Antiulcerogenic effect of a hydroalcoholic extract and its organic fractions of Neurolaena lobata (L.) R.BR.

Phytomedicine

Volumn 7, Issue 4, 2000, Pages 283-289

  Gracioso, J S ^a   Hiruma Lima, C A ^b   Souza Brito, A R M ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Inst de Biologia e Saúde Pública   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROFORM; HEXANE; PLANT EXTRACT; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HERBAL MEDICINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; STOMACH ACID SECRETION; STOMACH MUCUS; STOMACH PAIN; STOMACH ULCER;

ANIMALIA; LOBATA; NEUROLAENA LOBATA;

EID: 0033862466     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0944-7113(00)80045-8     Document Type: Article

References (17)

1. Bolton, J.P., Palmer, D., Cohen, M.: Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandin. Digest. Diseases 23: 359-364, 1978.
2. Curtis, G.M., MacNaughton, W.K., Grant Gall, D., Wallace, J.L.: Intraluminal pH modulates gastric prostaglandin synthesis. Can J. Physiol. Pharmacol. 73: 130-134, 1995.
3. Droy-Lefaix, M.T.: Prostaglandins. In: Biology and Chemistry of Prostaglandins and Related Eicosanoids. (P.B.Curtis-Prior, ed.), pp. 345-360. Churchill Livingstone, New York, 1988.
4. Germosén-Robineau, L.: Investigación científica y uso popular de plantas medicinales en el Caribe. pp. 420-424. Farmacopea Caribeña. ed. Enda-Caribe, Tramil-7, Caribe, 1995.
5. Goa, K.L., Monk, J.P.: Emprostil: A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of peptic ulcer disease. Drugs 3: 539-559, 1987.
6. Gracioso, J.S., Hiruma-Lima, C.A., Paulo, M.Q., Souza-Brito, A.R.M.: Antinociceptive effect of the hydroalcoholic extract and organic fractions of N. lobata (L.) R.Br. in mice. J. Pharm. Pharmacol. 50:1-6, 1998.
7. Levine, R.J.: A method for rapid production of stress ulcers in rats. In: Peptic Ulcer. (C.J. Pfeiffer, ed.), pp. 92-97, Munksgaard, Copenhagen, 1971.
8. Mizui, T., Doteuchi, M.: Effect of polyamines on acidified ethanol-induced gastric lesion in rats. Japan. J. Pharmacol. 33: 939-945, 1983.
9. Morimoto, Y., Shimohara, K., Oshima, S., Sukamoto, T.: Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine. Japan. J. Pharmacol. 57: 595-505, 1991.
10. Pasrreiter, C. M.: Sesquiterpene lactones from N. lobata. Phytochemistry. 39:133-137, 1995.
11. Rainsford, K. D.: Gastric ulcerogenicity of non-steroidal anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. J. Pharm. Pharmacol. 39: 669-672, 1978.
12. Shay, H., Komarov, S.A., Pels, S.S., Meranze, D., Gruenstein, M., Siplet, H.: A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 5:43-61, 1945.
13. Souza Brito, A.R.M. Rodríguez, J.A., Hiruma-Lima, C.A., Haun, M., Nunes, D.S.: Antiulcerogenic activity of transdehydrocrotonin from Croton cajucara. Planta Med. 64:126-129, 1998.
14. Stein, T.A.; Keegan L.M.; Auguste, L.; Bailey, B.; Wise, L.: Stress-induced gastric lesions and the synthesis of prostaglandins and leukotrienes. J. Surgical Research 51: 368-371, 1991.
15. Sun, S.B., Matsumoto, T., Yamada, H.: Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer models in rats and mice. J. Pharm. Pharmacol. 43: 699-704, 1991.
16. Szabo, S.: Mechanisms of mucosal injury in the stomach and duodenum: Time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand. J. Gastroenterol. 22 (Supp. 127): 21-28, 1987.
17. 2 content, mucus gel thickness, and experimental ulcers in the stomach of developing rats. Digestion 57:47-53, 1996.