ANTIBODY; BETA ACTIN; CD3 ANTIGEN; MESSENGER RNA; SEROTONIN; SEROTONIN TRANSPORTER;

5' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; HAMILTON SCALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPHOCYTE; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ALLELES; BIOLOGICAL MARKERS; DEPRESSIVE DISORDER, MAJOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYDROXYINDOLEACETIC ACID; LYMPHOCYTES; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN;

EID: 24944577469     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087108     Document Type: Article

References (43)

1. Gross-Osseroff R, Israili M, Biegon A: Autoradiographic analysis of initiated imipramine binding in the human brain post mortem: Effects of suicide. Arch Gen Psychiatry 1989;46:237-241.
2. 3H-paroxetine. Psychopharmacology 1993;110:235-239.
3. 3H]Paroxetine binding to human peripheral lymphocyte membranes of patients with major depression before and after treatment with fluoxetine. Int J Immunopharmacol 1999;21:631-646.
4. Owens MJ, Nemeroff CB: Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clin Chem 1994;40:288-295.
5. Baccichet E, Peña S: Transportador de serotonina en linfocitos de sangre periférica de pacientes con trastorno depresivo mayor antes y después del tratamiento con mirtazapina. Trabajo Especial de Investigación, Especialista en Psiquiatría, Facultad de Medicina, Universidad Central de Venezuela, 2001.
6. Ramomoorthy S, Bauman AL, Moore KR, Han H, Yan-Feng T, Chan AS, Ganapathy V, Blakely RD: Antidepressant- and cocaine-sensitive human serotonin transporter molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993;90:2542-2546.
7. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P: Organization of the human serotonin transporter gene. J Neural Transm 1994;95:157-162.
8. Heils A, Teufe A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP: Allellic variation of human serotonin transporter gene expression. J Neurochem 1996;66:2621-2624.
9. Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL: Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol Psychiatry 2002;7:213-216.
10. Narita M, Nishigami N, Narita N, Yamaguti K, Okado N, Watanabe Y, Kuratsune H: Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biopys Res Commun 2003;311:264-266.
11. Willeit M, Praschak-Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, Hilger E, Thierry N, Konstantinidis A, Winkler D, Fuchs K, Sieghart W, Aschauer H, Ackenheil M, Bondy B, Kasper S: A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry 2003;8:942-946.
12. Juhasz G, Zsombok T, Laszik A, Jakus R, Faludi G, Sotonyl P, Bagdy G: Despite the general correlation of the serotonin transporter gene regulatory region polymorphism (5-HT-TLPR) and platelet serotonin concentration, lower platelet serotonin concentration in migraine patients is independent of the 5-HTTL-PR variants. Neurosci Lett 2003;16:56-60.
13. Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B, Smeraldi E: Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biol Psychiatry 2003;54:687-692.
14. Yu YW, Tsai SJ, Chen TJ, Lin CH, Hong CJ: Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol Psychiatry 2002;7:1115-1119.
15. Serretti A, Zanardi R, Rossini D, Cusin C, Lilli R, Smeraldi E: Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Mol Psychiatry 2001;6:586-592.
16. Durham LK, Webb SM, Milos PM, Clary CM, Seymour AB: The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder. Psychopharmacology (Berl) 2004;174:525-529.
17. Arango V, Huang Y, Underwood MD, Mann JJ: Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res 2003;37:375-386.
18. Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Nelly TM, Dwork AJ, Arango V: A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 2000;57:729-738.
19. Lotrich FE, Pollock BG, Ferrell RE: Polymorphism of the serotonin transporter: Implications for the use of selective serotonin reuptake inhibitors. Am J Pharmacogenomics 2001;1:153-164.
20. Serreti A, Cusin C, Lattuada E, Di Bella D, Catalano M, Smeraldi E: Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders. Mol Psychiatry 1999;4:280-283.
