The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4

Journal of Biological Chemistry

Volumn 279, Issue 20, 2004, Pages 20950-20958

  Goruppi, Sandro ^a   Kyriakis, John M ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CELLS; DISEASES; PATHOLOGY; RNA;

PROTEIN KINASE; RENAL MESANGIAL CELL HYPERTROPHY;

PROTEINS;

ADVANCED GLYCATION END PRODUCT; BASIC HELIX LOOP HELIX PROTEIN P8; ENDOTHELIN; GLYCOGEN SYNTHASE KINASE 3; HELIX LOOP HELIX PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN KINASE B; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT 4; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME DEGRADATION; ENZYME INDUCTION; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HYPERGLYCEMIA; HYPERTROPHY; KIDNEY DISEASE; MESANGIUM CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CULTURE TECHNIQUES; CYSTEINE ENDOPEPTIDASES; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOTHELINS; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; GLYCOGEN SYNTHASE KINASE 3; HELIX-LOOP-HELIX MOTIFS; MULTIENZYME COMPLEXES; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NFATC TRANSCRIPTION FACTORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UBIQUITIN;

ANIMALIA;

EID: 2442675146     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312401200     Document Type: Article

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