Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample

Neuropsychobiology

Volumn 48, Issue 1, 2003, Pages 5-9

  Yen, Feng Chang ^a   Hong, Chen Jee ^a,b   Hou, Sheu Jane ^a   Wang, Jiunn Kae ^a   Tsai, Shih Jen ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Age at onset; Association study; Bipolar disorder; Major depressive disorder; Polymorphism; Serotonin transporter; Suicide

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; BIPOLAR DISORDER; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD DISORDER; ONSET AGE; PATH ANALYSIS; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; SUICIDE ATTEMPT; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; CASE-CONTROL STUDIES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MINISATELLITE REPEATS; MOOD DISORDERS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE, ATTEMPTED;

EID: 0041672540     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071821     Document Type: Article

References (38)

1. Greenberg BD, McMahon FJ, Murphy DL: Serotonin transporter candidate gene studies in affective disorders and personality: Promises and potential pitfalls. Mol Psychiatry 1998;3:186-189.
2. Spigset O: Adverse reactions of selective serotonin reuptake inhibitors: Reports from a spontaneous reporting system. Drug Saf 1999;20:277-287.
3. Ellis PM, Salmond C: Is platelet imipramine binding reduced in depression? A meta-analysis. Biol Psychiatry 1994;36:292-299.
4. Leboyer M, Quintin P, Manivet P, Varoquaux O, Allilaire JF, Launay JM: Decreased serotonin transporter binding in unaffected relatives of manic depressive patients. Biol Psychiatry 1999;46:1703-1706.
5. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD: Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993;90:2542-2546.
6. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P: Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-162.
7. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP: Allelic variation of human serotonin transporter gene expression. J Neurochem 1996;66:2621-2624.
8. MacKenzie A, Quinn J: A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 1999;96:15251-15255.
9. Kaiser R, Muller-Oerlinghausen B, Filler D, Tremblay PB, Berghofer A, Roots I, Brockmoller J: Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Am J Med Genet 2002;114:323-328.
10. Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P, Aitchison KJ, Sodhi M, Li T, Roberts GW, Smith B, Morton J, Murray RM, Smith D, Kirov G: The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 1996;7:1675-1679.
11. Craddock N, Owen MJ: Candidate gene association studies in psychiatric genetics: A SERTain future? Mol Psychiatry 1996;1:434-436.
12. Heiden A, Schussler P, Itzlinger U, Leisch F, Scharfetter J, Gebhardt C, Fuchs K, Willeit M, Nilsson L, Miller-Reiter E, Stompe T, Meszaros K, Sieghart W, Hornik K, Kasper S, Aschauer HN: Association studies of candidate genes in bipolar disorders. Neuropsychobiology 2000;42(suppl 1):18-21.
13. Rees M, Norton N, Jones I, McCandless F, Scourfield J, Holmans P, Moorhead S, Feldman E, Sadler S, Cole T, Redman K, Farmer A, McGuffin P, Owen MJ, Craddock N: Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 1997;2:398-402.
14. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T, Hirose T, Nanko S: Serotonin transporter gene polymorphisms: Ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 1997;2:457-462.
15. Stober G, Heils A, Lesch KP: Serotonin transporter gene polymorphism and affective disorder. Lancet 1996;347:1340-1341.
16. Hoehe MR, Wendel B, Grunewald I, Chiaroni P, Levy N, Morris-Rosendahl D, Macher JP, Sander T, Crocq MA: Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet 1998;81:1-3.
17. Mellerup E, Bennike B, Bolwig T, Dam H, Hasholt L, Jorgensen MB, Plenge P, Sorensen SA: Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients. Acta Psychiatr Scand 2001;103:229-233.
18. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC: Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 1998;81:58-63.
19. Gutierrez B, Arranz MJ, Collier DA, Valles V, Guillamat R, Bertranpetit J, Murray RM, Fanas L: Serotonin transporter gene and risk for bipolar affective disorder: An association study in Spanish population. Biol Psychiatry 1998;43:843-847.
20. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM, Smith CA: Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996;347:731-733.
21. Saleem Q, Ganesh S, Vijaykumar M, Reddy YC, Brahmachari SK, Jain S: Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. Am J Med Genet 2000;96:170-172.
22. Liu W, Gu N, Feng G, Li S, Bai S, Zhang J, Shen T, Xue H, Breen G, St Clair D, He L: Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics 1999;9:491-495.
23. Liu W, Gu N, Feng G, Zhang J, Li S, Bai S, Shen T, Clair DS, He L: Association of VNTR region of the human serotonin transporter gene with bipolar disorder among the Han Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1998;15:345-348 [in Chinese].
24. Battersby S, Ogilvie AD, Smith CA, Blackwood DH, Muir WJ, Quinn JP, Fink G, Goodwin GM, Harmar AJ: Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatr Genet 1996;6:177-181.
25. Kirov G, Rees M, Jones I, MacCandless F, Owen MJ, Craddock N: Bipolar disorder and the serotonin transporter gene: A family-based association study. Psychol Med 1999;29:1249-1254.
26. Dimitrova A, Georgieva L, Nikolov I, Poriazova N, Krastev S, Toncheva D, Owen MJ, Kirov G: Major psychiatric disorders and the serotonin transporter gene (SLC6A4): Family-based association studies. Psychiatr Gene 2002;12:137-141.
27. Gutierrez B, Pintor L, Gasto C, Rosa A, Bertranpetit J, Vieta E, Fananas L: Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 1998;103:319-322.
28. Bellivier F, Henry C, Szoke A, Schurhoff F, Nosten-Bertrand M, Feingold J, Launay JM, Leboyer M, Laplanche JL: Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 1998; 255:143-146.
29. Kunugi H, Tatsumi M, Sakai T, Hattori M, Nanko S: Serotonin transporter gene polymorphism and affective disorder. Lancet 1996; 347:1340.
30. Bellivier F, Leroux M, Henry C, Rayah F, Rouillon F, Laplanche JL, Leboyer M: Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. Neurosci Lett 2002;334:17-20.
31. Leake A, Fairbairn AF, McKeith IG, Ferrier IN: Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: Neurochemical and clinical correlates. Psychiatry Res 1991;39:155-165.
32. Tan EC, Yeo BK, Ho BK, Tay AH, Tan CH: Evidence for an association between heroin dependence and a VNTR polymorphism at the serotonin transporter locus. Mol Psychiatry 1999;4:215-217.
33. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK: Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 1999;88:61-66.
34. Lovejoy EA, Scott AC, Fiskerstrand CE, Bubb VJ, Quinn JP: The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit. Eur J Neurosci 2003;17:417-420.
35. Baca-Garcia E, Vaquero C, Diaz-Sastre C, Saiz-Ruiz J, Fernandez-Piqueras J, de Leon J: A gender-specific association between the serotonin transporter gene and suicide attempts. Neuropsychopharmacology 2002;26:692-695.
36. Courtet P, Baud P, Abbar M, Boulenger JP, Castelnau D, Mouthon D, Malafosse A, Buresi C: Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene. Mol Psychiatry 2001;6:338-341.
37. Rujescu D, Giegling I, Sato T, Moeller HJ: A polymorphism in the promoter of the serotonin transporter gene is not associated with suicidal behavior. Psychiatry Genet 2001;11:169-172.
38. Chong SA, Lee WL, Tan CH, Tay AH, Chan AO, Tan EC: Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Res 2000;97:101-106.