21. Oliveira JR, Gallindo RM, Maia LG, Brito-Marques PR, Otto PA, Passos-Bueno MR, Morais MA, Zatz M: The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Mol Psychiatry 1998;3:438-441.
22. Serreti A, Macciardi F, Di Bella D, Catalano M, Smeraldi E: Self-esteem in remitted patients with mood disorders is not associated with the dopamine receptor D4 and the serotonin transporter genes. Psychiatry Res 1998;80:137-144.
23. Lin PY, Tsai G: Association between serotonin transporter gene promoter polymorphism and suicide: Results of a meta-analysis. Biol Psychiatry 2004;55:1023-1030.
24. Lang UE, Bajbouj M, Wernicke C, Rommelspacher H, Danker-Hopfe H, Gallinat J: No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits. Neuropsychobiology 2004;49:182-184.
25. Serreti A: Lithium long-term treatment in mood disorders: Clinical and genetic predictors. Pharmacogenomics 2002;3:117-129.
26. Serretti A, Malitas PN, Mandelli L, Lorenzi C, Ploia C, Alevizos B, Nikolaou C, Boufidou F, Christodoulou GN, Smeraldi E: Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders. Pharmacogenomics J 2004;4:267-273.
27. Mendlewicz J, Massat I, Souery D, Del-Favero J, Oruc L, Nothen MM, Blackwood D, Miui W, Battersby S, Lerer B, Segman RH, Kaneva R, Serretti A, Lilli R, Lorenzi C, Jakovljevic M, Ivezic S, Rietschel M, Milanova V, Van Broeckhoven C: Serotonin transporter 5HT-TLPR polymorphism and affective disorders: No evidence of association in a large European multicenter study. Eur J Hum Genet 2004;12:377-382.
28. Hamilton MA: A rating scale of depression. J Neurol Neurosurg 1960;23:56-62.
29. Moltusky H: Intuitive Statistcs. New York, Oxford University Press, 1995.
30. Lesch K, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
31. Serreti A, Artioli P: From molecular biology to pharmacogenetics: A review of the literature on antidepressant treatment and suggestions of possible candidate genes. Psychopharmacology 2004;174:490-503.
32. Yen FC, Hong CJ, Hou SJ, Wang JK, Tsai SJ: Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample. Neuropsychobiology 2003;48:5-9.
33. Mazzola-Pomietto P, Azorin J-M, Tramoni V, Jeanningros R: Relation between lymphocyte β-adrenergic responsivity and the severity of depressive disorders. Biol Psychiatry 1994;35:920-925.
34. Mann JJ, Brown RP, Halper JP, Sweeney JA, Kocsis JH, Stokes PE, Bilezikian JP: Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. N Engl J Med 1985;313:715-720.
35. Lima L, Obregón F, Urbina M, Carreira I, Baccichet E, Peña S: Taurine concentration in human blood peripheral lymphocytes: Major depression and treatment with the antidepressant mirtazapine. Adv Exp Med Biol 2003;526:297-304.
36. Maes M, Bosmans E, Suy E, Minner B, Raus J: Immune cell parameters in severely depressed patients: Negative findings. J Affect Disord 1989;17:121-128.
37. 3H]paroxetine binding in premenstrual dysphoria. Psychoneuroendocrinology 2003;28:446-458.
38. Bartolini C, Guido L, Frasca D, Antico L, Pili R, Di Giovanni A, Rumi C, Menini E, Carbonini P: Immune parameters in a population of institutionalized elderly subjects: Influence of depressive disorders and endocrinological correlations. Mech Ageing Dev 1991;60:1-12.
39. Shek PN, Sabiston BH, Buguet A, Radomski MW: Strenous exercise and immunologjcal changes: A multiple-time-point analysis of leukocyte subsets, CD4/CD3 ratio, immunoglobulin production and NK cell response. Int J Sports Med 1995;16:466-474.
40. Marazitti D, Ambreogi F, Vanacore R, Mignani V, Savino M, Palego L, Cassano GB, Akiskal HS: Immune cell imbalance in major depressive and panic disorders. Neuropsychobiology 1992;26:23-26.
41. 1A receptors and dopamine in blood peripheral lymphocytes of major depression patients. Int Immunopharmacol 2003;3:1345-1352.
42. Mizrahi C, Stojanovic A, Urbina M, Carreira I, Lima L: Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients. Int Immunopharmacol 2004;4:1125-1133.
43. Mata S, Urbina M, Manzano E, Ortiz T, Lima L: Noradrenaline transporter is decreased in blood peripheral lymphocytes of patients with major depression. Int Immunopharmacol, in press.