An IL-7 fusion protein that shows increased thymopoietic ability

Journal of Immunology

Volumn 175, Issue 6, 2005, Pages 4112-4118

  Henson, Sian M ^a,d   Snelgrove, Robert ^b   Hussell, Tracy ^b   Wells, Dominic J ^c   Aspinall, Richard ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR9; HYBRID PROTEIN; INTERLEUKIN 7;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; INFLUENZA VIRUS; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE; THYMOPOIESIS; THYMUS; VIRUS LOAD;

EID: 24744434924     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.6.4112     Document Type: Article

References (43)

1. Molineux, G. 2002. Pegylation: engineering improved pharmaceuticals for enhanced therapy. Cancer Treat. Rev. 28 (Suppl. A): 13-16.
2. Osborn, B. L., H. S. Olsen, B. Nardelli, J. H. Murray, J. X. Zhou, A. Garcia, G. Moody, L. S. Zaritskaya, and C. Sung. 2002. Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-a fusion protein in cynomolgus monkeys. J. Pharmacol. Exp. Ther. 303: 540-548.
3. + T lymphocytes in naive and simian immunodeficiency virus-infected rhesus monkeys. AIDS Res. Hum. Retroviruses 17: 873-886.
4. Savage, P., A. So, R. A. Spooner, and A. A. Epenetos. 1993. A recombinant single-chain antibody interleukin-2 fusion protein. Cell Biophys. 22: 61-77.
5. Moore, N. C., G. Anderson, C. A. Smith, J. J. Owen, and E. J. Jenkinson. 1993. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur. J. Immunol, 23: 922-927.
6. Oosterwegel, M. A., M. C. Haks, U. Jeffry, R. Murray, and A. M. Kruisbeek. 1997. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Immunity 6: 351-360.
7. Fry, T. J., B. L. Christensen, K. L. Komschlies, R. E. Gress, and C. L. Mackall. 2001. Interleukin-7 restores immunity in athymic T-cell-depleted hosts. Blood 97: 1525-1533.
8. Andrew, D., and R. Aspinall. 2001. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J. Immunol. 166: 1524-1530.
9. Bolotin, E., M. Smogorzewska, S. Smith, M. Widmer, and K. Weinberg. 1996. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 88: 1887-1894.
10. Fry, T. J., and C. L. Mackall. 2002. Interleukin-7 and immunorestoration in HIV: beyond the thymus. J. Hematother. Stem Cell Res. 11: 803-807.
11. Toraldo, G., C. Roggia, W. P. Qian, R. Pacifici, and M. N. Weitzmann. 2003. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells. Proc. Natl. head. Sci. USA 100: 125-130.
12. Rich, B. E., J. Campos-Torres, R. I. Tepper, R. W. Moreadith, and P. Leder. 1993. Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice. J. Exp. Med. 177: 305-316.
13. Storek, J., T. Gillespy III, H. Lu, A. Joseph, M. A. Dawson, M. Gough, J. Morris, R. C. Hackman, P. A. Horn, G. E. Sale, et al. 2003. Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys. Blood 101: 4209-4218.
14. El Kassar, N., P. J. Lucas, D. B. Klug, M. Zamisch, M. Merchant, C. V. Bare, B. Choudhury, S. O. Sharrow, E. Richie, C. L. Mackall, and R. E. Gress. 2004. A dose effect of IL-7 on thymocyte development. Blood 104: 1419-1427.
15. Phillips, J. A., T. I. Brondstetter, C. A. English, H. E. Lee, E. L. Virts, and M. L. Thoman. 2004. IL-7 gene therapy in aging restores early thymopoiesis without reversing involution. J. Immunol. 173: 4867-4874.
16. Youn, B. S., C. H. Kim, F. O. Smith, and H. E. Broxmeyer. 1999. TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. Blood 94: 2533-2536.
17. Zaballos, A., J. Gutierrez, R. Varona, C. Ardavin, and G. Marquez. 1999. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. 162: 5671-5675.
18. Andrew, D., and R. Aspinall. 2002. Age-associated thymic atrophy is linked to a decline in 1L-7 production. Exp. Gerontol. 37: 455-463.
19. Dong, Y., A. I. Skoultchi, and J. W. Pollard. 1993. Efficient DNA transfection of quiescent mammalian cells using poly-L-ornithine. Nucleic Acids Res. 21: 771-772.
