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Volumn 121, Issue 24, 1999, Pages 5829-5830

A rationally designed inhibitor of α-1,3-galactosyltransferase

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE INHIBITOR; ENZYME INHIBITOR; GALACTOSYLTRANSFERASE; UNCLASSIFIED DRUG;

EID: 0001165445     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9905391     Document Type: Article
Times cited : (40)

References (36)
  • 5
    • 0020714288 scopus 로고
    • (a) Bause, E. Biochem. J. 1983, 209, 323-330.
    • (1983) Biochem. J. , vol.209 , pp. 323-330
    • Bause, E.1
  • 21
    • 0345630662 scopus 로고    scopus 로고
    • note
    • This type of "two-step double-displacement transfer mechanism" has been proposed by Lowary and Hindsgaul for other α-glycosyltransferases, see: ref 2b.
  • 23
    • 11944256494 scopus 로고
    • (b) Sinnot, M. L. Chem Rev. 1990, 90, 1171-1202.
    • (1990) Chem Rev. , vol.90 , pp. 1171-1202
    • Sinnot, M.L.1
  • 27
    • 0345630661 scopus 로고    scopus 로고
    • note
    • In the present study we used a recombinant porcine α-1,3-galacto-syltransferase obtained from Calbiochem (San Diego, CA). The inhibition assay was carried out as described in ref 12, except for the use of pH 7.0 and LacNAc as the acceptor.
  • 28
    • 0345630659 scopus 로고    scopus 로고
    • note
    • Synthesis of compounds 1, 4, 5, and 6 is described in Supporting Information.
  • 31
    • 0345630658 scopus 로고    scopus 로고
    • note
    • When a 5′-thio derivative of uridine was subjected to the coupling reaction with a tosyl derivative of the threiol, only a small amount of the coupling product was obtained, probably because of the competing intramolecular cyclization of the thio moiety to the uracil group.
  • 34
    • 0344768124 scopus 로고    scopus 로고
    • note
    • i of 13 μM, see: ref 12.
  • 36
    • 0345198682 scopus 로고    scopus 로고
    • John Wiley & Sons: New York, Chapter 4. See also Supporting Information
    • Segel, I. H. Enzyme Kinetics; John Wiley & Sons: New York, 1973; Chapter 4. See also Supporting Information.
    • Enzyme Kinetics , pp. 1973
    • Segel, I.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.