The tumorigenic characteristics of Lime-Piper betel quid-transformed JB6 cells

Archives of Toxicology

Volumn 78, Issue 3, 2004, Pages 167-173

  Lin, Ming Hsun ^a   Wang, Chau Jong ^a   Huang, Hui Pei ^a   Chou, Ming Yung ^a   Chou, Fen Pi ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Lime piper betel quid; Oncogenic; Promotion effect; Proto oncogene

Indexed keywords

AGAR; BETEL EXTRACT; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENIC ACTIVITY; CELL CYCLE S PHASE; CELL POPULATION; CELL TRANSFORMATION; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH RATE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN INDUCTION;

ALKALOIDS; ARECA; BLOTTING, WESTERN; CALCIUM COMPOUNDS; CARCINOGENS; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CITRUS AURANTIIFOLIA; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; MASTICATION; OXIDES; PIPER; PIPERACEAE; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; S PHASE; TAIWAN; TIME FACTORS;

NICOTIANA TABACUM; PIPER BETEL;

EID: 2442713819     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0524-1     Document Type: Article

References (51)

1. Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochimo Biophy Acta 1072:129-157
2. Arnold JT, Wilkinson BP, Sharma S, Steele VE (1995) Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay. Cancer Res 55:537-543
3. Beier R, Burgin A, Kiermaier A, Fero M, Karsunky H, Saffrich R, Moroy T, Ansorge W, Roberts J, Eilers M (2000) Inductiomn of cyclin E-cdk 2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events. EMBO J 19:5813-5823
4. Bernstein LR, Colburn NH (1989) AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 244:566-569
5. Boxer LM, Dang CV (2001) Translocations involving c-myc and c-myc function. Oncogene 20:5595-5610
6. Cohen SM, Ellwein LB (1991) Genetic errors, cell proliferation and carcinogenesis. Cancer Res 51:6493-6495
7. Colburn NH, Koehler BA, Nelson KJ (1980) A cell culture assay for tumor-promoter-dependent progression toward phenotype: detection of tumor promoters and promotion inhibitors. Terato Carcino Muta 1:87-96
8. Dave BJ, Trivedi AH, Adhvaryu SG (1992) In vitro genotoxic effects of areca nut extract and arecoline. J Cancer Res Clin Oncol 118:283-288
9. Devary Y, Gottlieb RA, Lau LF, Karin M (1991) Rapid and preferential activation of the c-jun gene during the mammalian UV response. Molecu Cellu Biol 1:2804-2811
10. Devary Y, Gottlieb RA, Smeal T, Karin M (1992) The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081-1091
11. Frazelle JH, Abernethy DJ, Boreiko CJ (1983) Factors influencing the promotion of transformation in chemically-initiated C3H10T1/2 C18 mouse embryo fibroblasts. Carcinogenesis 4:709-715
12. Freedman V, Shin SI (1974) Cellular tumorigenicity in nude mice correlation with cell growth in semi-solid medium. Cell 3:355-359
13. Guengerich FP (2000) Metabolism of chemical carcinogens. Carcinogenesis 21:345-351
14. Herschman HR (1991) Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281-319
15. Hoffmann D, Brunnemann KD, Prokopczyk B, Djordjevic MV (1994) Tobacco-specific H-nitrosamines and areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans. J Toxicol Environ Health 41:1-52
16. Huang C, Ma WY, Hecht SS, Dong Z (1997) Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3′ kinase. Cancer Res 57:2873-2878
17. Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM (1999) Mechanism-based cancer prevention approaches: targets, examples and the use of transgenic mice. J Natl Cancer Inst 91:215-225
18. IARC (1985) Betel-quid and areca-nut chewing. In: Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 37. Habits other than of smoking. International Agency for Research on Cancer, Lyon, pp. 141-202
19. Ince H, Monte SM, Wands JR (2000) Overexpression of human aspartyl (asparginyl) β-hydroxylase is associated with malignant transformation. Cancer Res 60:1261-1266
20. Jayant K, Balakrishnan V, Sanghvi LD (1977) Quantification of the role of smoking and chewing tobacco in oral, pharyngeal and oesophageal cancer. Brit J Cancer 35:232-235
