Clotrimazole inhibits hemoperoxidase of Plasmodium falciparum and induces oxidative stress: Proposed antimalarial mechanism of clotrimazole

Journal of Biological Chemistry

Volumn 280, Issue 50, 2005, Pages 41129-41136

  Trivedi, Vishal ^a,b   Chand, Prem ^b   Srivastava, Kumkum ^a   Puri, Sunil K ^a   Maulik, Prakas R ^a   Bandyopadhyay, Uday ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; GROWTH KINETICS; MICROORGANISMS; OXIDATION; PARAMAGNETIC RESONANCE; STRESS ANALYSIS;

HEMOPEROXIDASE; PARASITE GROWTH; PLASMODIUM FALCIPARUM; PSEUDO-FIRST ORDER KINETICS;

ENZYMES;

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CLOTRIMAZOLE; HEME; HEMOPEROXIDASE; HYDROGEN PEROXIDE; NITROGEN; PEROXIDASE; RADICAL; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALARIA; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, PROTOZOAN; ANTIMALARIALS; CATALYSIS; CLOTRIMAZOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; FREE RADICALS; GLUTATHIONE; GROWTH INHIBITORS; HEME; HEMEPROTEINS; HYDROGEN PEROXIDE; KINETICS; LIPID PEROXIDATION; MASS SPECTROMETRY; MODELS, CHEMICAL; NITROGEN; OXIDATIVE STRESS; OXYGEN; PEROXIDASES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; TIME FACTORS;

PLASMODIUM FALCIPARUM;

EID: 24644438428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M501563200     Document Type: Article

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