Effect of antifungal azoles on the heme detoxification system of malarial parasite

Journal of Biochemistry

Volumn 131, Issue 3, 2002, Pages 437-444

  Huy, Nguyen Tien ^a   Kamei, Kaeko ^a   Kondo, Yoshiro ^a   Serada, Satoshi ^a   Kanaori, Kenji ^a   Takano, Ryo ^a   Tajima, Kunihiko ^a   Hara, Saburo ^a  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Antifungal azoles; Antimalarial; ESR; Heme; Malaria

Indexed keywords

ANTIFUNGAL AGENT; CLOTRIMAZOLE; GLUTATHIONE; HEME; HISTIDINE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; MICONAZOLE; PEPTIDE DERIVATIVE; PYRROLE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CATABOLISM; COMPLEX FORMATION; DETOXIFICATION; DRUG EFFECT; HEMOLYSIS; HUMAN; HUMAN CELL; NONHUMAN; PLASMODIUM; POLYMERIZATION; PROTEIN DEGRADATION;

ANIMALS; ANTIFUNGAL AGENTS; ANTIMALARIALS; CLOTRIMAZOLE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ERYTHROCYTES; GLUTATHIONE; HEME; HEMOLYSIS; HUMANS; KETOCONAZOLE; MICONAZOLE; PEPTIDES; PLASMODIUM FALCIPARUM; SPECTRUM ANALYSIS;

PROTOZOA;

EID: 0036220122     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003119     Document Type: Article

References (45)

1. Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications
2. The interaction of hemin and bilirubin with the human red cell membrane
3. The antimalarial drug, chloroquine, interacts with lactate dehydrogenase from Plasmodium falciparum
4. Inhibition of bovine lens glutathione S-transferases by hematin, bilirubin, and bromosulfophthalein
5. Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum
6. Plasmodium hemozoin formation mediated by histidine-rich proteins
7. Kinetics of the interaction of hemin liposomes with heme binding proteins
8. Heme transfer between phospholipid membranes and uptake by apohemoglobin
9. The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity Biochim
10. Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers
11. Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells
12. Clotrimazole binds to heme and enhances heme-dependent hemolysis: Proposed antimalarial mechanism of clotrimazole
13. Glutathione as a scavenger of free hemin. A mechanism of preventing red cell membrane damage
14. The malaria parasite supplies glutathione to its host cell - Investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum
15. Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione
16. An intergrated model of chloroquine action
17. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
18. Imidazole and polyene activity against chloroquine-resistant Plasmodium falciparum
19. Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates
20. Oxygen enhances the antimalarial activity of the imidazoles
21. Clotrimazole inhibits the growth of Plasmodium falciparum in vitro
22. Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum
23. Clotrimazole inhibits cell proliferation in vitro and in vivo
24. 2+ pump in Plasmodium falciparum-infected human red blood cells
25. 2+ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole
26. Accumulation and drainage of hemin in the red cell membrane
27. Binding of imidazole and 2-methylimidazole by hemes in organic solvents. Evidence for five-coordination
28. Spectral and interferometrical study of the interaction of haemin with glutathione
29. Iron ligands in different forms of ferricytochrome c: The 620-nm band as a probe
30. Kinetics and thermodynamics of the reactions of two iron (III) porphyrins with imidazole and 1-methylimidazole in dimethyl sulfoxide
31. Axial ligands of chloroplast cytochrome b-559: Identification and requirement for a heme-cross-linked polypeptide structure
32. Spectroscopic characterization of the hemebinding sites in Plasmodium falciparum histidine-rich protein 2
33. A spectroscopic study of the haemin-human-serum-albumin system
34. Studies on haemin in dimethyl sulphoxide/water mixtures
35. Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX
36. The physical chemistry of hemes and hemopeptides. I. Physiochemical properties and reduction of chlorodeuterohemin in organic solvent
37. A possible model of a hemoprotein-hydrogen peroxide complex
38. EPR spectrocopy: A powerful technique for the structural and functional investigation of metalloproteins
39. Analysis of low-spin ESR spectra of ferric heme proteins: A reexamination
40. High-performance liquid chromatographic analysis for the determination of miconazole in human plasma using solid-phase extraction
41. + channel: The imidazole ring is not required for inhibitory activity
42. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease
43. Treatment of coccidioidomycosis with ketoconazole: Clinical and laboratory studies of 18 patients