Gene-targeting studies of the Renin-angiotensin system: Mechanisms of hypertension and cardiovascular disease

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 67, Issue , 2002, Pages 451-457

  Gurley, S B ^a   Le, T H ^a   Coffman, T M ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; RENIN; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN RECEPTOR; GLYCOPROTEIN;

BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; GENE TARGETING; HUMAN; HYPERTENSION; PATHOGENESIS; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; ARTICLE; CELL MEMBRANE; GENE EXPRESSION; GENE FUNCTION; GENETIC VARIABILITY; GENOMICS; JUXTAGLOMERULAR APPARATUS; KIDNEY; KIDNEY COLLECTING TUBULE; KIDNEY FUNCTION; NONHUMAN; PARTIAL NEPHRECTOMY; UPREGULATION;

EID: 0038801208     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2002.67.451     Document Type: Conference Paper

References (68)

1. 1 receptor antagonist. J. Biol. Chem. 276: 39721.
2. Agerholm-Larsen B., Nordestgaard B.G., Steffensen R., Sorensen T.I., Jensen G., and Tybjaerg-Hansen A. 1997. ACE gene polymorphism: Ischemic heart disease and longevity in 10,150 individuals. A case-reference and restrospective cohort study based on the Copenhagen City Heart Study. Circulation 95: 2358.
3. Asano K., Dutcher D.L., Port J.D., Minobe W.A., Tremmel K.D., Roden R.L., Bohlmeyer T.J., Bush E.W., Jenkin M.J., Abraham W.T., Raynolds M.V., Zisman L.S., Perryman M.B., and Bristow M.R. 1997. Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium (see comments) (erratum in Circulation [1997] 96: 4435). Circulation 95: 1193.
4. Beldent V., Michaud A., Wei L., Chauvet M.T., and Corvol P. 1993. Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site. J. Biol. Chem. 268: 26428.
5. Benetos A. and Safar M.E. 1996. Aortic collagen, aortic stiffness, and AT1 receptors in experimental and human hypertension. Can. J. Physiol. Pharmacol. 74: 862.
6. Bonnardeaux A., Davies E., Jeunemaitre X., Fery I., Charru A., Clauser E., Tiret L., Cambien F., Corvol P., and Soubrier F. 1994. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 24: 63.
7. Bronson S. and Smithies O. 1994. Altering mice by homologous recombination using embryonic stem cells. J. Biol. Chem. 269: 27155.
8. Burson J.M., Aguilera G., Gross K.W., and Sigmund C.D. 1994. Differential expression of angiotensin receptor 1A and 1B in mouse. Am. J. Physiol. 267: E260.
9. Cole J., Quach D.L., Sundaram K., Corvol P., Capecchi M.R., and Bernstein K.E. 2002. Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure. Circ. Res. 90: 87.
10. CONSENSUS Trial Study Group. 1987. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. N. Engl. J. Med. 316: 429.
11. Crackower M.A., Sarao R., Oudit G.Y., Yagil C., Kozieradzki I., Scanga S.E., Oliveira-dos-Santos A.J., da Costa J., Zhang L., Pei Y., Scholey J., Ferrario C.M., Manoukian A.S., Chappell M.C., Backx P.H., Yagil Y., and Penninger J.M. 2002. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822.
12. Davisson R.L., Oliverio M.I., Coffman T.M., and Sigmund C.D. 2000. Divergent functions of angiotensin II receptor isoforms in the brain. J. Clin. Invest. 106: 103.
13. Davisson R.L., Kim H.S., Krege J.H., Lager D.J., Smithies O., and Sigmund C.D. 1997. Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J. Clin. Invest. 99: 1258.
14. Dickinson D.P., Gross K.W., Piccini N., and Wilson C.M. 1984. Evolution and variation of renin genes in mice. Genetics 108: 651.
15. Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N., Donovan M., Woolf B., Robison K., Jeyaseelan R., Breitbart R.E., and Acton S. 2000. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 87: E1.
16. Doria A., Warram J.H., and Krolewshi A.S. 1994. Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I-converting enzyme gene. Diabetes 43: 690.
17. Esther C.R., Howard T.E., Marino E.M., Goddard J.M., Capecchi M.R., and Bernstein K.E. 1996. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab. Invest. 74: 953.
18. Esther C.R., Marino E.M., Howard T.E., Machaud A., Corvol P., Capecchi M.R., and Bernstein K.E. 1997. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J. Clin. Invest. 99: 2375.
19. Gasc J.M., Shanmugam S., Sibony M., and Corvol P. 1994. Tissue-specific expression of type I angiotensin II receptor subtypes. An in situ hybridization study. Hypertension 24: 531.
