Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders

Molecular Psychiatry

Volumn 4, Issue 3, 1999, Pages 280-283

  Serretti, A ^a   Cusin, C ^b   Lattuada, E ^b   Di Bella, D ^b   Catalano, M ^b   Smeraldi, E ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b NONE

Author keywords

Anxiety; Bipolar disorder; Depressive disorder; Phenotype; Polymorphism; Serotonin

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; SEROTONIN TRANSPORTER;

AFFECTIVE NEUROSIS; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MANIC DEPRESSIVE PSYCHOSIS; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RATING SCALE; REGULATOR GENE;

EID: 0032969401     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000485     Document Type: Article

References (37)

1. 1 Benkelfat C. Serotoninergic mechanisms in psychiatric disorders: new research tools, new ideas. Int Clin Psychopharmacol 1993; 8 suppl: 53-56.
2. 2 Jacobs B, Fornal G. Serotonin and behavior. A general hypothesis. In: Bloom F, Kupfer D (eds). Psychopharmacology. The Fourth Generation of Progress. Raven Press: New York, 1995, pp 461-469.
3. 3 Lesch K, Gross J, Franzek E, Wolozin B, Riederer P, Murphy D. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 1995; 37: 215-223.
4. 4 Ogilvie A, Battersby S, Bubb V, Fink G, Harmar A, Goodwin G et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733.
5. 5 Collier D, Stöber G, Li T, Heils A, Catalano M, Di Bella D et al. A novel functional polymorphism within the promoter of the: serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453-460.
6. 6 Lesch K, Bengel D, Heils A, Sabol S, Greenberg B, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1530.
7. 7 Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
8. 8 Seretti A, Macciardi F, Cusin C, Lattuada E, Lilli R, Bella DD et al. No interaction between serotonin transporter gene (5-HTTLPR) and dopamine receptor D4 gene (DRD4) in symptomatology of major psychoses. (submitted).
9. 9 Serretti A, Catalano M, Smeraldi E. Serotonin transporter gene is not associated with symptomatology of schizophrenia. Schizophr Res (in press).
10. 10 Serretti A, Lattuada E, Catalano M, Smeraldi E. Serotonin transporter gene not associated with psychotic symptomatology of mood disorders. (submitted).
11. 11 McGuffin P, Farmer A, Harvrey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 1991; 48: 764-770.
12. 12 Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278-296.
13. 13 Tsuang M, Faraone S. The Genetics of Mood Disorders. The Johns Hopkins University Press: Baltimore, 1990.
14. 14 Ball D, Hill L, Freeman B, Eley T, Strelan J, Riemann R et al. The serotonin transporter gene and peer-rated neuroticism. Neuroreport 1997; 8: 1301-1304.
15. 15 Evans E, Battersby S, Ogilvie A, Smith C, Harmar A, Nutt D et al. Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self harm. Neuropharmacology 1997; 36: 439-443.
16. 16 Rees M, Norton N, Jones I, McCandless F, Scourfield J, Holmans P et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 1997; 2: 398-402.
17. 17 Oruc L, Verheyen G, Furac I, Jakovljevic M, Ivezic S, Raeymaekers P et al. Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. Am J Med Gen 1997; 74: 504-506.
18. 18 Kelsoe J, Remick R, Sadovnick A, Kristbjarnarson H, Flodman P, Spence M et al. Genetic linkage study of bipolar disorder and the serotonin transporter. Am J Med Gen 1996; 67: 215-217.
19. 19 Ebstein R, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker R. No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 1997; 2: 224-226.
20. 20 Cohen J. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum: Hillsdale, NJ. 1988.
21. 21 Comings D. Polygenic inheritance in psychiatric disorders. In: Blum K, Noble EP (eds). Handbook of Psychiatric Genetics. CRC Press: Boca Raton, 1997, pp 235-260.
22. 22 Risch N. Linkage strategies fur genetically complex trails: I. multi-locus models. Am J Med Gen 1990; 46: 222-228.
23. 23 Coryell W, Winokur G, Shea T, Maser J, Endicott J, Akiskal H. The long-term stability of depressive subtypes. Am J Psychiatry 1994; 151: 199-204.
24. 24 Barbujani G, Sokal RR. Genetic population structure of Italy. I. Geographic patterns of gene frequencies. Hum Biol 1991; 63: 253-272.
25. 25 Gasparini P, Estivill X, Volpini V, Totaro A, Castellvi-Bel S, Govea N et al. Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families. Eur J Hum Genet 1997; 5: 83-88.
26. 26 Fuciarelli M, Vienna A, Paba E, Bastianini A, Sansonetti B, Capucci E et al. PI, GC, HP, and TF serum protein polymorphisms in Siena, Tuscany, Italy, with a review of data for Italy. Am J Hum Biol 1997; 9: 629-646.
27. 27 Carey G. Genetic association study in psychiatry: analytical evaluation and a recommendation. Am J Med Gen 1994; 54: 311-317.
28. 28 Levinson D. Pragmatics and statistics in psychiatric genetics. Am J Med Gen 1997; 74: 220-222.
29. 29 Endicott J, Spitzer R. A diagnostic interview: the schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 1978; 35: 837-844.
30. 30 American Psychiatric Asssociation. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington DC, 1994.
31. 31 Lahiri D, Nurnberger JJ. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Res 1991; 19: 5444.
32. 32 Bech P, Malt U, Dencker S, Ahlfors U, Elgen K, Lewander T et al. Scales for assessment of diagnosis and severity of mental disorders. Acta Psychiatr Scond 1993; 87 (Suppl 372): 37-40.
33. 33 Bellini L, Gatti F, Gasperini M, Smeraldi E. A comparison between delusional and non-delusional depressives. J Affect Disord 1992; 25: 129-138.
34. 34 Lattuada E, Serretti A, Cusin G, Gasperini M, Macciardi F, Smeraldi E. Symptomatologic analysis of psychotic and non-psychotic depression. J Affect Disord (in press).
35. 35 Serretti A, Lattuada E, Cusin C, Macciardi F, Smeraldi E. Analysis of depressive symptomatology in mood disorders. Depress Anxiety 1998; 8: 80-85.
36. 36 Serretti A, Jori MC, Casodei G, Ravizza L, Smeraldi E, Akiskal H, Delineating psychopathologic clusters within dysthymia: a study of 512 patients. J Affect Disord (in press).
37. 37 Sobin CA, Sackeim H. Psychomotor symptoms of depression. Am J Psychiatry 1997; 154: 4-17.