Cleavage requirements for activation of factor V by factor Xa

European Journal of Biochemistry

Volumn 247, Issue 1, 1997, Pages 12-20

  Thorelli, Elisabeth ^a   Kaufman, Randal J ^b   Dahlbäck, Björn ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Activation; Factor V; Factor Xa; Recombinant; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; THROMBIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

EID: 0030805611     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00012.x     Document Type: Article

References (34)

1. Kane, W. H. & Davie, E. W. (1988) Blood coagulation factors V and VIII: Structural and functional similarities and their relationship to hemorrhagic and trombotic disorders, Blood 71, 539-555.
2. Jenny, R. J., Tracy, P. B. & Mann, K. G. (1994) The physiology and biochemistry of factor V. in Haemostasis and Thrombosis (Bloom, A. L., Forbes, C. D., Thomas, D. P. & Tuddenham, K. G. D., eds) pp. 465-476, Churchill Livingstone, Edinburgh.
3. Nesheim, M. H., Taswell, J. B. & Mann, K. G. (1979) The contribution of bovine factor V and factor Va to the activity of prothrombinase. J. Biol. Chem. 254, 10952-10962.
4. Jenny, R. J., Pittman, D. D., Toole, J. J., Kriz, R. W., Aldape, R. A., Hewick, R. M., Kaufman, R. J. & Mann, K. G. (1987) Complete cDNA and derived amino acid sequence of human factor V. Proc. Natl Acad. Sci. USA 84, 4846-4850.
5. Esmon, C. T. (1979) The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits. and reconstitution of biological activity. J. Biol. Chem. 254, 964-973.
6. Nesheim, M. E. & Mann, K. G. (1979) Thrombin-catalyzed activation of single chain bovine factor V. J. Biol. Chem. 254, 1326-1334.
7. Suzuki, K., Dahlbäck, B. & Stenflo, J. (1982) Thrombin-catalyzed activation of human coagulation factor V, J. Biol. Chem. 257, 6556-6564.
8. Krishnaswamy, S. & Mann, K. G. (1988) The binding of factor Va to phospholipid vesicles. J. Biol. Chem. 263, 5714-5723.
9. Kalafatis, M., Jenny, R. J. & Mann, K. G. (1990) Identification and charactcrization of a phospholipid-binding site of bovine factor Va. J. Biol. Chem. 265, 21580-21589.
10. Ortel, T. L., Devore-Carter, D., Quinn-Allen, M. A. & Kane, W. H. (1992) Deletion analysis of recombinant human factor V. J. Biol. Chem. 267, 4189-4198.
11. Ortel, T. L., Quinn-Allen, M. A., Keller, F. G., Peterson, J. A., Larocca, D. & Kane W. H. (1994) Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras, J. Biol. Chem. 269, 15898-15905.
12. Guinto, E. R. & Esmon, C. T. (1984) Loss of prothrombin and factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C. J. Biol. Chem. 259, 13986-13992.
13. Tucker, M. M., Foster, W. B., Katzmann, J. A. & Mann, K. G. (1983) A monoclonal antibody which inhibits the factor Va:factor Xa interaction, J. Biol. Chem. 258, 1210-1214.
14. Bakker, H. M., Tans, G., Christella, M., Thomassen, L. G. D., Yukelson, L. Y., Ebberink, R., Hemker, H. C. & Rosing, J. (1994) Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain. J. Biol. Chem. 269, 20662-20667.
15. Keller, F. G., Ortel, T. L. & Kane, W. H. (1995) Thrombin-catalyzed activation of recombinant human factor V. Biochemistry 34, 4118-4124.
16. Kane, W. H. & Majcrus, P. W. (1981) Purification and characterization of human coagulation factor V. J. Biol. Chem. 256, 1002 1007.
17. Moncovic, D. D. & Tracy, P. B. (1990) Activation of human factor V by factor Xa and thrombin. Biochemistry 29, 1118-1128.
18. Moncovic, D. D. & Tracy, P. B. (1990) Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin. J. Biol. Chem. 265, 17132-17140.
19. Foster, W. B., Nesheim, M. E. & Mann, K. G. (1983) The factor Xa-catalyzed activation of factor V. J. Biol. Chem. 258, 13970-13977.
20. Dahlbäck, B. & Stenflo, J. (1978) Binding of bovine coagulation factor Xa to platelets. Biochemistry 17, 4938-4945.
21. Suzuki, K., Slenflo, J., Dahlhäck, B., Teodorsson, B. (1983) Inactivation of human coagulation factor V by activated protein C. J. Biol. Chem. 258, 1914-1920.
22. Esmon, C. T. & Jackson, C. M. (1973) The factor V activating enzyme of Russell's viper venom, Thromb. Res. 2, 509-524.
23. Dahlbäck, B. (1980) Human coagulation factor V purification and thrombin-catalyzed activation. J. Clin. Invest. 66, 583-591.
24. Stenflo, J. (1976) A new vitamin K-dependent protein. J. Biol. Chem. 251, 355-363.
25. Marquette, K. A., Pittman, D. D. & Kaufman, R. J. (1995) The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain. Blood 86, 3026-3034.
26. Kaufman, R. J. (1990) Vectors used for expression in mammalian cells. Methods Enzymol. 185, 487-511.
27. Matsudaira, P. (1987) Sequence from picomole quantities of proteins electroblolted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262, 10035-10038.
28. Wencel-Drake, J. D., Dahlbäck, B. & Ginsburg, M. H. (1986) Ultrastructural localization of coagulation factor V in human platelets. Blood 68, 244-249.
29. Omar, M. N. & Mann, K. G. (1987) Inactivation of factor Va by plasmin. J. Biol. Chem. 262, 9750-9755.
30. Odegaard, B. & Mann, K. G. (1987) Proteolysis of factor Va by factor Xa and activated protein C. J. Biol. Chem. 262, 11233-11 238.
31. Guinto, H. R., Esmon, C. T. Mann, K. G. & MacGillivray, R. T. A. (1992) The complete cDNA sequence of bovine coagulation factor V. J. Biol. Chem. 267, 2971-2978.
32. Eaton, D., Rodriguez, H. & Vehar, G. A. (1986) Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa. and activated protein C with activation and inactivation of factor VIII coagulant activity. Biochemistry 25, 505-512.
33. Donath, M. J. S. H., Lenting, P. J., van Mourik, J. A. & Mertens, K. (1995) The role of cleavage of the light chain at positions Arg1689 or Arg1721 in subunit interaction and activation of human blood coagulation factor VIII, J. Biol. Chem. 270, 3648-3655.
34. Annamalai, A. H., Rao, A. K., Chiu, H. C., Wang, D., Dutta Roy, A. K., Walsh, P. N. & Colman, R. W. (1987) Epitope mapping of functional domains of human factor Va with human and murine monoclonal antibodies. Evidence for the interaction of heavy chain with factor Xa and calcium. Blood 70, 139-146.