20. Gomez R.A., Lynch K.R., Chevalier R.L., Wilfong N., Everett A., Carey R.M., and Peach M.J. 1988a. Renin and angiotensinogen gene expression in maturing rat kidney. Am. J. Physiol. 254: F582.
21. Gomez R.A., Lynch K.R., Chevalier R.L., Everett A.D., Johns D.W., Wilfong N., Peach M.J., and Carey R.M. 1988b. Renin and angiotensinogen gene expression and intrarenal rennin during ACE inhibition. Am. J. Physiol. 254: F900.
22. Gordon J.W. and Ruddle F.H. 1981. Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 214: 1244.
23. Grady E.F., Sechi L.A., Griffin C.A., Schambelan M., and Kalinyak J.E. 1991. Expression of AT2 receptors in the developing rat fetus. J. Clin. Invest. 88: 921.
24. Haywood G.A., Gullestad L., Katsuya T., Hutchinson H.G., Pratt R.E., Horiuchi M., and Fowler M.B. 1997. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation 95: 1201.
25. Hein L., Barsh G.S., Pratt R.E., Dzau V.J., and Kobilka B.K. 1995. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice (erratum in Nature [1996] 380: 366). Nature 377: 744.
26. Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B.L., and Inagami T. 1995. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377: 748.
27. Ito M., Oliverio M.I., Mannon P.J., Best C.F., Maeda N., Smithies O., and Coffman T.M. 1995. Regulation of blood pressure by the type IA angiotensin II receptor gene. Proc. Natl. Acad. Sci. 92: 3521.
28. Jeunemaitre X., Soubrier F., Kotelevtsev Y.V., Lifton R.P., Williams C.S., Charru A., Hunt S.C., Hopkins P.N., Williams R.R., and Lalouel J.M., et al. 1992. Molecular basis of human hypertension: Role of angiotensinogen. Cell 71: 169.
29. Jones C.A., Sigmund C.D., McGowan R.A., Kane-Haas C.M., and Gross K.W. 1990. Expression of murine renin genes during fetal development. Mol. Endocrinol. 4: 375.
30. Kakuchi J., Ichiki T., Kiyama S., Hogan B.L., Fogo A., Inagami T., and Ichikawa I. 1995. Developmental expression of renal angiotensin II receptor genes in the mouse. Kidney Int. 47: 140.
31. Kario K., Kanai N., Nishiuma S., Fujii T., Saito K., Matsuo T., Matsuo M., and Shimada K. 1997. Hypertensive nephropathy and the gene for angiotensin-converting enzyme. Arterioscler. Thromb. Biol. 17: 252.
32. Kim H.S., Krege J.H., Kluckman K.D., Hagaman J.R., Hodgin J.B., Best C.F., Jennette J.C., Coffman T.M., Maeda N., and Smithies O. 1995. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. 92: 2735.
33. Krege J.H., Kim H.S., Moyer J.S., Jennette J.C., Peng L., Hiller S.K., and Smithies O. 1997. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 29: 150.
34. Krege J.H., John S.W., Langenbach L.L., Hodgin J.B., Hagaman J.R., Bachman E.S., Jennette J.C., O'Brien D.A., and Smithies O. 1995. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375: 146.
35. Lewis E.J., Hunsicker L.G., Bain R.P., and Rohde R.D. 1993. The effect of angiotensin-converting enzyme inhibitor on diabetic nephropathy. N. Engl. J. Med. 329: 1456.
36. Llorens-Cortes C., Greenberg B., Huang H., and Corvol P. 1994. Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis. Hypertension 24: 538.
37. Ludwig E., Corneli P.S., Anderson J.L., Marshall H.W., Lalouel J.M., and Ward R.H. 1995. Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis (see comments). Circulation 91: 2120.
38. Markus H.S., Barley J., Lunt R., Bland J.M., Jeffrey S., Carter N.D., and Brown M.M. 1995. Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma (see comments). Stroke 26: 1329.
39. 1 receptor-mediated pressor and chronotropic effects. J. Clin. Invest. 101: 527.
40. Matsusaka T., Nishimura H., Utsunomiya H., Kakuchi J., Niimura F., Inagami T., Fogo A., and Ichikawa I. 1996. Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J. Clin. Invest. 98: 1867.
41. Millan M.A., Carvallo P., Izumi S., Zemel S., Catt K.J., and Aguilera G. 1989. Novel sites of expression of functional angiotensin II receptors in the late gestation fetus. Science 244: 1340.
42. Missouris C.G., Barley J., Jeffery S., Carter N.D., Singer D.R., and MacGregor G.A. 1996. Genetic risk for renal artery stenosis: Association with deletion polymorphism in angiotensin I-converting enzyme gene. Kidney Int. 49: 534.
43. Niimura F., Labosky P.A., Kakuchi J., Okubo S., Yoshida H., Oikawa T., Ichiki T., Naftilan A.J., Fogo A., and Inagami T., et al. 1995. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J. Clin. Invest. 96: 2947.
