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Volumn 45, Issue 2-3, 2004, Pages 305-310

Intracellular metabolic compartmentation assessed by 13C magnetic resonance spectroscopy

Author keywords

GABA; Gln; Glu; glutamate; glutamine; glutamine synthetase; GS; Lac; lactate; magnetic resonance (spectroscopy); MR(S); PAG; PC; PDH; phosphate activated glutaminase; Pyr; pyruvate; pyruvate carboxylase; pyruvate dehydrogenase; TCA; aminobutyric acid

Indexed keywords

2 OXOGLUTARIC ACID; AMINO ACID; CARBON DIOXIDE; GLUTAMIC ACID; THIOPENTAL;

EID: 2442572392     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2003.10.010     Document Type: Article
Times cited : (38)

References (51)
  • 1
    • 0006786811 scopus 로고
    • Metabolic compartments in the brain: Their properties and relation to morphological structures
    • Balázs, R., Cremer, J.E. (Eds.), McMillan, London
    • Balázs, R., Patel, A.J., Richter, D., 1973. Metabolic compartments in the brain: their properties and relation to morphological structures. In: Balázs, R., Cremer, J.E. (Eds.), Metabolic Compartmentation in the Brain. McMillan, London, pp. 167-84.
    • (1973) Metabolic Compartmentation in the Brain , pp. 167-184
    • Balázs, R.1    Patel, A.J.2    Richter, D.3
  • 2
    • 0008732725 scopus 로고
    • Compartmentation of amino acid metabolism
    • Lajtha, A. (Ed.), Plenum Press, New York/London
    • Berl, S., Clarke, D.D., 1969. Compartmentation of amino acid metabolism. In: Lajtha, A. (Ed.), Handbook of Neurochemistry, vol. 2, first ed. Plenum Press, New York/London, pp. 447-472.
    • (1969) Handbook of Neurochemistry, Vol. 2, First Ed. , vol.2 , pp. 447-472
    • Berl, S.1    Clarke, D.D.2
  • 3
    • 84982337275 scopus 로고
    • Amino acid and protein metabolism of the brain - VI. Cerebral compartments of glutamic acid metabolism
    • Berl S., Lajtha A., Waelsch H. Amino acid and protein metabolism of the brain - VI. Cerebral compartments of glutamic acid metabolism. J. Neurochem. 7:1961;322-332
    • (1961) J. Neurochem. , vol.7 , pp. 322-332
    • Berl, S.1    Lajtha, A.2    Waelsch, H.3
  • 5
    • 0028966538 scopus 로고
    • Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
    • Cesar M., Hamprecht B. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase. J. Neurochem. 64:1995;2312-2318
    • (1995) J. Neurochem. , vol.64 , pp. 2312-2318
    • Cesar, M.1    Hamprecht, B.2
  • 7
    • 0032006244 scopus 로고    scopus 로고
    • Cellular distribution and kinetic properties of high-affinity glutamate transporters
    • Gegelashvili G., Schousboe A. Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res. Bull. 45:1997;233-238
    • (1997) Brain Res. Bull. , vol.45 , pp. 233-238
    • Gegelashvili, G.1    Schousboe, A.2
  • 8
    • 0032006244 scopus 로고    scopus 로고
    • Cellular distribution and kinetic properties of high-affinity glutamate transporters
    • Gegelashvili G., Schousboe A. Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res. Bull. 45:1998;233-238
    • (1998) Brain Res. Bull. , vol.45 , pp. 233-238
    • Gegelashvili, G.1    Schousboe, A.2
  • 9
    • 0002602845 scopus 로고
    • Primary culture of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. 1. Differentiated cells
    • Vernadakis, A. (Ed.), Martinus Nijhoff, Boston
    • Hertz, L., Schousboe, A., 1987. Primary culture of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. 1. Differentiated cells. In: Vernadakis, A. (Ed.), Model Systems of Development and Aging of the Nervous System, Martinus Nijhoff, Boston, pp. 19-31.
    • (1987) Model Systems of Development and Aging of the Nervous System , pp. 19-31
    • Hertz, L.1    Schousboe, A.2
  • 10
    • 0023907144 scopus 로고
    • Glutaminase in neurons and astrocytes cultured from mouse brain: Kinetic properties and effects of phosphate, glutamate, and ammonia
    • Hogstad S., Svenneby G., Torgner I.A., Kvamme E., Hertz L., Schousboe A. Glutaminase in neurons and astrocytes cultured from mouse brain: kinetic properties and effects of phosphate, glutamate, and ammonia. Neurochem. Res. 13:1988;383-388
    • (1988) Neurochem. Res. , vol.13 , pp. 383-388
    • Hogstad, S.1    Svenneby, G.2    Torgner, I.A.3    Kvamme, E.4    Hertz, L.5    Schousboe, A.6
  • 11
    • 0028334285 scopus 로고
    • Heterogeneity of monoamine oxidase activities in synaptic and non-synaptic mitochondria derived from three brain regions: Some functional implications