20. McMahon, J. M., E. Signori, K. E. Wells, V. M. Fazio, and D. J. Wells. 2001. Optimization of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase; increased expression with reduced muscle damage. Gene Ther. 8: 1264-1270.
21. Gollins, H., J. McMahon, K. E. Wells, and D. S. Wells. 2003. High-efficiency plasmid gene transfer into dystrophic muscle. Gene Ther. 10: 504-512.
22. Pido-Lopez, J., N. Imami, D. Andrew, and R. Aspinall. 2002. Molecular quantitation of thymic output in mice and the effect of IL-7. Eur. J. Immunol 32: 2827-2836.
23. - thymocyte population. Cell. Immunol. 212: 150-157.
24. Humphreys, I. R., G. Walzl, L. Edwards, A. Rae, S. Hill, and T. Hussell. 2003. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. J. Exp. Med. 198: 1237-1242.
25. Durieux, A. C., R. Bonnefoy, T. Busso, and D. Freyssenet. 2004. In vivo gene electrotransfer into skeletal muscle: effects of plasmid DNA on the occurrence and extent of muscle damage. J. Gene Med. 6: 809-816.
26. Bui, T., C. Faltynek, and R. J. Ho. 1994. Differential disposition of soluble and liposome-formulated human recombinant interleukin-7: effects on blood lymphocyte population in guinea pigs. Pharm. Res. 11: 633-641.
27. Hussell, T., A. Pennycook, and P. J. Openshaw. 2001. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur. J. Immunol 31: 2566-2573.
28. Swain, S. L., R. W. Dutton, and D. L. Woodland. 2004. T cell responses to influenza virus infection: effector and memory cells. Viral Immunol 17: 197-209.
29. Hannoun, C., F. Megas, and J. Piercy. 2004. Immunogenicity and protective efficacy of influenza vaccination. Virus Res. 103: 133-138.
30. Abdul-Hai, A., A. Ben Yehuda, L. Weiss, G. Friedman, Z. Zakay-Rones, S. Slavin, and R. Or. 1997. Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice. Bone Marrow Transplant. 19: 539-543.
31. Wiryana, P., T. Bui, C. R. Faltynek, and R. J. Ho. 1997. Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells. Vaccine 15: 561-563.
32. Haynes, L., S. M. Eaton, E. M. Burns, T. D. Randall, and S. L. Swain. 2003. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc. Natl head. Sci. USA 100: 15053-15058.
33. + T lymphocytes during primary influenza infection. Mech. Ageing Dev. 123: 1167-1181.
34. + T cell responses to influenza vaccine. J. Immunol. 173: 673-681.
35. Haynes, L., S. M. Eaton, E. M. Burns, T. D. Randall, and S. L. Swain. 2005. Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J. Exp. Med. 201: 845-851.
36. Gershon, S. K., H. Luksenburg, T. R. Cote, and M. M. Braun. 2002. Pure red-cell aplasia and recombinant erythropoietin. N. Engl. J. Med. 346: 1584-1586.
37. Lacroix-Desmazes, S., N. Misra, J. Bayry, D. Mohanty, S. V. Kaveri, and M. D. Kazatchkine. 2002. Autoantibodies to factor VIII, Autoimmun. Rev. 1: 105-110.
38. Massa, G., M. Vanderschueren-Lodeweyckx, and R. Bouillon. 1993. Five-year follow-up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone. Clin. Endocrinol. 38: 137-142.
39. Gribben, J, G., S. Devereux, N. S. Thomas, M. Keim, H. M. Jones, A. H. Goldstone, and D. C. Linch. 1990. Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF. Lancet 335: 434-437.
40. Leroy, V., J. Arvieux, M. C. Jacob, M. Maynard-Muet, M. Baud, and J. P. Zarski. 1998. Prevalence and significance of anticardiolipin, anti-β2 glycoprotein I and anti-prothrombin antibodies in chronic hepatitis C. Br. J. Haematol. 101: 468-474.
41. Deisenhammer, F., I. Mayringer, J. Harvey, E. Dilitz, T. Gasse, D, Stadlbauer, M. Reindl, and T. Berger. 2000. A comparative study of the relative bioavailability of different interferon β preparations. Neurology 54: 2055-2060.
42. Lundin, K., L. Berger, F. Blomberg, and P. Wilton. 1991. Development of anti-hGH antibodies during therapy with authentic human growth hormone. Acta Paediatr. Scand. Suppl 372: 167-168.
43. Rudensky, A. Y., P. Preston-Hurlburt, S. C. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353: 622-627.