44. Oliverio M.I., Best C.F., Kim H-S., Arendshorst W.J., Smithies O., and Coffman T.M. 1997. Angiotension II responses in AT1A receptor-deficient mice: A role for AT1B receptors in blood pressure regulation. Am. J. Physiol. 272: f515.
45. 1A receptors for angiotensin II. Am. J. Physiol. 274: F43.
46. Oliverio M.I., Kim H., Ito M., Le T., Audoly L., Best C.F., Hiller S., Kluckman K., Maeda N., Smithies O., and Coffman T.M. 1998b. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc. Natl. Acad. Sci. 95: 15496.
47. Pfeffer M.A., Lamas G.A., Vaughn D.E., Parisi A.F., and Braunwald E. 1988. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N. Engl. J. Med. 319: 80.
48. Piccini N., Knopf J.L., and Gross K.W. 1982. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Cell 30: 205.
49. Pryde P.G., Sedman A.B., Nugent C.E., and Barr M., Jr. 1993. Angiotensin-converting enzyme inhibitor fetopathy. J. Am. Soc. Nephrol. 3: 1575.
50. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., and Soubrier F. 1990. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86: 1343.
51. Sharp M.G., Fettes D., Brooker G., Clark A.F., Peters J., Fleming S., and Mullins J.J. 1996. Targeted inactivation of the Ren-2 gene in mice. Hypertension 28: 1126.
52. Singer D.R., Missouris C.G., and Jeffery S. 1996. Angiotensinconverting enzyme gene polymorphism. What to do about all the confusion (editorial) (see comments). Circulation 94: 236.
53. Smithies O. and Kim H.S. 1994. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc. Natl. Acad. Sci. 91: 3612.
54. SOLVD Investigators. 1991. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. The SOLVD Investigators. N. Engl. J. Med. 325: 303.
55. Sugaya T., Nishimatsu S., Tanimoto K., Takimoto E., Yamagishi T., Imamura K., Goto S., Imaizumi K., Hisada Y., and Otsuka A., et al. 1995. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J. Biol. Chem. 270: 18719.
56. Szombathy T., Szalai C., Katalin B., Palicz T., Romics L., and Csaszar A. 1998. Association of angiotensin II type 1 receptor polymorphism with resistant essential hypertension. Clin. Chim. Acta 269: 91.
57. Tian B., Meng Q.C., Chen Y.F., Krege J.H., Smithies O., and Oparil S. 1997. Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. Hypertension 30: 128.
58. Timmermans P., Chiu A., Herblin W., Wong P., and Smith R. 1992. Angiotensin II receptor subtypes. Am. J. Hypertens. 5: 406.
59. Timmermans P.B., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.A., and Smith R.D. 1993. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45: 205.
60. Tipnis S.R., Hooper N.M., Hyde R., Karran E., Christie G., and Turner A.J. 2000. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captoprilinsensitive carboxypeptidase. J. Biol. Chem. 275: 33238.
61. Tsuchida S., Matsusaka T., Chen X., Okubo S., Niimura F., Nishimura H., Fogo A., Utsunomiya H., Inagami T., and Ichikawa I. 1998. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J. Clin. Invest. 101: 755.
62. Turner A.J. and Hooper N.M. 2002. The angiotensin-converting enzyme gene family: Genomics and pharmacology. Trends Pharmacol. Sci. 23: 177.
63. Viberti G., Mogensen C.E., Groop L.C., and Pauls J.F. 1994. Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. J. Am. Med. Assoc. 271: 275.
64. Yababa M., Umemura S., Kihara M., Tamara K., Nyui N., Ishigami T., Ishii M., Kiuchi Y., Yagami K., Tanimoto K., Sugiyama F., Fukamizu A., and Murakami K. 1996. Altered development of vasculature in the kidney but not in the other main organs in angiotensinogen-deficient mice. Hypertension 28: 543A.
65. Yanai K., Saito T., Kakinuma Y., Kon Y., Hirota K., Taniguchi-Yanai K., Nishijo N., Shigematsu Y., Horiguchi H., Kasuya Y., Sugiyama F., Yagami K., Murakami K., and Fukamizu A. 2000. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J. Biol. Chem. 275: 5.
66. Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-de Jong R., Inagami T., and Ichikawa I. 1992. Analysis of the evolution of angiotensin II type I receptor gene in mammals (mouse, rat, bovine and human). Biochem. Biophys. Res. Commun. 186: 1042.
67. Yusuf S., Sleight P., Pogue J., Bosch J., Davies R., and Dagenais G. 2000. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 342: 145.
68. Zhang H., Wada J., Hida K., Tsuchiyama Y., Hiragushi K., Shikata K., Wang H., Lin S., Kanwar Y.S., and Makino H. 2001. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J. Biol. Chem. 276: 17132.