    • Lai J.C., Leung T.K., Lim L. Heterogeneity of monoamine oxidase activities in synaptic and non-synaptic mitochondria derived from three brain regions: some functional implications. Metab. Brain Dis. 9:1994;53-66
    • (1994) Metab. Brain Dis. , vol.9 , pp. 53-66
    • Lai, J.C.1    Leung, T.K.2    Lim, L.3
  • 12
    • 0021324639 scopus 로고
    • The activities of some energy-metabolising enzymes in nonsynaptic (free) and synaptic mitochondria derived from selected brain regions
    • Leong S.F., Lai J.C., Lim L., Clark J.B. The activities of some energy-metabolising enzymes in nonsynaptic (free) and synaptic mitochondria derived from selected brain regions. J. Neurochem. 42:1984;1306-1312
    • (1984) J. Neurochem. , vol.42 , pp. 1306-1312
    • Leong, S.F.1    Lai, J.C.2    Lim, L.3    Clark, J.B.4
  • 14
    • 0141485079 scopus 로고
    • Amino acid and protein metabolism of the brain - IV. the metabolism of glutamic acid
    • Lajtha A., Berl S., Waelsch H. Amino acid and protein metabolism of the brain - IV. The metabolism of glutamic acid. J. Neurochem. 3:1959;322-332
    • (1959) J. Neurochem. , vol.3 , pp. 322-332
    • Lajtha, A.1    Berl, S.2    Waelsch, H.3
  • 15
  • 16
    • 0033982623 scopus 로고    scopus 로고
    • Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells
    • McKenna M.C., Stevenson J.H., Huang X., Tildon J.T., Zielke C.L., Hopkins I.B. Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells. Neurochem. Int. 36:2000;451-459
    • (2000) Neurochem. Int. , vol.36 , pp. 451-459
    • McKenna, M.C.1    Stevenson, J.H.2    Huang, X.3    Tildon, J.T.4    Zielke, C.L.5    Hopkins, I.B.6
  • 17
    • 0030061356 scopus 로고    scopus 로고
    • Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
    • McKenna M.C., Sonnewald U., Huang X., Stevenson J., Zielke H.R. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J. Neurochem. 66:1996;386-393
    • (1996) J. Neurochem. , vol.66 , pp. 386-393
    • McKenna, M.C.1    Sonnewald, U.2    Huang, X.3    Stevenson, J.4    Zielke, H.R.5
  • 19
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • Norenberg M.D., Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161:1979;303-310
    • (1979) Brain Res. , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 20
    • 0016137008 scopus 로고
    • 2-fixing enzymes in the metabolism of rat brain
    • 2-fixing enzymes in the metabolism of rat brain. J. Neurochem. 22:1974;717-724
    • (1974) J. Neurochem. , vol.22 , pp. 717-724
    • Patel, M.S.1
  • 22
    • 0345493814 scopus 로고    scopus 로고
    • Recent structural insight into mitochondria gained by microscopy
    • Perkins G.A., Frey T.G. Recent structural insight into mitochondria gained by microscopy. Micron. 31:2000;97-111
    • (2000) Micron , vol.31 , pp. 97-111
    • Perkins, G.A.1    Frey, T.G.2
  • 25
    • 0035947220 scopus 로고    scopus 로고
    • The effect of thiopental on glutamate metabolism in cerebellar astrocytes
    • Qu H., van der Gaag M., Le Maire T., Sonnewald U. The effect of thiopental on glutamate metabolism in cerebellar astrocytes. Neurosci. Lett. 304:2001;141-144
    • (2001) Neurosci. Lett. , vol.304 , pp. 141-144
    • Qu, H.1    Van Der Gaag, M.2    Le Maire, T.3    Sonnewald, U.4
  • 26
    • 0018094446 scopus 로고
    • Glutamine precursor for the GABA and glutamate transmitter pools
    • Reubi C.J., Van den Berg C.J., Cuénod M. Glutamine precursor for the GABA and glutamate transmitter pools. Neurosci. Lett. 10:1978;171-174
    • (1978) Neurosci. Lett. , vol.10 , pp. 171-174
    • Reubi, C.J.1    Van Den Berg, C.J.2    Cuénod, M.3
  • 27
    • 0018386655 scopus 로고
    • Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes
    • Schousboe A., Hertz L., Svenneby G., Kvamme E. Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes. J. Neurochem. 32:1979;943-950
    • (1979) J. Neurochem. , vol.32 , pp. 943-950
    • Schousboe, A.1    Hertz, L.2    Svenneby, G.3    Kvamme, E.4
  • 29
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocytic-specific enzyme implicated in the replenishment of amino acids neurotransmitter pools
    • Shank R.P., Bennett G.S., Freytag S.O., Campbell G.L. Pyruvate carboxylase: an astrocytic-specific enzyme implicated in the replenishment of amino acids neurotransmitter pools. Brain Res. 329:1985;364-367
    • (1985) Brain Res. , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Freytag, S.O.3    Campbell, G.L.4
  • 32
    • 0027338137 scopus 로고