21. Jeng JH, Kuo ML, Hahn LJ, Kuo MYP (1994) Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. J Dental Res 73:1043-1049
22. Jin YT, Tsai ST, Wong TY, Chen FF, Chen RMY (1996) Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis. Oral Oncol Europ J Cancer 32(B):343-346
23. Karin M, Liu Z, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240-246
24. Kehrer JP (1993) Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48
25. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC (1995) Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 24:450-453
26. Lee MJ, Hsu JD, Lin CL, Lin MH, Yuan SC, Wang CJ (2002) Induction of epidermal proliferation and expressions of PKC and NF-kappaB by betel quid extracts in mouse: the role of lime-piper additives in betel quid. Chem Biol Interact 140:35-48
27. Lin MH, Chou FP, Huang HP, Hsu JD, Chou MY, Wang CJ (2003) The tumor promoting effect of lime-piper betel quid in JB6 cells. Food Chem Toxicol (in press)
28. Liu Y, Egyhazi S, Hansson J, Bhide SV, Kulkarni PS, Grafstrom RC (1997) o6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro. Carcinogenesis 18:1889-1895
29. Lu YP, Chang RL, Lou YR, Huang MT, Newmark HL, Reuhl KR, Conney AH (1994) Effect of curcumin on 12-o-tetradecanoylphorbol- 13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis 15:2363-2370
30. MacDonald DG (1987) Effect of arecaidine application to hamster cheek pouch. J Oral Med 42:61-62
31. Manome Y, Datta R, Fine HA (1993) Early response gene induction following DNA damage in astrocytoma cell lines. Biochem Pharmaco 45:1677-1684
32. Marnett LJ (2000) Oxyradicals and DNA damage. Carcinogenesis 21:361-370
33. Medvedev AE, Blanco JCG, Quershi N, Vogel SN (1999) Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. J Biol Chem 14:9342-9350
34. Mondal S, Branlow DW, Heidelberger C (1976) Two-stage chemical oncogenesis in cultures of C3H10T1/2 cells. Cancer Res 36:2254-2260
35. Nose K, Shibanuma M, Kikuchi K, Kageyama H, Sakiyama S, Kuroki T (1991) Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Euro J Biochem 201:99-106
36. Piechaczyk M, Blanchard JM (1994) c-Fos proto-oncogene regulation and function. Crit Rev Oncol Hematol 17:93-131
37. Ransone LJ, Verma IM (1990) Nuclear proto-oncogenes fos and jun. Annu Rev Cell Biol 6:539-557
38. Reznikoff CA, Bertram JS, Brankow DW, Heidelberger C (1973) Quantitative and qualitative studies if chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Res 33:3239-3249
39. Rohn JL, Hueber AO, McCarthy NJ, Lyon D, Navarro P, Burgering BM, Evan GI (1998) The opposing roles of the Akt and c-Myc signaling pathways in survival from CD95-mediated apoptosis. Oncogene 17:2811-2818
40. Roussel MF (1998) Key effectors of signal transduction and G1 progression. Adv Cancer Res 74:1-24
41. Schuhmacher M, Staege MS, Pajic A, Polack A, Weidle UH, Bornkamm GW, Eick D, Kohlhuber F (1999) Control of cell growth by c-Myc in the absence of cell division. Curr Biol 9:1255-1258
42. Sen S, Talukder G, Sharma A (1989) Betel cytotoxicity. J Ethnopharmacol 26:217-247
43. Sharan RN (1996) Association of betel nut with carcinogenesis. Cancer J 9:13-19
44. Sharan RN, Wary KK (1992) Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro. Mutat Res 278:271-276
45. Spencer CA, Groudine M (1991) Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res 56:1-48
46. Wang CK, Peng CH (1996) The mutagenicities of alkaloids and N-nitrosoguvacoline from betel quid. Mutat Res 360:165-171
47. Wary KK, Sharan RN (1988) Aqueous extract of betel-nut of North-East India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. J Cancer Res Clin Oncol 114:579-582
48. Weinstein IB (1988) The origin of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment. Cancer Res 48:4135-4143
49. Winn DM, Zeigler RG, Pickle LW, Gridley G, Blot WJ, Hoover RN (1984) Diet in the etiology of oral and pharyngeal cancer among women from the Southern United States. Cancer Res 44:1216-1222
50. Wisdom R (1999) AP-1: one switch for many signals. Exp Cell Res 253:180-185
51. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12:2424-2433