    • 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle
    • 13C NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle J. Neurochem. 61:1993;1179-1182
    • (1993) J. Neurochem. , vol.61 , pp. 1179-1182
    • Sonnewald, U.1    Westergaard, N.2    Petersen, S.B.3    Unsgård, G.4    Schousboe, A.5
  • 35
    • 0031940131 scopus 로고    scopus 로고
    • Mitochondrial heterogeneity in the brain at the cellular level
    • Sonnewald U., Hertz L., Schousboe A. Mitochondrial heterogeneity in the brain at the cellular level. J. Cereb. Blood Flow Metab. 18:1998;231-237
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 231-237
    • Sonnewald, U.1    Hertz, L.2    Schousboe, A.3
  • 36
    • 0030952190 scopus 로고    scopus 로고
    • Glutamine transport in cerebellar granule cells in culture
    • Su T.Z., Campbell G.W., Oxender D.L. Glutamine transport in cerebellar granule cells in culture. Brain Res. 757(1):1997;69-78
    • (1997) Brain Res. , vol.757 , Issue.1 , pp. 69-78
    • Su, T.Z.1    Campbell, G.W.2    Oxender, D.L.3
  • 38
    • 0015071185 scopus 로고
    • A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
    • Van den Berg C.J., Garfinkel D. A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem. J. 123:1971;211-218
    • (1971) Biochem. J. , vol.123 , pp. 211-218
    • Van Den Berg, C.J.1    Garfinkel, D.2
  • 39
    • 0034635496 scopus 로고    scopus 로고
    • Cloning and functional identification of a neuronal glutamine transporter
    • Varoqui H., Zhu H., Yao D., Ming H., Erickson J.D. Cloning and functional identification of a neuronal glutamine transporter. J. Biol. Chem. 275:2000;4049-4054
    • (2000) J. Biol. Chem. , vol.275 , pp. 4049-4054
    • Varoqui, H.1    Zhu, H.2    Yao, D.3    Ming, H.4    Erickson, J.D.5
  • 41
    • 0035577327 scopus 로고    scopus 로고
    • Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes
    • Waagepetersen H.S., Hong Q., Schousboe A., Sonnewald U. Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes. J. Neurosci. Res. 66:2001;763-770
    • (2001) J. Neurosci. Res. , vol.66 , pp. 763-770
    • Waagepetersen, H.S.1    Hong, Q.2    Schousboe, A.3    Sonnewald, U.4
  • 42
    • 0034846461 scopus 로고    scopus 로고
    • Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes
    • Waagepetersen H.S., Sonnewald U., Larsson O.M., Schousboe A. Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes. Glia. 35:2001;246-252
    • (2001) Glia , vol.35 , pp. 246-252
    • Waagepetersen, H.S.1    Sonnewald, U.2    Larsson, O.M.3    Schousboe, A.4
  • 44
    • 0141676472 scopus 로고    scopus 로고
    • Compartmentation of glutamine, glutamate and GABA metabolism in neurons and astrocytes: Functional implications
    • Waagepetersen, H.S., Sonnewald, U., Schousboe, A., 2003b. Compartmentation of glutamine, glutamate and GABA metabolism in neurons and astrocytes: functional implications. Neuroscientist 9 (5), 398-403.
    • (2003) Neuroscientist , vol.9 , Issue.5 , pp. 398-403
    • Waagepetersen, H.S.1    Sonnewald, U.2    Schousboe, A.3
  • 45
    • 0022478666 scopus 로고
    • Exogenous glutamate is metabolized to glutamine and exported by rat primary astrocyte cultures
    • Waniewski R.A., Martin D.L. Exogenous glutamate is metabolized to glutamine and exported by rat primary astrocyte cultures. J. Neurochem. 47:1986;304-313
    • (1986) J. Neurochem. , vol.47 , pp. 304-313
    • Waniewski, R.A.1    Martin, D.L.2
  • 48
    • 0021037707 scopus 로고
    • Pyruvate carboxylase activity in primary cultures of astrocytes and neurons
    • Yu A.C.H., Drejer J., Hertz L., Schousboe A. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J. Neurochem. 41:1983;1484-1487
    • (1983) J. Neurochem. , vol.41 , pp. 1484-1487
    • Yu, A.C.H.1    Drejer, J.2    Hertz, L.3    Schousboe, A.4
  • 49
    • 0023820776 scopus 로고
    • 15N]glutamine: Implications for the glutamine-glutamate cycle
    • 15N ]glutamine: implications for the glutamine-glutamate cycle J. Neurochem. 51:1988;843-850
    • (1988) J. Neurochem. , vol.51 , pp. 843-850
    • Yudkoff, M.1    Nissim, I.2    Pleasure, D.3
  • 51
    • 0034744108 scopus 로고    scopus 로고
    • 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes
    • 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes Glia. 34:2001;200-212
    • (2001) Glia , vol.34 , pp. 200-212
    • Zwingmann, C.1    Richter-Landsberg, C.2    Leibfritz, D.3


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